Primary synovial sarcoma of the kidney

Perlmutter, Adam E.; Saunders, S. J.; Zaslau, Stanley; Chang, Wenguang; Farivar-Mohseni, Hesam

doi:10.1111/j.1442-2042.2005.01150.x

Cited by 33 publications

(28 citation statements)

References 9 publications

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“…SSs usually stain positively for bcl-2, CD99/Mic2, CD56, vimentin, and focally for EMA. However, SSs usually stain negatively for desmin, actin, WT-1, S-100, CD34 and CD31 [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. In the differential diagnosis, the positivity for both CD99 and CD56, and the focal positivity for EMA confirm the diagnosis of SS.…”

Section: Discussionmentioning

confidence: 99%

“…Biphasic, monophasic spindle cell and poorly differentiated variants are histological subtypes of SS. Poorly differentiated SS is composed of sheets of undifferentiated round cells with hyperchromatic nuclei and frequent mitoses, and shows the poorest outcome [8,9,10,11,12,13,14]. Biphasic SS can be diagnosed with the presence of both epithelial and spindle cell components.…”

Section: Discussionmentioning

confidence: 99%

“…In the differential diagnosis, the positivity for both CD99 and CD56, and the focal positivity for EMA confirm the diagnosis of SS. Primitive neuroectodermal tumors will show positivity for CD99 and negativity for CD56, and malignant peripheral nerve sheath tumors will show negativity for CD99 and positivity for CD56 [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. Immunohistochemically, our case was completely positive for bcl-2, EMA, vimentin, and focally positive for CD99 and completely negative for WT-1, S-100, desmin, CD34, and CD117.…”

Section: Discussionmentioning

confidence: 99%

“…However, monophasic SS may be difficult to differentiate from other spindle cell sarcomas [3,4,5]. The differential diagnosis includes leiomyosarcoma, fibrosarcoma, malignant peripheral nerve sheath tumors, primitive neuroectodermal tumors, fibrous tumors, Wilms' tumors, hemangiopericytoma, congenital mesoblastic nephroma, and sarcomatoid renal cell cancer [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. …”

Section: Discussionmentioning

confidence: 99%

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Primary Synovial Sarcoma of the Kidney

Özkanli¹,

Yıldırım²,

Zemherı³

et al. 2013

Urol Int

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Synovial Sarcoma (SS) is a soft tissue neoplasm that occurs generally in the proximity of large joints. Here, we report a case of a 45-year-old man who was diagnosed with Primary SS of the kidney which is an extremely rare tumor that accounts for less than 2% of malignant renal tumors. We also review the literature on primary synovial sarcomas of the kidney and focus especially on the renal tumors' differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Primary Synovial Sarcoma of the Kidney

Özkanli¹,

Yıldırım²,

Zemherı³

et al. 2013

Urol Int

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“…They are not only rare tumors, but also difficult to differentiate pathologically from adult Wilms tumors, primary renal primitive neuroendocrine tumors, congenital mesoblastic nephromas, sarcomatoid renal cell carcinoma and undifferentiated carcinoma. An accurate diagnosis is important as these unique tumors require different treatment regimens (6).…”

Section: Introductionmentioning

confidence: 99%

A Case of Renal Synovial Sarcoma Treated with Adjuvant Ifosfamide and Doxorubicin

Özkan

Mertsoylu²,

Özardalı

2011

Intern. Med.

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Primary renal synovial sarcomas (SS) are rare tumors of the kidney. Faria et al first described primary renal synovial sarcoma in 1999 ( Mod Pathol 12:94A). In this paper we present a primary renal synovial sarcoma case and review the 41 primary renal synovial sarcoma cases reported to date. Primary renal synovial sarcomas can exist in either a monophasic or a biphasic pattern. The monophasic variant of primary renal synovial sarcoma is more common and tends to have a better prognosis than the biphasic variant. We present in this paper, a 68-year-old woman with primary renal synovial sarcoma. She presented with right flank pain and abdominal distention. Postoperative pathology of the 20 cm mass on magnetic resonance imaging showed histologic and immunochemical features of synovial sarcoma with coexisting spindle and epithelial cells. She underwent adjuvant ifosfamide and doxorubicin chemotherapy and was free of disease at 1 year after diagnosis. As a conclusion, physicians should be aware of the possibility of malignancy in cystic renal masses and that synovial sarcoma is one of the possibilities.

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Malignant Renal Tumors

Shehata

Naguib

Lin

et al. 2014

Pediatric Malignancies: Pathology and Imaging

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Renal tumors account for approximately 6-7 % of all pediatric cancers, with Wilms' tumor being the most common malignancy [ 1 , 2 ]. Current classifi cation and staging criteria for renal tumors, aided by advances in molecular and cytogenetic abnormalities, have allowed accurate diagnostic, staging, and therapeutic protocols [ 2 ], elucidated new categories of renal neoplasms, and created more inclusive classifi cation (Table 10.1 ) [ 2 , 3 ]. Overview of Imaging FeaturesThe imaging evaluation of a suspected pediatric renal mass should always begin with ultrasound. Sonography is readily available, can be performed without sedation and intravenous contrast, and does not expose the child to ionizing radiation. If a renal mass is identifi ed on ultrasound, further evaluation of the renal vessels and inferior vena cava (IVC) with both gray scale and color Doppler images are required to detect vascular extension, present in up to 10 % of cases [ 4 ]. Further evaluation with contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI) is also required for local staging of the mass prior to any intervention, as per the guidelines of the Children's Oncology Group (COG). Either modality can be used, depending on institutional availability and expertise [ 5 ].In keeping with the As Low As Reasonably Achievable (ALARA) principle regarding ionizing radiation exposure, pre-contrast and multiphase contrast enhanced CT images are not required for diagnosis or staging of pediatric renal tumors [ 6 ]. A single-phase study in the portal venous phase (approximately 50 s after contrast injection) suffi ciently stages a renal tumor and delineates relevant anatomy. Multiplanar CT reconstructions or multiplanar scanning with MRI can confi rm the renal origin of the mass and assess its relationship to vital structures such as the renal vessels. If a partial nephrectomy is being considered, multiphase images are helpful to determine the relationship of the mass to the renal vessels and collecting system. A CT of the chest is required in all malignant renal tumors to evaluate for potential lung metastasis. Wilm's Tumor Defi nitionWilms' tumor ( syn: nephroblastoma), a malignant neoplasm originating from nephrogenic blastemal cells, is the second most common malignant, solid extracranial tumor in children [ 1 , 7 , 8 ]. It is a traditional blastematous tumor, exhibiting various stages of embryonic development and multiple lines of differentiation. Clinical Features and EpidemiologyIn children ranging from 0 to 15 years of age, Wilms' tumor occurs in seven to ten cases per million annually (1 in 10,000 children) and accounts for approximately 95 % of renal tumors, and comprises 6-7 % of all pediatric tumors [ 7 , 9 , 10 ]. It is the fi fth most common pediatric tumor and the second most common intraabdominal tumor in children [ 11 ].

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Primary synovial sarcoma of the kidney

Cited by 33 publications

References 9 publications

Primary Synovial Sarcoma of the Kidney

Primary Synovial Sarcoma of the Kidney

A Case of Renal Synovial Sarcoma Treated with Adjuvant Ifosfamide and Doxorubicin

Malignant Renal Tumors

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