Primary signet ring cell carcinoma of gall bladder: report of an extremely rare histological type of primary gall bladder carcinoma

Ahmad, Zubair; Qureshi, Asim

doi:10.1136/bcr.04.2009.1782

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…In addition, the tumor grossly resembled linitis plastica and no discrete mass was noted. This was comparable to the reports by Agarwal et al [4], Czyszczon and Alatassi [13], Ahmad and Qureshi [16], and Padhiari et al [17]. On the other hand, many reported cases presented as discrete masses in a background of diffuse or focal wall thickening [9,11,14,18].…”

Section: Discussionsupporting

confidence: 87%

Poorly Cohesive Cell Carcinoma of the Gallbladder with Signet Rings and Neuroendocrine-Like Morphology: A Rare Incidental Histopathological Diagnosis with Lessons to Learn

Khader

Nsour²,

Alrubaye³

et al. 2019

Am J Case Rep

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Patient: Male, 46Final Diagnosis: Poorly cohesive cell carcinoma of the gallbladderSymptoms: Abdominal painMedication: —Clinical Procedure: Surgery and chemotherapySpecialty: PathologyObjective:Rare diseaseBackground:Poorly cohesive cell carcinoma of the gallbladder is extremely rare.Case Report:Here we present a case of a 46-year-old male with the clinical diagnosis of acute cholecystitis. The ultrasound showed gallbladder wall thickening and multiple stones. Cholecystectomy was performed, and the gross examination revealed linitis plastica-like thickening of the gallbladder wall. The microscopic examination revealed diffuse infiltration by a poorly differentiated tumor with signet rings. Another component with insular growth pattern and salt-and-pepper nuclei was present. Immunohistochemical findings were consistent with poorly cohesive cell carcinoma of the gallbladder. Imaging studies revealed regional lymph nodes involvement, in addition to peritoneal and liver metastases. The patient was given chemotherapy, and there was no evidence of disease progression at 4 months post-operation.Conclusions:This case supported that all cholecystectomy specimens must be examined. In addition, although poorly cohesive cell carcinoma was reported to be aggressive, the present case showed a protracted clinical course; this pointed to the need for early clinicoradiological suspicion. This is the first case of poorly cohesive cell carcinoma of the gallbladder with a neuroendocrine-like morphology that mimics mixed adenoneuroendocrine carcinoma. Immunohistochemistry is invaluable in such a scenario.

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Section: Discussionsupporting

confidence: 87%

Poorly Cohesive Cell Carcinoma of the Gallbladder with Signet Rings and Neuroendocrine-Like Morphology: A Rare Incidental Histopathological Diagnosis with Lessons to Learn

Khader

Nsour²,

Alrubaye³

et al. 2019

Am J Case Rep

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“…However, our case showed CK20, CDX-2, and MUC2 positivity in an immunohistochemical study. It has been reported that mucinous carcinomas, including signet ring cell carcinomas, often express the intestinal phenotype and/or the mixedmucinous phenotype [9,20]. We are not sure whether these phenotypes are related to the biological features such as prognosis or chemosensitivity.…”

Section: Discussionmentioning

confidence: 93%

A Case of Signet Ring Cell Carcinoma of the Gallbladder Which Was Treated by Aggressive Surgery and Intensive Adjuvant Chemotherapy

Hiraki

Ueda

Kai

et al. 2016

J Gastrointest Canc

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“…A previous case report indicated that the features of signet ring cell carcinoma include linitis plastica-like invasion and poor prognosis [15] , [16] , [17] , [18] , [19] . In the present case, circumferential invasion of the gallbladder wall spreading along biliary tract suggested a signet ring cell component of MC.…”

Section: Discussionmentioning

confidence: 99%

Mucinous carcinoma of the gallbladder with signet ring cells

Fukuda

Sakimoto

Narita

et al. 2017

Radiology Case Reports

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Most gallbladder carcinomas are adenocarcinomas, of which mucinous carcinoma (MC) is a rare pathologic subtype. Signet ring cells are seldom found in MCs. We report an extremely rare case of gallbladder MC with signet ring cells. This is the first radiological case report about this rare type of histologic entity with detailed discussion of imaging findings in the English literature. In addition to the features of MC, linitis plastica-like invasion, which is the key feature of signet ring cells, was confirmed by both imaging and histopathologic analysis. Furthermore, radiologists should know how the imaging findings of MC differ from those of other major subtypes of adenocarcinoma, as there is a risk of delays in diagnosis and underestimation of tumor spread.

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Primary signet ring cell carcinoma of gall bladder: report of an extremely rare histological type of primary gall bladder carcinoma

Cited by 6 publications

References 8 publications

Poorly Cohesive Cell Carcinoma of the Gallbladder with Signet Rings and Neuroendocrine-Like Morphology: A Rare Incidental Histopathological Diagnosis with Lessons to Learn

Poorly Cohesive Cell Carcinoma of the Gallbladder with Signet Rings and Neuroendocrine-Like Morphology: A Rare Incidental Histopathological Diagnosis with Lessons to Learn

A Case of Signet Ring Cell Carcinoma of the Gallbladder Which Was Treated by Aggressive Surgery and Intensive Adjuvant Chemotherapy

Mucinous carcinoma of the gallbladder with signet ring cells

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