Primary squamous carcinoma of the thyroid–a case report

Abstract

We report a well-documented case of fatal thyroid cancer with histopathological characteristics of primary squamous carcinoma. A possible primary tumour elsewhere was excluded. The possible histogenesis of this unusual tumour and the therapy of choice are briefly discussed.

Primary squamous cell carcinoma of the thyroid: Case report and systematic review of the literature

“…Some 17 publications with 48 cases without complete work-up, including CT-scan, panendoscopy, immunohistochemistry and double citations were excluded [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]. Finally, 35 papers and ours reporting on 50 patients were available for analysis [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57], [58].

Fig. 2The flow chart of identified studies.

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Primary squamous cell carcinoma of the thyroid gland: an entity with aggressive clinical behaviour and distinctive cytokeratin expression profiles

“…To date, approximately 130 cases of primary squamous cell carcinoma of the thyroid gland have been reported in the English literature, with the majority being case reports 7–34 . Thus, clinicopathological features of primary squamous cell carcinoma of the thyroid gland are not well defined.…”

Primary Squamous Cell Carcinoma of the Thyroid Arising in Hashimoto's Thyroiditis in an Adolescent

“…Most patients are in the 5th and 6th decades of life, with ages ranging from 30 to 89 years (mean age, 71 years). The majority of squamous cell carcinomas of the thyroid are large, rapidly growing, and poorly differentiated neoplasms that follow an aggressive clinical course similar to that of anaplastic spindle and giant cell carcinoma [1,5–15]. Patients often present with signs and symptoms of upper airway compression or invasion [3,4].…”