Primary rectal lymphoma: an unusual treatment for a rare case

Ünal, Bülent; Karabeyoğlu, Melih; Erel, Serap; Bozkurt, Betül; Koçer, Bülent; Cengîz, Ömer

doi:10.1136/pgmj.2007.064006

Cited by 10 publications

(9 citation statements)

References 14 publications

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“…While treatment strategies in nodal NHL are well established, those for GI NHL, particularly PRL, remain debatable and controversial. Because of the uncommon nature of this cancer, very few studies have investigated prognostic factors that will allow clinicians to determine outcome and risk for relapse [678]. …”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics, treatment, and outcome of primary rectal lymphoma: a single center experience of 16 patients

Jeong

Kim

et al. 2017

Blood Res

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BackgroundThe rectum is a relatively uncommon site for lymphoma compared with other gastrointestinal sites; no consensus regarding management of primary rectal lymphoma (PRL) has been formed due to its limited frequency. We aimed to investigate clinical characteristics and treatment outcomes in patients with PRL in a single center patient cohort.MethodsWe retrospectively analyzed the results of 16 consecutive patients with PRL, identified and treated at the Asan Medical Center, Seoul, Korea between January 1993 and December 2014.ResultsThese 16 patients with PRL constituted 0.8% of all non-Hodgkin's lymphoma patients (N=1,984). B-cell lymphomas (N=14) made up the majority of the series, and half of these were extranodal marginal zone lymphomas (ENMZL, N=7). Ten patients received systemic chemotherapy with (N=3) or without rituximab (N=7), and 4 of these received additional local therapy. The others received radiotherapy (N=3) or endoscopic mucosal resection (N=3). Twelve patients (75%) achieved complete response (CR) after first-line treatment. Event-free survival (EFS) and overall survival (OS) in stages IE and IIE were significantly longer compared with stages IVE (P=0.001 and P=0.001, respectively). All patients with ENMZL (N=7) achieved CR during or after initial treatment.ConclusionPRL is very rare and seems to present mostly as B-cell type. Stage is the most important prognostic factor, with significantly better survival associated with localized diseases. ENMZL may be one of the most common types of PRL with favorable treatment outcomes.

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Section: Introductionmentioning

confidence: 99%

Clinical characteristics, treatment, and outcome of primary rectal lymphoma: a single center experience of 16 patients

Jeong

Kim

et al. 2017

Blood Res

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“…CD2, CD3, CD4, CD7, and CD8 are used to determine T cell lymphoma. CD20, CD79a, and CD10 are used to determine B cell lymphoma [16]. The most common histological types of primary colorectal lymphomas, following the Revised European-American Classification of Lymphoid Neoplasms/World Health Organization classification of lymphoid neoplasms (REAL/WHO), are: diffuse large B cell lymphoma, Mantle cell lymphoma, and Burkitt's lymphoma [17].…”

Section: Discussionmentioning

confidence: 99%

Primary Rectal Non-Hodgkin’s Lymphoma Treated with Urgent Radiotherapy and Chemotherapy: A Case Report and Literature Review

Rahman¹,

Chowdhury²,

Begum³

et al. 2020

Gastrointest Tumors

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Rectal malignancy is usually symptomatic due to its location, and most of the time presents with pain and bleeding due to its growth and ulceration. It is difficult to identify the primary as carcinoma or lymphoma based on symptoms only, as both have a similar presentation. As it presents the rarest form of histology, non-Hodgkin’s lymphoma in the rectum is still difficult to diagnose initially, and its treatment is debatable. We describe the case of a 49-year-old male from Bangladesh with the same presentation. His treatment was delayed for more than a month as immunohistochemistry and staging delayed the final diagnosis. The disease was diagnosed as stage IE with the help of a positron emission tomography (PET)-CT scan, and due to the local progression the patient had a massive rectal bleeding that needed an urgent intervention. Radiotherapy was applied to stop the bleeding. Hypofraction followed by a conventional fraction of external beam radiotherapy (EBRT) with a total of 40 Gy was applied. Post-EBRT digital rectal examination showed no residual except scaring, and a PET scan was also negative for residual disease. Due to uncertainties and lack of any precious guideline, 6 cycles of adjuvant chemotherapy with the R-CHOP schedule were also completed. Without surgery, the combination of EBRT and chemotherapy helped to preserve the organ, and the patient has been disease free for more than 2.5 years since his treatment.

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“…The CD2, CD3, CD4, CD7 and CD8 are used to determine the T cell lymphoma. The CD20, CD79a, and CD10 are used to determine the B cell lymphoma [5]. The most common histological types of primary colorectal lymphomas, following the Revised European-American Classification of Lymphoid Neoplasms/World Health Organisation classification of lymphoid neoplasms (REAL/WHO), are: diffuse large B-cell lymphoma, Mantle-cell lymphoma and Burkitt's lymphoma [1].…”

Section: Discussionmentioning

confidence: 99%

Role of chemotherapy in the management of primary rectal lymphoma: a case report and review of the literature

et al. 2009

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IntroductionPrimary rectal lymphoma is a rare disease. In this paper we present an unusual case of primary rectal lymphoma which was managed with chemotherapy and discussed by a thorough review of the related literature.Cases presentationAn 85-years-male patient was diagnosed in Sidi Mohammed Ben Abdellah Hospital as having diffuse large B-cell lymphoma of the rectum at a bulky stage two. This patient was managed successfully with 8 treatment cycles of Cyclophosphamide 750 mg/m2 at day 1 of each cycle, Doxorubicin (50 mg/m2 in the first 4 cycles and 25 mg/m2 in the subsequent cycles) at day 1 of each cycle, Vincristine 1.4 mg/m2 at day 1 of each cycle, and prednisone 50 mg/m2 at day 1 to 5 of each cycle.ConclusionThe optimal treatment of primary rectal lymphoma needs more research studying to be achieved.

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Primary rectal lymphoma: an unusual treatment for a rare case

Cited by 10 publications

References 14 publications

Clinical characteristics, treatment, and outcome of primary rectal lymphoma: a single center experience of 16 patients

Clinical characteristics, treatment, and outcome of primary rectal lymphoma: a single center experience of 16 patients

Primary Rectal Non-Hodgkin’s Lymphoma Treated with Urgent Radiotherapy and Chemotherapy: A Case Report and Literature Review

Role of chemotherapy in the management of primary rectal lymphoma: a case report and review of the literature

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