Primary spinal epidural diffuse large B-cell lymphoma

Jagtap, Sujit; Patil, Akshay; Kesavdas, C.; Radhakrishnan, Natasha; Soni, Himanshu; Satish, Kandraju Sai

doi:10.4103/0028-3886.121940

Cited by 6 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 65 studies 3,13,17,30–91 with 72 cases of primary spinal B-cell lymphoma were included (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Surgical Intervention for Primary B-cell Lymphoma of the Spine

Gendreau,

Patel,

Brown

et al. 2023

Clinical Spine Surgery: A Spine Publication

View full text Add to dashboard Cite

Study Design: Systematic review and meta-analysis. Objective: To perform a systematic review of the clinical symptoms, radiographic findings, and outcomes after spinal decompression in B-cell lymphoma. Summary of Background Data: B-cell lymphoma is a potential cause of spinal cord compression that presents ambiguously with nonspecific symptoms and variable imaging findings. Surgical decompression is a mainstay for both diagnosis and management, especially in patients with acute neurological deficits; however, the efficacy of surgical intervention compared with nonoperative management is still unclear. Methods: The databases of Medline, PubMed, and the Cochrane Database of Systemic Reviews were queried for all articles reporting spinal B-cell lymphoma. Data on presenting symptoms, treatments, survival outcomes, and histologic markers were extracted. Using the R software “survival” package, we generated bivariate and multivariate Cox survival regression models and Kaplan-Meier curves. Results: In total, 65 studies were included with 72 patients diagnosed with spinal B-cell lymphoma. The mean age was 56.22 (interquartile range: 45.00–70.25) with 68% of patients being males and 4.2% of patients being immunocompromised. Back pain was the most common symptom (74%), whereas B symptoms and cauda equina symptoms were present in 6% and 29%, respectively. The average duration of symptoms before presentation was 3.81 months (interquartile range: 0.45–3.25). The most common location was the thoracic spine (53%), with most lesions being hyperintense (28%) on T2 magnetic resonance imaging. Surgical resection was performed in 83% of patients. Symptoms improved in 91% of patients after surgery and in 80% of patients treated nonoperatively. For all 72 patients, the overall survival at 1 and 5 years was 85% (95% CI: 0.749–0.953; n = 72) and 66% (95% CI: 0.512–0.847; n = 72), respectively. Conclusion: Although surgery is usually offered in patients with acute spinal cord compression from B-cell lymphoma, chemotherapy and radiation alone offer a hopeful alternative to achieve symptomatic relief, particularly in patients who are unable to undergo surgery.

show abstract

“…A total of 65 studies 3,13,17,30–91 with 72 cases of primary spinal B-cell lymphoma were included (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Surgical Intervention for Primary B-cell Lymphoma of the Spine

Gendreau,

Patel,

Brown

et al. 2023

Clinical Spine Surgery: A Spine Publication

View full text Add to dashboard Cite

show abstract

“…PSEL is a potentially curable disease with good clinical outcomes and prognosis when diagnosed early and treated with surgery and multimodality treatment. There are two pathophysiological hypotheses of this disease that originated from the lymphoid tissue of venous flexus inside the paravertebral lymphoid rest and originated from paraspinal, vertebral, and retroperitoneal tissue spread along the intervertebral foramen [ 7 8 13 14 ]. In this case, it is believed to have been spread along the intervertebral foramen of the cervical and thoracic segments originating from paraspinal lymphoid tissue and pleural tissue.…”

Section: Discussionmentioning

confidence: 99%

A Rare Occurrence of Primarily Extranodal Spinal Epidural Lymphoma With Spinal Cord Compression and Invasion to the Thoracic Cavity

Seok

Madadi

Mosleh

et al. 2023

Brain Tumor Res Treat

View full text Add to dashboard Cite

A 41-year-old man suffered from progressive radiculomyelopathy caused by spinal epidural mass primarily encasing the spinal cord at the cervicothoracic vertebrae that extended into the thoracic cavity through the neural foramen. An urgent decompressive laminectomy and epidural tumor resection were performed to prevent neurological deterioration and effective spinal cord decompression. The histopathologic diagnosis was diffuse large B-cell lymphoma. As first-line treatment for stage II extranodal lymphoma, he received 6 cycles of R-CHOP (rituximab/cyclophosphamide, hydroxydaunorubicin, Oncovin, and prednisone) chemotherapy. Consequently, follow-up positron-emission tomography CT and MR images demonstrated a complete metabolic response (Deauville score 1). This rare occurrence of primarily extranodal spinal epidural lymphoma with limited disease will be presented in a literature review.

show abstract