Primary Sjögren's syndrome in men

Gondran, G.; Fauchais, Anne-Laure; Lambert, Marc; Ly, Kim-Heang; Launay, David; Queyrel, V.; Benazahari, H.; Liozon, É.; Loustaud‐Ratti, Véronique; Hachulla, É.; Jauberteau, Marie‐Odile; Hatron, Pierre‐Yves; Vidal, É.

doi:10.1080/03009740802001426

Cited by 43 publications

(48 citation statements)

References 38 publications

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“…Alveolitis displayed a strong tendency in the exploratory cohort which was confirmed after the meta-analysis, though the observation should be interpreted with caution considering the low numbers. A higher frequency of pulmonary involvement in male patients has been suggested by previous studies [34, 37], though statistical significance was not reached in these investigations. Also, lymphadenopathy has been associated with male sex [36, 37, 39].…”

Section: Discussioncontrasting

confidence: 62%

Difference in clinical presentation between women and men in incident primary Sjögren’s syndrome

et al. 2017

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BackgroundA more severe disease phenotype has been reported in men compared to women in several rheumatic diseases. However, studies have not conclusively established sex-related clinical features in primary Sjögren’s syndrome (pSS). In this study, we therefore investigated the clinical presentation of pSS in women and men at diagnosis.MethodsIncident, treatment naïve patients (n = 199) during a 5-year period in a specified area were prospectively included and examined for items of classification criteria for pSS as well as extraglandular manifestations (EGM). Serum was sampled at the time of diagnosis and anti-Ro52/SSA levels were measured by ELISA. Replication of significant findings was confirmed in an independent cohort of pSS patients (n = 377), and meta-analysis was performed.ResultsAn increased frequency of extraglandular manifestations in men was observed and replicated (p = 0.05, p = 0.0003, and p meta = 0.002). This related to pulmonary involvement, vasculitis, and lymphadenopathy being more common in men, for whom a lower age at diagnosis was observed in the exploratory cohort. Additionally, SSA-positive male patients had significantly higher levels of anti-Ro52 levels than their female counterparts in sera available for analysis (p = 0.02).ConclusionsOur analysis of two independent cohorts of incident pSS demonstrates that the presence and number of EGM are significantly more frequent among men with pSS than women at diagnosis. Importantly, around half of the male patients presented with more than one EGM at diagnosis, supporting the conclusion that pSS in men represents a more severe form of disease, regardless of the lower risk for men to develop pSS.

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Section: Discussioncontrasting

confidence: 62%

Difference in clinical presentation between women and men in incident primary Sjögren’s syndrome

et al. 2017

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“…Many studies have reported anti-SSA to be lower in men with primary SS, however a majority of studies have not found a consistent difference in serological status between men and women. [7][8][9][10][11][27][28][29][30] Also, we compared the proportion of seropositivity for either anti-SSA, anti-SSB, and/or ANA by gender, which has not been done before. Interestingly, men were four times more likely to be negative for all three tests compared to women.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have reported men to have a lower prevalence of positive serologic tests (such as anti-SSA and anti-SSB); however, there is no clear consensus regarding the frequency of extraglandular manifestations by gender. [7][8][9][10][11] Despite the higher incidence rate of SS in women, the mortality rate has been noted to be almost three times higher in men compared to women. 12 This disparity in the severity of clinical manifestations may be due to gender differences in the pathophysiology of the disease.…”

Section: Introductionmentioning

confidence: 99%

Ocular Complications of Primary Sjögren Syndrome in Men

Mathews

Hahn

Hessen

et al. 2015

American Journal of Ophthalmology

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“…Prevalence is higher in females than in males, with a female-to-male ratio of 9:1. Although SS may occur at any age, including in childhood, first symptoms appear at a mean age of 50 years [1,2]. The disease has a variable onset: glandular involvement with a dry syndrome and/or parotid tumefaction, or extraglandular manifestations, complicating and often delaying the diagnosis.…”

Section: Discussionmentioning

confidence: 99%