Primary Small Intestinal Lymphoma

Varghese, Cyril; Jose, C.C.; Jagu, Subhashini; Roul, R K

doi:10.1159/000227069

Cited by 13 publications

(9 citation statements)

References 4 publications

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“…Patients with bowel obstruction and intestinal perforation also need surgery. Therefore, patients with primary intestinal NHL received surgery with postoperative chemotherapy and/or radiotherapy [26,27]. Previous retrospective studies have found that radical surgery was helpful for survival.…”

Section: Discussionmentioning

confidence: 99%

Clinical prognostic analysis of 116 patients with primary intestinal non-Hodgkin lymphoma

et al. 2010

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The gastrointestinal tract is the most common extranodal invasion site of non-Hodgkin lymphoma (NHL). Primary gastrointestinal NHL is often discussed together in most survival analyses. Primary intestinal NHL is significantly different from primary gastric NHL with regard to clinical features, pathological subtype, treatment, and prognosis. In this article, we analyzed clinical and pathological characteristics of primary intestinal NHL, and we also explored prognostic factors for primary intestinal NHL. A retrospective analysis was carried out on clinical data from 116 cases of confirmed primary intestinal NHL. The Kaplan-Meier method was used for the survival analysis. A Cox model was used for a multivariate analysis. In 116 patients with primary intestinal NHL, 79 patients were men (68.1%) and 37 patients were women (31.9%). In the cases used in this study, 68 were B-cell NHL and 48 were T-cell NHL. The age, incidence of intestinal obstruction, B symptom and performance status (PS) were closely related with pathological subtype. One-year and two-year survival rates were 76.7 and 58.3%, respectively. The log-rank univariate analysis showed male patients, PS score greater than or equal to two, hypoproteinemia, intestinal perforation, T-cell type, late stage (III/IV), no radical surgery, and no chemotherapy had relatively poor prognoses. Cox multivariate analysis shown that gender (95.0% CI 0.218-0.721), pathological subtype (95.0% CI 1.484-4.179), and radical surgery (95.0% CI 0.110-0.394) were independent prognostic risk factor for primary intestinal NHL. Male patients, T-cell intestinal lymphoma, and no radical surgery had rapid clinical processes and poor prognoses.

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Section: Discussionmentioning

confidence: 99%

Clinical prognostic analysis of 116 patients with primary intestinal non-Hodgkin lymphoma

et al. 2010

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“…Due to the difficulty of accurate diagnosis and the potential for initial complications, in most cases of small bowel lymphoma the main tumour is surgically resected. 13,14 After the operation, not only can the histological diagnosis of the lymphomas be established but accurate staging can also be made. Chemotherapy and radiotherapy have been used alone or in combinations and in combination with surgery, 15 however the results have not been evaluated adequately and the efficacy of these procedures is not known.…”

Section: Introductionmentioning

confidence: 99%

Primary Small-bowel Non-Hodgkin's Lymphoma: A Study of Clinical Features, Pathology, Management and Prognosis

et al. 2007

J Int Med Res

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The records of 34 patients diagnosed with primary small bowel non-Hodgkin's lymphoma during a 10-year period between January 1996 and December 2005, including 27 cases for which complete follow-up records were available, were studied. Abdominal pain (70.6% of patients) was the main presenting symptom, followed by intestinal obstruction (38.2%). The most common primary site was the ileum (58.8%), followed by the jejunum (26.5%) and duodenum (17.6%); one case had tumours at two sites in the small bowel. Twenty-seven patients had small bowel B-cell lymphoma (24 diffuse large B-cell lymphoma; three mucosa-associated lymphoid tissue B-cell lymphoma) and seven patients had small bowel T-cell lymphoma. Cumulative survival in patients with small bowel B-cell lymphoma was higher than that in patients with small bowel T-cell lymphoma. Data on 16 male and eight female patients with diffuse large B-cell lymphoma showed that 62.5% of these patients presented with disease stages I or II and 37.5% with stages III or IV. Cumulative survival in patients at stages IE or IIE was significantly higher than that of patients at stages IIIE or IVE. Four of five patients who died from diffuse large B-cell lymphoma had abnormal levels of lactate dehydrogenase and serum albumin.

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“…La afectación por linfomas de células T es menos frecuente y tiene presentación heterogénea (6, 7). Se ha dicho clásicamente que el sitio más frecuente de linfoma gastrointestinal es el estómago, seguido por el intestino delgado, colon, ciego, esófago y afectación múltiple (8,9); sin embargo, Ha encontró en su revisión de 61 casos que la afectación del intestino delgado estaba presente del 20% al 54% de los linfomas gastrointestinales primarios (10). El sitio menos frecuente es el recto (11).…”

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Linfoma primario del intestino delgado: reporte de un caso y revisión de la literatura

Navia

2017

Rev. Colomb. Gastroenterol.

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ResumenEl tracto gastrointestinal es el sitio más frecuente de presentación del linfoma no Hodgkin (LNH) extraganglionar. Sin embargo, los linfomas primarios del tracto gastrointestinal son tumores raros y es mucho más frecuente la afectación de este tracto de manera secundaria en el curso de la enfermedad. Representan del 1% al 4% de los tumores malignos del tracto gastrointestinal, aunque tienen un curso, manejo y pronóstico muy diferente de los adenocarcinomas, por lo que es importante conocerlos y tenerlos en mente como un diagnóstico diferencial posible en el ejercicio clínico diario. Afectan más a los adultos jóvenes, con una mayor frecuencia en hombres (1). Reportamos el caso de una mujer de 47 años de edad con linfoma primario del intestino delgado, diagnosticado luego de múltiples consultas por síntomas abdominales y revisamos la literatura al respecto. Palabras claveLinfoma gastrointestinal primario; linfoma no Hodgkin extraganglionar; intestino delgado. AbstractThe gastrointestinal tract is the most frequent site of non-Hodgkin's lymphoma (NH) outside of the lymph nodes themselves. This tract is much more frequently compromised by tumors secondary to primary disease elsewhere in the body than by primary lymphomas of the gastrointestinal tract itself which are rare. They account for only one to four percent of malignant tumors of the gastrointestinal tract. Their development and prognoses are quite different from those of adenocarcinomas, hence their management must differ as well. It is important to understand them and keep them in mind in differential diagnosis in daily clinical practice. Young adults are most frequently affected, and men are more frequently affected than are women. We review the literature and report the case of a 47 year old woman with primary small bowel lymphoma that was diagnosed after several consultations due to abdominal symptoms. Key wordsPrimary gastrointestinal lymphoma, extraganglionic Non-Hodgkin's Lymphoma, small intestine. Reporte de casos INTRODUCCIÓNEl linfoma primario gastrointestinal y particularmente el del intestino delgado, que afectan preferentemente a los adultos jóvenes, no tienen un cuadro clínico típico ni hallazgos patognomónicos en la exploración física o en las imágenes. Por estas características, es un diagnóstico difícil, al que suele llegarse luego de múltiples estudios o en el escenario de una intervención quirúrgica urgente.

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Primary Small Intestinal Lymphoma

Cited by 13 publications

References 4 publications

Clinical prognostic analysis of 116 patients with primary intestinal non-Hodgkin lymphoma

Clinical prognostic analysis of 116 patients with primary intestinal non-Hodgkin lymphoma

Primary Small-bowel Non-Hodgkin's Lymphoma: A Study of Clinical Features, Pathology, Management and Prognosis

Linfoma primario del intestino delgado: reporte de un caso y revisión de la literatura

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