The impacts of local and neighborhood contexts on population health have attracted enormous research attention in the past two decades. Researchers are investigating how diverse place characteristics, such as environmental pollution; residential segregation; and access to recreational, health, and social services and employment opportunities, affect people's health and well-being, as well as how health in turn shapes people's lives and livelihoods. Much of the focus is on the local scale, while the regional scale-the primary focus of regional scientists-has attracted less attention. At the same time, regional science work has not generally addressed health and health care, despite the importance of these issues to regional economies, populations, and economic and social development processes. Health is crucial for sustaining a productive and innovative workforce, providing a key cornerstone for productive and reproductive activities that are embedded within regional economies. Regional development processes affect population health through complex linkages to incomes, occupations, infrastructure developments, and myriad other socioeconomic and contextual factors. In addition, medical services and other health-related industries have emerged in the past several decades as critical components of local economies, providing employment, income, innovation, and other outputs that ripple through local and regional economies. In the U.S., health care accounts for 17% of GDP, making it one of the largest economic sectors.