Primary pulmonary Hodgkin Lymphoma simulating a mediastinal tumour: an uncommon occurrence.

Fratoni, Stefano; Niscola, Pasquale; Abruzzese, Elisabetta; Trawinska, Malgorzata Monika; Mercadante, Edoardo; Casullo, A.; Fabritiis, Paolo de; Perrotti, Alessio; Santeusanio, Giuseppe

doi:10.4084/mjhid.2013.013

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Our experience demonstrates that suspicious lesions should undergo open lung biopsy or surgical resection for ultimate diagnosis as supported in literature as well. 7 , 12-14 …”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Hodgkin Lymphoma

et al. 2015

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“…Our experience demonstrates that suspicious lesions should undergo open lung biopsy or surgical resection for ultimate diagnosis as supported in literature as well. 7 , 12-14 …”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Hodgkin Lymphoma

et al. 2015

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Primary pulmonary Hodgkin's lymphoma and a review of the literature since 2006

Cooksley¹,

Judge

Brown

2014

BMJ Case Reports

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A 28-year-old woman of Laotian origin presented with dry cough, fevers, night sweats and weight loss over the preceding 6 weeks. Radiological investigations revealed large complex cavitary lesions in the middle and lower lobes of the right lung, with no mediastinal lymph node enlargement. Bronchoscopic investigations did not yield a diagnosis. CT-guided fine-needle aspiration raised the possibility of Langerhans cell histiocytosis. Open lung biopsy initially supported this, but eventually a microscopic and immunohistochemical diagnosis of Hodgkin's lymphoma was made. The final diagnosis was primary pulmonary Hodgkin's lymphoma. We present a new case as well as a literature review of reported cases published since 2006.

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Clinicopathological Characteristics of Primary Pulmonary Hodgkin Lymphoma (PPHL): Two Institutional Experiences with Comprehensive Literature Review of 115 PPHL Cases

Jung

Kim

Han

et al. 2022

JCM

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Primary pulmonary Hodgkin lymphoma (PPHL) is an extremely rare condition. Its clinicopathological characteristics remain unclear because of the limited number of patients with PPHL. The aim of this study was to comprehensively analyze the clinicopathological characteristics of PPHL. We reviewed the electronic medical records and pathology slides of our 10 PPHL patients. The female-to-male ratio was 6:4, and the mean age was 41 years. Although three patients had no symptoms, seven had localized or generalized symptoms, including cough, sputum, chest discomfort/pain, and weight loss. Some cases had not been diagnosed as PPHL in the initial needle biopsy. Four patients underwent surgical resection. With chemotherapy, eight patients achieved complete remission. We also conducted a thorough literature review on 105 previously reported PPHL cases. Among a total of 115 PPHL cases, the most common subtype was nodular sclerosis (37.4%). More than half of the cases (55%) were clinically suspected as infectious pneumonia. Of 61 patients whose biopsies were available, 27 (44.3%) were diagnosed correctly as Hodgkin lymphoma, whereas the misdiagnoses included tuberculosis, Langerhans cell histiocytosis, solitary fibrous tumor, and adenocarcinoma. We demonstrated that PPHL represents a diagnostic challenge on small biopsies. Recognizing that this rare tumor can mimic infectious and inflammatory diseases as well as malignancies is important because the accurate diagnosis of PPHL is essential for adequate clinical management.

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Primary pulmonary Hodgkin Lymphoma simulating a mediastinal tumour: an uncommon occurrence.

Abstract: The case of a patient with primary pulmonary Hodgkin Lymphoma simulating a mediastinal tumour is reported for its rarity and the diagnostic concerns encountered by us.

Cited by 3 publications

References 7 publications

Primary Pulmonary Hodgkin Lymphoma

Primary Pulmonary Hodgkin Lymphoma

Primary pulmonary Hodgkin's lymphoma and a review of the literature since 2006

Clinicopathological Characteristics of Primary Pulmonary Hodgkin Lymphoma (PPHL): Two Institutional Experiences with Comprehensive Literature Review of 115 PPHL Cases

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