Primary Squamous Cell Carcinoma of Urinary Bladder – A Rare Histological Variant

Jagtap, Sunil Vitthalrao; Sarda, Sharda; Demde, Rakesh B.; Huddedar, Anil; Jagtap, Swati Sunil

doi:10.7860/jcdr/2015/14099.6746

Cited by 6 publications

(10 citation statements)

References 8 publications

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“…To the best of our knowledge, there is no report of hypercalcemia caused by the lymph node metastasis of bladder cancer, which was the only detectable metastatic lesion in our case after performing radical cystectomy. A few published reports suggest that hypercalcemia associated with bladder cancer is related to the presence of high‐grade UC or SCC component and the bladder cancer of this case comprised squamous differentiated UC …”

Section: Discussionsupporting

confidence: 59%

“…Hypercalcemia associated with malignancy is most commonly observed in patients with breast cancer, lung cancer, multiple myeloma, and renal cell carcinoma. Histologically, high‐grade UC, SCC, and sarcoma have the potential to cause hypercalcemia . Hypercalcemia associated with bladder cancer without bone metastasis or massive tumor is rare, and primarily, individual case reports of hypercalcemia have been reported .…”

Section: Introductionmentioning

confidence: 69%

“…A few published reports suggest that hypercalcemia associated with bladder cancer is related to the presence of high-grade UC or SCC component and the bladder cancer of this case comprised squamous differentiated UC. 2,3,5 Hypercalcemia associated with invasive bladder cancer before treatment may be resolved by radical cystectomy. However, there is no preferred treatment for hypercalcemia associated with the recurrence or metastasis of bladder cancer following cystectomy owing to its rarity.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, high-grade UC, SCC, and sarcoma have the potential to cause hypercalcemia. [1][2][3] Hypercalcemia associated with bladder cancer without bone metastasis or massive tumor is rare, and primarily, individual case reports of hypercalcemia have been reported. 4,5 Here, we report the case of a patient with hypercalcemia caused by the lymph node metastasis of bladder cancer following radical cystectomy.…”

Section: Introductionmentioning

confidence: 99%

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Hypercalcemia associated with lymph node metastasis following radical cystectomy for bladder cancer

et al. 2018

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Introduction A part of hypercalcemia is a paraneoplastic syndrome. Its association with lymph node metastasis of bladder cancer has been infrequently reported in the literature. Case presentation A 75‐year‐old male presented with gross hematuria and was diagnosed with bladder cancer without metastasis. Following neoadjuvant chemotherapy, radical cystectomy was performed. The surgical margin was negative. The bladder cancer was classified as pT3bN0 and mainly constituted squamous differentiated urothelial carcinoma and sarcomatoid variant. His perioperative serum calcium levels were normal. At 6 months of surgery, computed tomography revealed lymph node enlargement, and additional 2 weeks later, he developed epileptic seizures with a serum corrected calcium level of 18.7 mg/dL. He was diagnosed with hypercalcemia caused by the lymph node metastasis of bladder cancer. Despite receiving several supportive therapies for 22 days, he died. Conclusion Hypercalcemia associated with bladder cancer is highly resistant to existing therapy, particularly when caused by cancer metastasis.

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Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hypercalcemia associated with lymph node metastasis following radical cystectomy for bladder cancer

et al. 2018

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“…On radiological evaluation showed internal iliac group of nodal involvement. According to WHO/ISUP classification of tumors of urinary bladder 2004, our case was invasive neoplasm-SCC grade II and stage T2N1M1 [14].…”

Section: Gross Pathological Features Of Sccmentioning

confidence: 99%

Squamous Cell Carcinoma of the Urinary Bladder: Clinicopathological and Molecular Update

Jagtap¹,

Jagtap²,

Kaur³

et al. 2021

ann urol oncol

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Urinary bladder cancer is one of the most prevalent cancers worldwide.Squamous Cell Carcinoma (SCC) is an uncommon subtype of urinary bladder carcinoma.It is a malignant epithelial neoplasm arising in the urinary bladder demonstrating a pure squamous cell phenotype. On histopathology it is considered when tumor is showing pure squamous morphology without any component of conventional urothelial carcinoma. The SCC is a histologically distinct form of cancer. It arises from the uncontrolled multiplication of cells showing particular cytological or tissue architectural characteristics of squamous cell differentiation, such as the presence of keratin, tonofilament bundles or desmosomes. Majority of bladder SCC are high grade, high stage tumors with most cancers having muscle invasion at the time of diagnosis while overall about 80% of bladder cancers are non-muscle invasive bladder cancer at diagnosis.COX-2 is markedly expressed in all SCCs. An increased COX-2 level induces the development of SCC of the bladder affecting many biological features of this tissue including apoptosis, cell adhesion, angiogenesis and invasiveness.TERT promoter mutations, commonly found in conventional urothelial carcinoma, are also highly prevalent in urinary bladder squamous cell carcinoma suggesting a common tumorgenesis and potential utility as a molecular urine-based-screening assay.This review summarizes the current features related to clinical , pathological, and molecular features of SCC of urinary bladder.

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Refractory paraneoplastic hypercalcaemia responding to cinacalcet

2022

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A woman in her late 70s presented with an increased frequency of micturition, suprapubic pain and weight loss. She was found to be having advanced cancer of the urinary bladder, coupled with bilateral hydronephrosis.Whilst undergoing surgical intervention for the latter, she was incidentally found to be having hypercalcaemia. This was found to be paraneoplastic in nature, possibly due to elevated parathyroid hormone related peptide with no evidence of bone metastasis. The histology of the resected tumour revealed squamous and sarcomatoid differentiation. Her hypercalcaemia initially responded to intravenous fluids, and later on zolendronate,but the problem recurred again, with the response to a repeat dose of zolendronate and even denosumab being unsatisfactory. As a last resort cinacalcet was started, and although there was a good response to it, our patient sadly died a few weeks later.We believe our case to be the first case of hypercalcaemia associated with isolated bladder cancer which showed a successful response to cinacalcet.

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Primary Squamous Cell Carcinoma of Urinary Bladder – A Rare Histological Variant

Cited by 6 publications

References 8 publications

Hypercalcemia associated with lymph node metastasis following radical cystectomy for bladder cancer

Hypercalcemia associated with lymph node metastasis following radical cystectomy for bladder cancer

Squamous Cell Carcinoma of the Urinary Bladder: Clinicopathological and Molecular Update

Refractory paraneoplastic hypercalcaemia responding to cinacalcet

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