Primary squamous cell carcinoma of the endometrium: Two cases and a review of the literature

Goodrich, Sarah; Kebria-Moslemi, Mehdi; Broshears, John R.; Sutton, Gregory P.; Rose, Peter G.

doi:10.1002/dc.22814

Cited by 19 publications

(18 citation statements)

References 8 publications

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“…Given the rarity of this condition, there is no consensus for the best way to manage these patients. Many different treatment options have been reported in the literature: surgical resection with or without adjuvant chemotherapy/radiotherapy 9. Survival data of patients affected by PESCC are scarce and controversial.…”

Section: Discussionmentioning

confidence: 99%

Chronic uterine inversion with malignancy mimicking carcinoma cervix

Girish

Davis²

2019

BMJ Case Rep

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Chronic non-puerperal uterine inversion is a rare event, with only a handful of cases reported in literature. We report a case of a 64-year-old postmenopausal woman who presented with complaints of mass per vaginam and postmenopausal bleeding. On examination, she appeared to have third-degree cervical descent with an irregular growth seen over what appeared to be the cervix, biopsy of which showed keratinising squamous cell carcinoma. Subsequently, an inverted uterus was diagnosed at laparotomy with an irregular growth seen over the inverted portion of the uterine fundus, histopathology of which revealed squamous cell carcinoma of endometrium.

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Section: Discussionmentioning

confidence: 99%

Chronic uterine inversion with malignancy mimicking carcinoma cervix

Girish

Davis²

2019

BMJ Case Rep

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“…(Bures) And In contrast to the type I Endometrioid adenocarcinoma of the endometrium, PSCCE is not hormonally sensitive, suggesting a unique pathogenesis [9]. Given the rarity of this condition, there is no consensus for the best way to manage these patients with PSCCE [10]. Many different treatment options have been reported in the literature: surgical resection with or without adjuvant chemotherapy/radiotherapy [10].…”

Section: Discussionmentioning

confidence: 99%

“…Given the rarity of this condition, there is no consensus for the best way to manage these patients with PSCCE [10]. Many different treatment options have been reported in the literature: surgical resection with or without adjuvant chemotherapy/radiotherapy [10]. Survival data of patients affected by PESCC are scarce and controversial.…”

Section: Discussionmentioning

confidence: 99%

Sacrococcygeal chondroid chordoma: a case report and literature review

Alami¹,

Farhan²,

Houmada³

et al. 2018

Pan Afr Med J

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In this paper, we report a case of primary squamous cell carcinoma of the endometrium (PSCCE) with a literature review. A 64-year-old woman was admitted because of postmenopausal bleeding. The gynecological exam found bleeding from the endocervix. The pelvic ultrasound objectified uterine regular contours, endometrial thickened was 10 mm, the presence of an intra cavitary lesion measuring 56/70 mm. The diagnostic hysteroscopy revealed a whitish appearance taking all the uterine cavity making evoke a tumor of the endometrium. Pelvic MRI showed a tumor limited to the uterine corpus endometrium (invasion by more than 50% of the myometrium) without invasion of the cervix. Radical hysterectomy, bilateral salpingo-oophorectomy, and lymph nodes dissection were performed. Grossly, the endometrial carcinoma was polypoid tumor occupying the entire uterine cavity. Histologically, the diagnosis of SCC was retained. No adenocarcinoma element was recognized. Neither squamous metaplasia nor dysplasia was recognized. No ectopic cervical tissue was found. The SCC was found to invade into deeper one half of the myometrium. No tumor cells were seen in other sites including the cervix, ovaries, parameters, and lymph nodes. The patients was FIGO 2009 stage IB (pT1B, N0), and was treated with adjuvant radiation. The patient had a disease progression in the pelvis 3 months after the irradiation. We reported a case of PSCCE which can help to enrich the literature for the treatment and prognosis of this disease.

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“…PSCCE tends to occur in postmenopausal, nulliparous, white women who usually present at age 67 yr with postmenopausal bleeding and discharge. Treatment consists of a total abdominal hysterectomy (TAH) with bilateral salpingo-oophorectomy (BSO); adjuvant chemotherapy and radiation therapy may be used (2,4). Treatment consists of a total abdominal hysterectomy (TAH) with bilateral salpingo-oophorectomy (BSO); adjuvant chemotherapy and radiation therapy may be used (2,4).…”

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confidence: 99%

Primary Squamous Cell Carcinoma of the Endometrium

Bures

Nelson

Duan

et al. 2013

International Journal of Gynecological Pathology

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Molecular alterations leading to cell cycle dysregulation in primary squamous cell carcinoma of the endometrium (PSCCE) and correlation with clinical outcome are incompletely described. Molecular variables of 5 cases of PSCCE were compared with 8 controls of endometrial endometrioid adenocarcinoma and correlated with overall survival. Immunohistochemical expression of pRB, p18, p19, CDK4, CDK6, Cyclin D1, p16, HPVE7, pTEN, ER, PR, and p53 was independently scored (intensity: 0-3 and proportion: 0-5) twice by 2 reviewers. Scores were averaged and expression was categorized as positive or negative. Human papillomavirus (HPV) DNA amplification and Braf and Kras mutations were assessed by polymerase chain reaction. Distribution differences between cases and controls were tested for significance using χ/Fisher exact tests. Differences in overall survival and correlation with variables were calculated using Kaplan-Meier and tested for significance using log rank tests. All cases and controls were mostly positive for pRB, p19, CDK6, and Cyclin D1 and mostly negative for p16, p18, CDK4, HPVE7, pTEN, and p53. Cases were mostly negative for ER and PR, whereas controls were mostly positive. All were negative for HPV DNA amplification and Braf mutations. One case and 2 controls had a Kras mutation. Only the ER and PR distribution difference was significant (P=0.03 and 0.02, respectively) and differences in overall survival did not correlate with any variable. PSCCE has molecular alterations involving the pRB-Cyclin D1-CDK4/6-p16 pathway, and pTEN. In contrast to the type I EACC, PSCCE is not hormonally sensitive, suggesting a unique pathogenesis.

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Primary squamous cell carcinoma of the endometrium: Two cases and a review of the literature

Cited by 19 publications

References 8 publications

Chronic uterine inversion with malignancy mimicking carcinoma cervix

Chronic uterine inversion with malignancy mimicking carcinoma cervix

Sacrococcygeal chondroid chordoma: a case report and literature review

Primary Squamous Cell Carcinoma of the Endometrium

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