Primary squamous cell carcinoma PSCC of the breast is extremely rare [1]. The histogenesis of this tumour is debatable but compelling evidences have been traced to the skin epidermis, the nipple or epithelium of a skin adnexae and deep-seated dermoid cyst or squamous metaplasia of the ductal epithelial cells following chronic inflammation [2].Introduction: Pure squamous cell carcinoma of the breast is very rare. Strict histological criteria must be followed before the diagnosis can be made. Squamous cell carcinoma of the skin and/or its appendages in which the squamous cell carcinoma is a portion should be excluded. Areas of metaplastic change in an otherwise ductal carcinoma should not be diagnosed as pure squamous cell carcinoma. Squamous cell carcinoma from other parts of the body with metastasis to the breast should also be excluded.
Case presentation:We report a case of primary squamous cell carcinoma of the breast in a 60-year-old woman.Discussion: It is a breast carcinoma entirely composed of squamous cells that may be keratinized, non-keratinized or spindled. The pure squamous cell carcinoma usually presents with central cystic cavity, which we also found in our case. The squamous cells seen in this case was supported by immunohistochemical evidence.
Conclusion:Although a rare breast cancer subtype, pure squamous cell carcinoma of the breast is of considerable interest due to its pathological heterogeneity and differences in clinical behavior.