Primary synovial sarcoma of the mediastinum: a poor prognosis in a 14‐year‐old girl

Saad, Asma; Bouacida, I.; Radhia, Bechir Ben; Zribi, Hazem; Dridi, Amira; Marghli, A.

doi:10.1002/rcr2.811

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Of note, given that the component of the mediastinum is complex, containing numerous pluripotent mesenchymal cells and various anatomical structures, the differential diagnosis regarding mediastinal neoplasms must be taken into consideration, including malignant thymoma, malignant mesothelioma, teratoma, seminoma, and solitary fibroma. Generally, due to calcification, hemorrhage and necrosis, imaging of mediastinal SS shows a heterogeneous mass with heterogeneous enhancement (9). In magnetic resonance imaging (MRI), the mass shows moderate or slightly low signals on T1-weighted imaging and mixed signals dominated by high signals on T2-weighted imaging.…”

Section: Discussionmentioning

confidence: 99%

A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager

Liu,

Cui,

Zhou

et al. 2024

Front. Oncol.

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Synovial sarcomas (SSs) are a rare group of malignant tumors originating from pluripotential mesenchymal cells, which commonly occur as the primary tumor in the soft tissues near the articular surface, tendons, and articular synovium. Herein, we report a rare case of mediastinal SS in an 18-year-old teenager who initially presented with cough as the primary symptom. In this case, plain chest CT and contrast-enhanced CT clearly revealed the lesion presenting as a round-like and uneven density mass in the mediastinum with heterogeneous enhancement, which compressed the trachea and invaded the adjacent vessels. Based on the results of immunohistochemistry and fluorescence in situ hybridization (FISH), combined with the differential diagnosis with other types of tumors in the mediastinum on imaging, we were able to diagnose the tumor as an SS located in the mediastinum. Subsequent resection of the lesion coupled with chemotherapy and immunotherapy led to an improvement in the patient’s symptoms.

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Section: Discussionmentioning

confidence: 99%

A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager

Liu,

Cui,

Zhou

et al. 2024

Front. Oncol.

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Biphasic synovial sarcomas of the liver: a case report and literature review

et al. 2022

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Background Synovial sarcoma is a soft tissue sarcoma of temporarily unknown histologic origin with the ability for biphasic differentiation, occurring mostly in the vicinity of large joints of the extremities. Synovial sarcoma that originates in the liver is extremely rare. Only 7 cases have been reported in the domestic and international literature. Case presentation We report an 11-year-old female patient who underwent partial hepatectomy for a liver mass. Microscopically, she was diagnosed with hepatic biphasic synovial sarcoma. Cytogenetic examination revealed the fusion gene SS18-SSX1 (+), which confirmed the diagnosis. Conclusion Synovial sarcoma of the liver is a rare malignancy that is difficult to diagnose. Confirmation of diagnosis is based on histopathological assessment combined with immunohistochemical staining and, if necessary, cytogenetic aids.

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A Primary Mediastinal Monophasic Spindle-Cell Synovial Sarcoma with Superior Venacaval Obstruction

et al. 2022

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Primary mediastinal sarcoma is a rare tumour that usually presents with nonspecific symptoms such as hoarseness, dyspnoea, and chest pain. Superior vena cava (SVC) syndrome is an extremely uncommon complication that is caused by the compression, invasion, and thrombosis of the SVC or brachiocephalic veins. SVC syndrome can present as asymptomatic cases or as rare life-threatening emergencies with upper airway obstruction and increased intracranial pressure. This report describes the case of a 58-year-old female who presented with swelling of the face, neck, and upper limbs associated with dyspnoea on exertion. The radiological investigations revealed a large well-defined central necrotic peripherally enhancing lesion in the superior mediastinum extending anteriorly with the compression of brachiocephalic veins. A histopathological examination detected spindle cells arranged in fascicles with nuclear atypia with immunohistochemistry positive for creatine kinase (CK), smooth muscle actin (SMA), desmin and CD99. These findings established the diagnosis of a mediastinal monophasic synovial sarcoma with SVC obstruction. The patient was initiated on palliative radiotherapy for the management of the SVC, followed by systemic biological treatment with the tyrosine kinase inhibitor pazopanib, and was clinically improved. It is essential to promptly diagnose and treat this condition, especially when SVC syndrome manifests.

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Primary synovial sarcoma of the mediastinum: a poor prognosis in a 14‐year‐old girl

Cited by 3 publications

References 4 publications

A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager

A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager

Biphasic synovial sarcomas of the liver: a case report and literature review

A Primary Mediastinal Monophasic Spindle-Cell Synovial Sarcoma with Superior Venacaval Obstruction

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