Primary somatosensory cortex is actively involved in pain processing in human

Kanda, Masutaro; Nakagawa, Takashi; Ikeda, Akio; Ohara, Shuichi; Kunieda, Takeharu; Fujiwara, Naohito; Yazawa, Shogo; Sawamoto, Nobukatsu; Matsumoto, Riki; Taki, Waro; Shibasaki, Hiroshi

doi:10.1016/s0006-8993(99)02274-x

Cited by 177 publications

(100 citation statements)

References 48 publications

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“…The pain matrix is subdivided into medial and lateral pain systems; this distinction, which is based on the projection sites from medial or lateral thalamic structures to the cortex, is probably an oversimplification of the networks involved but it is a useful means for grouping brain regions that appear to have similar roles in pain perception [12]. For instance, the lateral pain system (S1, S2) seems principally involved in discriminating the location and the intensity of painful stimuli [23,24], whereas the ACC [25,26] is involved in the affective (cognitive-evaluative) component of pain. The insula, however, encodes both the intensity [6,12,27] and the laterality [28,29] of painful and non-painful thermal stimuli, but may also have a role in affective pain processing [30][31][32][33].…”

Section: Afferent Pathwaysmentioning

confidence: 99%

Nociception and autonomic nervous system

et al. 2013

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The International Association for the Study of Pain (IASP) defines pain as ''an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage''. Pain may also be experienced in absence of noxious stimuli and together with temperature and other bodily feelings constitute the interoception redefined as the sense of the physiological condition of the entire body, not just the viscera. The main characteristic of these feelings is the affective aspect. Emotion, motivation, and consequent behavior connected with these feelings characterize their homeostatic role. This implies an interaction between neural structures involved in pain sensation and autonomic control. The aim of this review is to focus on pain perception, mainly on pain matrix structures' connections with the autonomic nervous system.

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Section: Afferent Pathwaysmentioning

confidence: 99%

Nociception and autonomic nervous system

et al. 2013

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“…3, 4). The involvement of S1 and S2 in the cortical processing of nociceptive input in humans has been reported in a large number of studies (Ploner et al, 1999;Kanda et al, 2000;Porro, 2003;Youell et al, 2004;Apkarian et al, 2005;Plaghki and Mouraux, 2005;Tracey and Mantyh, 2007). However, only a few studies have examined explicitly whether the processing of nociceptive input in S1 and S2 is organized in parallel or serially.…”

Section: Parallel Processing Of Non-nociceptive Input In S1 and S2mentioning

confidence: 99%

“…In contrast with the large body of evidence investigating the serial versus parallel processing of non-nociceptive somatosensory input in S1 and S2 in higher primates, only few studies, all relying on magnetoencephalography, have suggested a parallel processing of nociceptive somatosensory input in S1 and S2 in humans (Ploner et al, 1999;Kanda et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Parallel Processing of Nociceptive and Non-nociceptive Somatosensory Information in the Human Primary and Secondary Somatosensory Cortices: Evidence from Dynamic Causal Modeling of Functional Magnetic Resonance Imaging Data

Liang

Mouraux²,

Iannetti³

2011

Journal of Neuroscience

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Several studies have suggested that, in higher primates, nociceptive somatosensory information is processed in parallel in the primary (S1) and secondary (S2) somatosensory cortices, whereas non-nociceptive somatosensory input is processed serially from S1 to S2. However, evidence suggesting that both nociceptive and non-nociceptive somatosensory inputs are processed in parallel in S1 and S2 also exists. Here, we aimed to clarify whether or not the hierarchical organization of nociceptive and non-nociceptive somatosensory processing in S1 and S2 differs in humans. To address this question, we applied dynamic causal modeling and Bayesian model selection to functional magnetic resonance imaging (fMRI) data collected during the selective stimulation of nociceptive and non-nociceptive somatosensory afferents in humans. This novel approach allowed us to explore how nociceptive and non-nociceptive somatosensory information flows within the somatosensory system. We found that the neural activities elicited by both nociceptive and non-nociceptive somatosensory stimuli are best explained by models in which the fMRI responses in both S1 and S2 depend on direct thalamocortical projections. These observations indicate that, in humans, both nociceptive and non-nociceptive information are processed in parallel in S1 and S2.

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“…The question as to whether pain perception is mainly processed in the hand area of SI or SII, or in both areas, has remains to be solved (12,13). The recent study by means of MEGand subdural recording for pain related evoked potentials suggested that SI is also actively involved in pain perception (14). The present study maysupport that SI is actively involved in pain perception.…”

Section: Discussionmentioning

confidence: 53%