Primary signet-ring cell carcinoma of the prostate

Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis

“…Breast [3] Large bowel [4] Appendix [5] Bladder, ureter, and pelvis [6] Ampulla of Vater [7] Esophagus [8] Prostate [9] Lung [10] Salivary glands [11] Sinonasal tract [12] Uterine cervix [13] Uterine corpus [14] Ovary (questionable) [15] Other neoplastic conditions Malignant lymphoma [16] Malignant melanoma [17] Basal cell carcinoma of skin [18] Squamous cell carcinoma of skin [19] Stromal tumor of ovary [20] Chondrosarcoma [21] Ependymoma [22] Malignant mesothelioma [23] Meningioma [24] Collecting duct carcinoma of kidney [25] Urothelial carcinoma of renal pelvis with collagenous spherulosis [26] Follicular adenoma and carcinoma of thyroid [27] Salivary gland adenoma [28] Pituitary adenoma [29] Carcinoid tumor of gallbladder [30] Pancreatic endocrine neoplasm [31] GIST [32] Peutz-Jeghers polyps [33] Epithelioid leiomyoma [34] Gastric schwannoma [35] Testicular seminoma [36] Nonneoplastic conditions Inflammatory/necrotizing conditions of gastrointestinal tract and gallbladder [33,[37][38][39][40][41][42][43]…”

Grading and Prognostic Significance of Urologic Carcinomas

“…They may also be classified as solid variant of the adenoid cystic carcinoma. Finally, there exist primary and secondary urothelial and squamous epithelial carcinomas in the prostate [115,[118][119][120],…”

A Primary Signet Ring Cell Carcinoma of the Prostate With Bone Metastasis With Impressive Response to FOLFOX and Cetuximab

“…5 The diagnosis of primary prostatic SRCC requires that 25% or more of the tumor be composed of signet ring cells. 6 There is a lack of data regarding the molecular etiology of signet ring cells. 7 In signet ring cell adenocarcinomas of the colon, a higher frequency of BRAF mutations (22% vs. 8.6%) and a lower frequency of KRAS mutations were observed.…”