Primary solitary intracranial melanoma: Case report and review of the literature

Baena, Riccardo Rodriguez y; Gaetani, Paolo; Danova, Marco; Bosi, F.; Zappoli, F.

doi:10.1016/0090-3019(92)90208-5

Cited by 69 publications

(80 citation statements)

References 38 publications

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“…Primary CNS malignant melanoma has occurred in the spine, [4][5][6]10,11,19,26) suprasellar region, 3,6,24) cerebral region, 6,7,12,17) pineal region, 18) cerebellopontine angle, 13,25) spinal nerve root, 22,23) and leptomeninges. 16) Forty cases of primary spinal malignant melanoma have been reported, [4][5][6]10,11,19,26) including 14 with dissemination from the primary CNS malignant melanoma.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Nishihara

Sasayama

Kondoh

et al. 2009

Neurol. Med. Chir.(Tokyo)

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A 49-year-old man was admitted suffering from headache persisting for a month. He had a history of primary spinal intramedullary malignant melanoma at the T6 level 18 years previously, which had remained stable for 18 years. Magnetic resonance imaging revealed central nervous system (CNS) dissemination of malignant melanoma. Whole brain radiation therapy (30 Gy), local radiation therapy (15 Gy), and routine intrathecal injection of interferon beta were performed. The progression of CNS dissemination of malignant melanoma was controlled without neurological deterioration for 38 months. The prognosis for primary CNS malignant melanomas better than that for cutaneous melanoma. However, the clinical course is still unknown, and CNS dissemination is regarded fatal. The unusually long survival in the present case indicates the effectiveness of the combined radiotherapy and interferon therapy.

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Section: Discussionmentioning

confidence: 99%

Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Nishihara

Sasayama

Kondoh

et al. 2009

Neurol. Med. Chir.(Tokyo)

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“…The common sites for a primary CNS melanoma are, lobar (53.1%), posterior fossa (17.3%) and pineal region (13.6%) (2). Primary melanoma of the cerebellopontine angle is very rare and was first described in 1948 by Bailey (2). There are only seventeen CP angle melanoma cases reported including the present case (Table I).…”

Section: Introductionmentioning

confidence: 72%

“…They vary from benign to malignant. Virchow described the first case of primary diffuse intracranial melanoma in 1859 and Oogle (2,14) reported the first case of primary intracranial solitary melanoma in 1899. Since then, there have been only 250 cases of primary intracranial melanoma reported by WHO (8).…”

Section: Introductionmentioning

confidence: 99%

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Primary cerebellopontine angle melanoma: case report and review

Bhandari

Alapatt²,

Govindan³

et al. 2010

Turkish Neurosurgery

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Primary melanomas at the cerebellopontine (CP) angle are extremely rare and considered a diagnostic dilemma. With only 16 prior cases reported so far, there is not enough material in world literature. We report a 29-year-old male who presented with vertigo, headache and features of lower cranial nerve involvement with MRI revealing a melanotic lesion at CP angle. The patient underwent right suboccipital craniectomy and only subtotal excision of the tumor was possible. Histopathologically it turned out to be malignant melanoma. Since a thorough search for any possible primary was futile, it was considered a primary melanoma. Patient was given adjuvant radiotherapy. Ten months later, he presented with weakness and multiple spinal metastases and two months later he succumbed to his disease. We did a comprehensive review of literature about various melanocytic tumors at the CP angle. Pathologically, melanocytic tumors range from benign melanocytomas to malignant melanoma with variable prognosis. The clinical presentation depends upon whether the lesions are diffuse or discrete. Surgery is the primary modality of treatment and the amount of tumor excised is related to the prognosis. We conclude the discussion with a novel classification for melanotic tumors of CNS and the current diagnostic pathway for a melanotic lesion at the CP angle.KeywoRds: Cerebellopontine angle melanoma, Intracranial melanoma, Primary melanoma ÖZ Serebellopontin (CP) açıda primer melanomlar çok nadirdir ve tanısal bir ikilem olarak değerlendirilir. Şu ana kadar sadece 16 vaka bildirilmiştir ve henüz dünya literatüründe yeterli bilgi yoktur. Baş dönmesi, başağrısı ve alt kraniyal sinir tutulumu bulguları ile gelen ve MRG'nin CP açıda bir melanotik lezyon gösterdiği 29 yaşında bir erkek hasta sunuyoruz. Hastaya sağ suboksipital kraniektomi yapıldı ve tümör ancak subtotal olarak eksize edilebildi. Histopatolojik olarak malign melanom olduğu saptandı. Herhangi bir olası primer açısından kapsamlı bir araştırma yapmak anlamsız olduğundan primer melanom kabul edildi. Hastaya adjuvan radyoterapi verildi. Hasta on ay sonra zayıflık ve çok sayıda spinal metastaz ile geldi ve iki ay sonra hastalığı nedeniyle öldü. CP açıda çeşitli melanostik tümörler hakkında literatürü kapsamlı olarak araştırdık. Patolojik olarak melanostik tümörler benign melanositomlardan değişken prognozlu malign melanoma kadar değişmektedir. Klinik sunum lezyonların difüz veya tek tek olmasına göre değişir. Cerrahi temel tedavi modalitesidir ve eksize edilen tümör miktarı prognozla ilişkilidir. Tartışmayı MSS melanotik tümörleri için yeni bir sınıflandırma ve CP açıda bir melanotik lezyon için mevcut diagnostik yaklaşımı sunarak bitiriyoruz.ANAHTAR sÖZCÜKLeR: Serebellopontin açı melanomu, İntrakraniyal melanom, Primer melanom

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“…2,6,17 ± 21 The most important reviews on this subject clearly distinguish four di erent categories of primary melanoma a ecting the Nervous System: (a) di use leptomeningeal melanomatosis, with in®ltration of the leptomeninges of the brain and spinal cord; (b) discrete spinal cord melanomas; (c) primary intracranial isolated melanomas; and (d) melanosis of the meninges of the brain or spinal cord associated with cutaneous pigmentation (neurocutaneous melanosis). 9 Among these categories, primary spinal melanoma represents a very rare clinicopathological entity. It was ®rst reported by Hirschberg in 1906.…”

Section: Introductionmentioning

confidence: 99%

Primary intraparenchymatous spinal cord melanoma

Vaquero

Pedrosa

1998

Spinal Cord

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A case of primary melanoma arising from the spinal cord parenchyma at the Th 10-11 level, in a 50-year-old female, is presented. In this patient, Magnetic Resonance Imaging (MRI) showed an intraparenchymatous lesion, with rounded borders, and an associated intramedullary cyst. On the basis of these ®ndings and the long duration of symptoms, an erroneous preoperative diagnosis of intramedullary ependymoma was made.

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Primary solitary intracranial melanoma: Case report and review of the literature

Cited by 69 publications

References 38 publications

Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Long-Term Survival After Surgical Resection of Primary Spinal Malignant Melanoma -Case Report-

Primary cerebellopontine angle melanoma: case report and review

Primary intraparenchymatous spinal cord melanoma

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