Primary sinonasal mucosal melanoma: three different therapeutic approaches to inoperable local disease or recurrence and a review of the literature

Go, De Meerleer; Vermeersch, Hubert; M, van Eijkeren; Lemmerling, Marc; Caemaert, Jacques; B, De Naeyer; Delrue, Louke; Moerman, Mieke; Huys, J

doi:10.1097/00008390-199810000-00010

Cited by 20 publications

(22 citation statements)

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“…In contrast to the staging system, the primary tumor site was closely related to overall survival [19,20]. Tumors with involvement of the sinuses, whether confined to a single sinus or invading multiple sites, including the sinuses, were associated with significantly shorter overall survival times (table 1).…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological Features and Prognosis of Sinonasal Mucosal Malignant Melanoma: A Retrospective Study of 83 Cases in a Chinese Population

Zhu

Zou²,

Wang³

2016

ORL

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Aims: Sinonasal mucosal malignant melanoma (SNMMM) is a rare disease. The aim of the present study was to describe its clinicopathological features and prognosis in a Chinese population. Methods: Data on 83 SNMMM patients were collected and analyzed. A survival analysis was performed using the Kaplan-Meier method and a log-rank test. Results: The most common presenting symptoms of SNMMM were nasal obstruction, epistaxis, and bloody rhinorrhea. Histopathologically, 38 cases (45.78%) were amelanotic. Five cell types (epithelioid, undifferentiated, plasmacytoid, spindle, and clear) were identified. Positive staining for human melanoma black-45 and Melan-A was diagnostic of SNMMM. Advanced age, multiple tumor sites, and amelanotic-type SNMMM indicated a worse outcome (p = 0.008, p = 0.009, and p = 0.013, respectively). Neither adjuvant therapy nor the tumor stage was associated with overall survival. Conclusions: SNMMM is an uncommon disease with atypical symptoms. Its histopathological appearance is variable, especially in the amelanotic type. Thus, immunohistochemistry is important in the diagnosis, and it should be performed according to the histology.

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Section: Discussionmentioning

confidence: 99%

“…As shown in table 1, adjuvant radiotherapy and adjuvant chemotherapy seemed to make no difference in improving overall survival (p = 0.179) [19,24]. This may be due to the following reasons.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features and Prognosis of Sinonasal Mucosal Malignant Melanoma: A Retrospective Study of 83 Cases in a Chinese Population

Zhu

Zou²,

Wang³

2016

ORL

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“…Recent studies showed that surgery remains a treatment of choice in sinonasal malignant melanoma [35,112], whereas the use of radiotherapy in such cases remains controversial. De Meerleer et al [112] recommend the use of radiotherapy postoperatively and consider it as a good alternative in cases of inoperable disease.…”

Section: Treatment For Sinonasal Melanomasmentioning

confidence: 99%

“…De Meerleer et al [112] recommend the use of radiotherapy postoperatively and consider it as a good alternative in cases of inoperable disease. It is well known that the rates of lymphogenous and hematogenous metastases are high, which should be considered in preoperative tumor staging and operation planning.…”

Section: Treatment For Sinonasal Melanomasmentioning

confidence: 99%

Sinonasal Malignancy: What’s New?

Götte¹,

Hörmann²

2004

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Tumors of the nasal cavity are located at a complex anatomic site and show a huge histological diversity. Although dealing with a rare malignancy, the last decade has brought – besides new histological and clinical classifications – a variety of new insights into etiological agents, tumor biology and therapeutic concepts as well as valuable overviews of rare histological subtypes. This review tries to disentangle the different medical and scientific aspects of the most frequently encountered histological types of tumors in the nasal cavity and the paranasal sinuses. We concentrate on epidemiology, classification, etiology, cytogenetics and molecular genetics, outcome and prognosis as well as treatment modalities, as far as the past few years have brought considerable new insights. Our principal aim is to provide the clinician with important data from publications of the last decade.

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“…Es gibt jedoch signifikante ethnische Unterschiede: Das Risiko, an einem Schleimhautmelanom zu erkranken, ist zwar bei Kaukasiern 3-bis 6-fach höher als bei anderen Bevölkerungsgruppen [2,4,11], aufgrund der relativen Seltenheit kutaner Melanome beträgt jedoch der Anteil der primär sinunasalen Melanome in der japanischen Bevölkerung 7-11% [8,31,45], bei Afrikanern aus Uganda 2,6% [4,34]. Unter den malignen Neoplasien der sinunasalen Schleimhaut wiederum stellt das maligne Melanom einen Anteil von 3,6-9,1% [16,26,39].…”

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