Role of chemotherapy in the management of primary rectal lymphoma: a case report and review of the literature

Abstract

IntroductionPrimary rectal lymphoma is a rare disease. In this paper we present an unusual case of primary rectal lymphoma which was managed with chemotherapy and discussed by a thorough review of the related literature.Cases presentationAn 85-years-male patient was diagnosed in Sidi Mohammed Ben Abdellah Hospital as having diffuse large B-cell lymphoma of the rectum at a bulky stage two. This patient was managed successfully with 8 treatment cycles of Cyclophosphamide 750 mg/m2 at day 1 of each cycle, Doxorubicin (50 mg/m2 in the first 4 cycles and 25 mg/m2 in the subsequent cycles) at day 1 of each cycle, Vincristine 1.4 mg/m2 at day 1 of each cycle, and prednisone 50 mg/m2 at day 1 to 5 of each cycle.ConclusionThe optimal treatment of primary rectal lymphoma needs more research studying to be achieved.

Surgical resection combined with chemotherapy can help achieve better outcomes in patients with primary colonic lymphoma

“…The optimal treatment protocol for PCL is contentious [24,25]. Some authors have suggested systemic chemotherapy alone as the standard treatment, with surgery reserved for complications such as perforation, obstruction, and bleeding [8], whereas others believe that surgery provides better local disease control and improves survival outcome [14,26,27].…”

Primary Rectal Non-Hodgkin’s Lymphoma Treated with Urgent Radiotherapy and Chemotherapy: A Case Report and Literature Review

“…In our case, colonoscopy showed slough in the rectum, and colonoscopy biopsy revealed a possibly lymphoproliferative lesion (NHL). B cell lymphoma constitutes 85% of all primary colorectal lymphomas, with T cell lymphoma accounting for the remainder (15%) [15]. The differentiation between both lymphomas is done by the use of a cluster of differentiation antibodies (CD).…”

Rectal Mucinous Adenocarcinoma Invading Retrorectal Dermoid Cysts: A Case Report

“…For tumors not sensitive to chemoradiotherapy, surgery is the first choice. For rectal lymphomas, chemotherapy without surgery can be considered (6)(7)(8)(9)(10)(11).…”