1999
DOI: 10.1016/s0167-4838(99)00198-3
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Primary structure and unusual carbohydrate moiety of functional unit 2-c of keyhole limpet hemocyanin (KLH)

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Cited by 29 publications
(20 citation statements)
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“…Furthermore, immunization with KLH-induced antibodies cross-reacting with the Thomson-Friedenreich (T) antigen. This finding has been later interpreted as an indication of O-glycosylation of KLH (47). To our knowledge, however, O-glycans have neither been isolated from KLH nor characterized yet.…”
Section: Discussionmentioning
confidence: 94%
“…Furthermore, immunization with KLH-induced antibodies cross-reacting with the Thomson-Friedenreich (T) antigen. This finding has been later interpreted as an indication of O-glycosylation of KLH (47). To our knowledge, however, O-glycans have neither been isolated from KLH nor characterized yet.…”
Section: Discussionmentioning
confidence: 94%
“…25). Indeed, carbohydrate analysis of keyhole limpet hemocyanin has revealed that in contrast to all other functional units, KLH1-c is devoid of any sugar moiety, whereas KLH2-c lacks N-linked carbohydrates yet contains O-linked sugars (26). Functional unit HtH1-h has two sugar sites in quite unusual positions ( Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have reported methylated sugars as constituents of glycoproteins in other organisms, including nematodes, yeasts, snails, algae, and planarians (51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62). For example, in the study by Hall et al (52), 3-O-MeGal was found in hemocyanin from Helix pomatia (Roman snail), and both 3-O-MeGal and 3-O-MeMan were identified in hemocyanin from Lymnaea stagnalis (a freshwater snail).…”
Section: Discussionmentioning
confidence: 99%
“…For example, in the study by Hall et al (52), 3-O-MeGal was found in hemocyanin from Helix pomatia (Roman snail), and both 3-O-MeGal and 3-O-MeMan were identified in hemocyanin from Lymnaea stagnalis (a freshwater snail). In mollusks, 3-O-MeMan and/or 3-O-MeGal were found in some hemocyanins (53)(54)(55)(56), and in nematodes, O-linked glycans were shown to contain 2-O-methylated fucose (57,58). However, only a few studies have investigated the overall glycan structure (composition and monosaccharide sequence) of molecules that contain methylated sugars.…”
Section: Discussionmentioning
confidence: 99%