Primary renal carcinoid tumour with lung metastasis misdiagnosed as renal cell carcinoma

Daboul, Nour; Monga, Dulabh; Bunker, Mark

doi:10.1136/bcr-2015-213432

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…In our study, seven cases (24.1%, 7/29) had local renal sinus, 16 , 20 , 21 perirenal fat and nerve invasion; eight cases (27.6%, 8/29) had lymph nodes metastasis; 6 , 16 , 17 , 21 , 27 and nine cases (31%, 9/29) had distant metastasis, 6 , 7 , 13 , 14 , 16 , 21 , 22 , 25 , 26 including five (17.2%, 5/29) cases of liver metastasis 6 , 7 , 14 , 16 , 26 and three cases (10.3%, 3/29) of lung metastasis. 6 , 21 , 25 In addition, the tumor can metastasize to bone, 6 contralateral kidney and adrenal, 13 eye, 14 pancreas, 21 , 25 thyroid, skin, 13 renal vein and inferior vena cava. 22 Among the cases of distant metastasis, 20.7% of patients with metastasis of renal carcinoid are at initial diagnosis.…”

Section: Discussionsupporting

confidence: 46%

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Hua¹,

Zhang²

2022

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Primary carcinoid tumor of the kidney is an extremely rare well-differentiated neuroendocrine tumor, which is generally a low-grade malignant cancer with a good prognosis. Carcinoid tumors are rarely found in the urinary system. Here, we report a 34-year-old woman with primary renal well-differentiated neuroendocrine tumor who underwent nephron sparing surgery and no evidence of recurrence or distant metastasis was found during routine follow-up. We searched the case of renal carcinoid with the search phrase “carcinoid [title] and kidney [title]” and “carcinoid [title] and renal [title]” using the PubMed and restricted the search to articles published in English since 2013. The clinical manifestations, age, sex, tumor size, location, gross pathology, light microscopy and immunohistochemistry were analyzed. A total of 28 cases of renal carcinoid were retrieved from PubMed. Higher proportion of positive labeling of CgA, Syn, NSE and CD56 are most valuable in the diagnosis of primary renal well-differentiated neuroendocrine tumor. At present, radical nephrectomy remains the gold standard in the curative-intent therapy for well-differentiated neuroendocrine carcinoma of kidney, in metastatic renal carcinoid, long-term use of octreotide may be an effective adjuvant therapy.

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Section: Discussionsupporting

confidence: 46%

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Hua¹,

Zhang²

2022

OTT

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“…RCT associated with horseshoe kidneys, usually occur in men. [ 4 , 7 , 9 ] All our three cases showed occurrence in the right kidney, but none of them had such lesions such as horseshoe kidney, teratoma or polycystic kidney.…”

Section: Discussionmentioning

confidence: 75%

“…[ 3 ] In addition, some of the symptoms of RCT include abdominal or lumbago, hematuria, constipation, frequent urination, fever and a loss of weight. [ 2 , 4 ] The vasoactive substances (serotonin) produced by tumors cause clinical manifestations of carcinoid syndrome such as blushing or diarrhea. [ 5 , 6 ] About 13% RCT patients show carcinoid syndrome, [ 5 ] but none of our cases showed this clinical manifestation.…”

Section: Discussionmentioning

confidence: 99%

“…[ 5 , 6 ] About 13% RCT patients show carcinoid syndrome, [ 5 ] but none of our cases showed this clinical manifestation. The pathogenesis of primary RCT are not clear, there are many hypotheses about the tumors [ 4 , 7 , 8 ] :…”

Section: Discussionmentioning

confidence: 99%

“…There are just almost 100 cases of carcinoid tumors in kidney since the first case was reported in 1966. [ 2 – 4 ] Most of the primary renal carcinoid tumors (RCT)are misdiagnosed due to lack of the specific clinical manifestations. Therefore, radiological evaluation of primary RCT can be challenging.…”

Section: Introductionmentioning

confidence: 99%

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Primary renal carcinoid tumors

Chen

Shu

et al. 2021

Medicine

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Rationale: Primary renal carcinoid tumors are very rare and only about 100 cases have been reported in the medical literature. There are even fewer articles on the imaging manifestations of primary renal carcinoid tumors. Patient concerns: We present 3 cases of patients with lumbago and hematuria. These were cases of primary renal carcinoid tumors with initial suspicion of suprarenal epithelioma. Diagnoses: Renal lesions were detected on abdomen computed tomography (CT) imaging. The 3 cases presented as solid/cystic solid renal mass with uniform or non-uniform density, calcification in the mass, and enhanced heterogeneity. Interventions: The laparoscopic partial/radical nephrectomy were performed. Outcomes: The postoperative histological diagnosis were primary renal carcinoid tumors. Case 2 been lost to follow-up in 3 patients, and the other 2 patients (Case 1 and 3) are still alive. Case 1 had intrahepatic metastases. Lessons: Primary renal carcinoid tumors mostly present as solid mass/cystic solid mass with calcification and delayed enhancement of heterogeneity on CT imaging, but the diagnosis depends on pathological diagnosis. Hence, raising awareness of the CT features of the rare tumor in the kidney may broaden the knowledge base of radiologists.

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Primary Renal Well-Differentiated Neuroendocrine Tumors: Analyis of Six Cases from a Tertiary Care Center in North India with Review of Literature

et al. 2022

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Well-differentiated renal neuroendocrine tumors are rare tumors. As their biologic behavior is not fully known, there is a need to know more about these cases. We performed a retrospective chart review of all the cases diagnosed with renal neuroendocrine tumors from January 2016 to December 2020 (five years) in order to understand their clinical features, morphological characteristics and outcome. We included six cases with mean age of 46.2 years (4 males) in our study. All patients underwent radical nephrectomy. Histologically all showed tumor disposed in nests and trabeculae and majority of the tumors belonged to well-differentiated neuroendocrine tumor Grade 1 (WHO criteria of gastoroenteropancreatic neuroendocrine neoplasms). Lymph node metastasis was seen in two cases at the time of clinical presentation. All the tumors were diffusely positive for neuroendocrine tumor markers (synaptophysin, chromogranin, NSE, CD56). Follow-up data was available in all cases with an average follow-up of two years and neither has shown evidence of metastasis or relapse till last follow-up. Role of morphological patterns and immunohistochemical markers is highlighted with the importance of including Ki-67 index in grading them to better understand their outcome.

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Primary renal carcinoid tumour with lung metastasis misdiagnosed as renal cell carcinoma

Cited by 4 publications

References 11 publications

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Clinical and Pathological Features of Primary Renal Well-Differentiated Neuroendocrine Tumor

Primary renal carcinoid tumors

Primary Renal Well-Differentiated Neuroendocrine Tumors: Analyis of Six Cases from a Tertiary Care Center in North India with Review of Literature

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