Primary pure squamous cell carcinoma of breast in a young female -a rare occurrence Primary squamous cell carcinoma of breast is a rare disease. Incidence for primary SCC breast is 0.04-0.1 % of all malignancies of breast. A pure form of primary SCC breast is also described and its incidence is still less. Biologically it behaves differently and usually doesn't metastasize to lymph nodes, though distant metastasis is more common. They occur usually in elderly women. Mean age of presentation is 54 years.We report the youngest patient so far -a 27 years old woman diagnosed initially as having fibrocystic disease and later as primary pure SCC breast. She did not have any other focus of malignancy in the body and is doing well 3-1/2 years post surgery and radiotherapy.

Intracranial schwannomas most commonly occur in relation to vestibular nerves followed by trigeminal nerves. Authors describe a very unusual case of schwannomas originating in lateral recess of the fourth ventricle. Tumor was completely excised micro-surgically via midline suboccipital craniectomy and C1 laminectomy. Dissection of the surgical specimen revealed that the tumor was completely free from surrounding structures and just hanging in the fourth ventricle. It was not attached to any cranial nerves, brain parenchyma, and blood vessel or to the dura mater. Histopathological examination confirmed the diagnosis of schwannoma. To our knowledge, no such case has been reported so far from this extremely rare location. Relevant literature is reviewed and hypothesis for ectopic location of these tumors has been highlighted.

Leiomyoma of the mesentery is an uncommon tumor among gastrointestinal stromal tumors. This has been documented in adults and children. However, there is only one case reported in an infant and we are presenting such a rare second case in a 6-month-old male infant. Exploration of the abdomen revealed a solid mass within the leaves of the mid-ileal mesentery that could be enucleated out entirely after careful dissection. Histopathology suggested it to be leiomyoma of mesentery.

Coexistence of squamous cell carcinoma cervix with tuberculosis cervix, as reported in literature, is a rare entity. Only 8 cases have been reported in the world literature so far. Tuberculosis in general is rampant in developing countries, especially in India, and so is carcinoma cervix and hence one would expect a much higher incidence of coexistence of two. However tuberculosis cervix is a rarely reported disease.We report a case of tuberculosis cervix associated with squamous cell carcinomaand regional lymph node involvement in a postmenopausal woman.Journal of Pathology of Nepal (2015) Vol. 5, 781-783

Background: Adrenal cortical carcinoma is a rare malignant tumor. Several systems were proposed for diagnosis and evaluation of adrenocortical tumors.Weiss system is most commonly used method for assessment of malignancy, but only few studies has applied this criteria, for assesement of prognosis. The aim of this study was to analyzethe histological features & immunostaining status of adrenocortical carcinoma diagnosed according to Weiss criteria and correlate the data with patient clinical finding and outcomes. Materials and Methods: In this study clinicopathological features of 12 cases were reviewed and diagnosed as adrenocortical carcinoma on the basis of Weiss criteria and immunostaining. Grading was done according to the nine histopathological criteria of Weiss and is applied for assessment of prognosis. Each tumor was labeled malignant, when it scored ≥4 point of this histological criteria, tumors with ≤3 points were considered as adenoma and not included in the series. Immunostains applied were, Vimentin, Cytokeratin, synaptophysin, chromogranin, Vinyl mandilic acid, epithelial membrane antigen and Melan A. Results: All cases studied, presented at least four of the Weiss criteria and thus diagnosed as adrenocortical carcinoma. Patients with 7 and more score of Weiss criteria is considered as high grade carcinoma. Immunostains, have role in the diagnosis of adrenal cortical tumor, but does not have any significant clinical outcome.Conclusion: Weiss criteria was found to be a good prognostic factor in adrenal cortical carcinoma. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6020 JPN 2012; 2(3): 193-197