Primary primitive neuroectodermal tumors of the retina and ciliary body in dogs

Regan, Daniel P.; Dubielzig, Richard R.; Zeiss, Caroline J.; Charles, Brad; Hoy, Sarah S.; Ehrhart, E. J.

doi:10.1111/vop.12056

Cited by 21 publications

(27 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a surprising paradoxic discrepancy between the evolutionary conserved RB-E2F pathway in most eukaryotes lineage species, including animals and plants (Cao et al, 2010) and the fact that RB1 loss of function causes preferential retinal oncogenesis as a humanspecific condition, with no proven equivalent in the animal kingdom other than anecdotal cases of sporadic unilateral retinoblastoma-like tumors (RB1 status not investigated) in the dog and lama (Syed et al, 1997;Fugaro et al, 2005;Regan et al, 2013). This has imposed alternative models based in xenografts or genetically engineered mouse models (GEMMs) to conduct translational research in the field.…”

Section: Animal Modelsmentioning

confidence: 99%

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Munier

Beck‐Popovic

Chantada

et al. 2019

Progress in Retinal and Eye Research

164

157

View full text Add to dashboard Cite

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to preserve life, with ocular survival, visual preservation and quality of life as secondary aims. Historically, enucleation was the first successful therapeutic approach to decrease mortality, followed over 100 years ago by the first eye salvage attempts with radiotherapy. This led to the empiric delineation of a window for conservative management subject to a "state of metastatic grace" never to be violated. Over the last two decades, conservative management of retinoblastoma witnessed an impressive acceleration of improvements, culminating in two major paradigm shifts in therapeutic strategy. Firstly, the introduction of systemic chemotherapy and focal treatments in the late 1990s enabled radiotherapy to be progressively abandoned. Around 10 years later, the advent of chemotherapy in situ, with the capitalization of new routes of targeted drug delivery, namely intra-arterial, intravitreal and now intracameral injections, allowed significant increase in eye preservation rate, definitive eradication of radiotherapy and reduction of systemic chemotherapy. Here we intend to review the relevant knowledge susceptible to improve the conservative management of retinoblastoma in compliance with the "state of metastatic grace", with particular attention to (i) reviewing how new imaging modalities impact the frontiers of conservative management, (ii) dissecting retinoblastoma genesis, growth patterns, and intraocular routes of tumor propagation, (iii) assessing major therapeutic changes and trends, (iv) proposing a classification of relapsing retinoblastoma, (v) examining treatable/preventable disease-related or treatment-induced complications, and (vi) appraising new therapeutic targets and concepts, as well as liquid biopsy potentiality.

show abstract

Section: Animal Modelsmentioning

confidence: 99%

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Munier

Beck‐Popovic

Chantada

et al. 2019

Progress in Retinal and Eye Research

164

157

View full text Add to dashboard Cite

show abstract

“… 8 In dogs, intraocular retinoblastoma‐like tumors are more likely to occur in young patients, while intraocular medulloepithelioma has been reported in older animals. 4 Determination of a specific cell line of the tumor in this 10‐year‐old dog was not possible due to the extremely primitive stage of development of the tumor cells. Data for dogs with ETMRs in dogs regarding breed or sex predilection, clinical characteristics, treatment options and outcomes, and prognosis are not available due to the rarity of this neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Retrobulbar embryonal tumor with multilayered rosettes in a golden retriever dog

Martins

Struthers

Abbott

et al. 2020

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…). IHC staining protocol was similar to that described in Regan et al . The neoplastic cells exhibited positive cytoplasmic staining for NSE.…”

Section: Additional Testingmentioning

confidence: 97%

Clinical behavior of intraocular teratoid medulloepithelioma in two‐related Quarter Horses

Monk

Craft

Abbott

et al. 2016

Veterinary Ophthalmology

View full text Add to dashboard Cite

The objective of this paper is to describe clinical behavior, histopathologic features, and immunohistochemical staining of two-related horses with intraocular teratoid medulloepithelioma. Two-related Quarter Horses with similar intraocular masses presented to the UF-CVM Comparative Ophthalmology Service for evaluation and treatment. The first horse, a 3-year-old gelding, had glaucoma and a cyst-like mass in the anterior chamber. Enucleation was performed. Histopathology revealed a teratoid medulloepithelioma. The tumor was considered to be completely excised. Fifteen months later, the gelding presented with swelling of the enucleated orbit and local lymph nodes with deformation of the skull. Cytology revealed neuroectodermal neoplastic cells. Necropsy confirmed tumor metastasis. Six weeks later, a 9-year-old mare, a full sibling to the gelding, presented for examination. An infiltrative mass of the iris and ciliary body was found that extended into the anterior, posterior, and vitreal chambers. Uveitis was present, but secondary glaucoma was not noted. Enucleation was performed and the histopathologic diagnosis was also teratoid medulloepithelioma. The mare has had no recurrence to date, 2 years following enucleation. Metastasis of intraocular teratoid medulloepithelioma is possible. Staging is recommended in cases where the diagnosis of teratoid medulloepithelioma is confirmed. Surveillance of full siblings is recommended until more information regarding etiology is known.

show abstract

Primary primitive neuroectodermal tumors of the retina and ciliary body in dogs

Cited by 21 publications

References 32 publications

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Conservative management of retinoblastoma: Challenging orthodoxy without compromising the state of metastatic grace. “Alive, with good vision and no comorbidity”

Retrobulbar embryonal tumor with multilayered rosettes in a golden retriever dog

Clinical behavior of intraocular teratoid medulloepithelioma in two‐related Quarter Horses

Contact Info

Product

Resources

About