Primary thymic carcinoma

Liu, Hung-Chang; Hsu, Wen Hu; Chen, Yu-Jen; Chan, Yu‐Jan; Wu, Yue; Huang, Bin; Huang, Mu-Shun

doi:10.1016/s0003-4975(01)03607-4

Cited by 108 publications

(97 citation statements)

References 24 publications

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“…Squamous cell carcinoma was the most common type of thymic carcinoma in this series followed by lymphoepithelioma -like carcinomas. Although there are reports in the literature [8,9] that SCC had a better prognosis than other histologic types of thymic carcinoma, our results did not show this tendency. Contrary to Blumberg and colleagues' [12] report, our data revealed that the prognosis of WD SCC was better than other types of thymic carcinoma.…”

Section: Commentcontrasting

confidence: 99%

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Thymic carcinoma: involvement of great vessels indicates poor prognosis

Tseng¹,

Wang²,

Wu³

et al. 2003

The Annals of Thoracic Surgery

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Background. Thymic carcinoma is a rare, indolent, and invasive cancer. This study investigated the treatment results of thymic carcinoma and clinical prognostic factors.Methods. From June 1988 to January 2002, 38 patients were enrolled in this study with the diagnosis of thymic carcinoma in the Cheng-Kung University Hospital based on Rosai's and Muller-Hermelink's classification. Clinical and pathologic data were retrospectively reviewed. Survival analysis was performed using the KaplanMeier, log rank, and Wilcoxon tests. Statistical significance was defined as p < 0.05.Results. Pathology revealed 14 poorly differentiated, 6 moderately differentiated, and 8 well-differentiated squamous cell carcinomas; 8 lymphoepithelioma-like carcinomas; and 2 other carcinomas. Pathologic staging using the Masaoka system included 6 stage II, 23 stage III, and 9 stage IV patients. Six biopsies, five debulkings,

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Section: Commentcontrasting

confidence: 99%

“…In our experience, only the patients undergoing complete resection of the tumor had long-term survival. Our cumulative survival result was almost the same as Blumberg and colleagues' [12] report, and was better than most serial reports [8,9,11]. This suggests that aggressive surgery must play a role in increasing survival rate.…”

Section: Commentsupporting

confidence: 83%

Thymic carcinoma: involvement of great vessels indicates poor prognosis

Tseng¹,

Wang²,

Wu³

et al. 2003

The Annals of Thoracic Surgery

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“…The expression of Kit was also used as a diagnostic tool of these tumors [39,93] [8,31,67]. Nine studies reported that the staging wasn't a relevant prognostic factor [6,9,19,20,30,46,57,71,74].…”

Section: Discussionmentioning

confidence: 99%

Review of the literature about Thymic Carcinomas

Mlika¹,

Mezni²

2017

Arch Pulmonol Respir Care

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Background: Thymic carcinomas (TC) are rare tumors with challenging diagnosis and management. We aimed to describe the clinical and microscopic characteristics of TC through a literature review.Results: 82 articles and abstracts were retained about 2913 TC. Our study contained 1760 men and 1153 women with a mean age of 55.32 years. The delay of diagnosis was specifi ed in 10 cases and varied between 8 months and 2 years. Symptoms consisted mainly in chest pain and dyspnea. The Computed Tomography-scan (CT-scan) fi ndings were specifi ed in 63 cases. Microscopic fi ndings were noticed in 1766 cases. They consisted mainly in squamous cell carcinoma in 1297 cases and undifferentiated carcinoma in 239 cases. The patients presented stage 1 tumors in 165 cases, stage II in 362 cases, stage III in 1011 cases and stage IV in 1166 cases. The treatment modalities were noticed in 2803 cases. There was no consensus of the regimen of chemotherapy or the place of the radiation therapy but all studies highlighted the key role of the complete surgical resection when possible. Conclusion:Our results highlight the lack of consensual management of TC. The chemotherapy regimen, the second-line chemotherapy and the indications of radiation therapy seem non-consensual and need further studies. Many interrogations remain concerning the management of these tumors according to their histologic grade. The real place of targeted therapy remains to assess and the rare opinions published are based on rare and non-representative cases.

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“…The outcome of patients with unresectable locally advanced or metastatic thymic carcinoma is poor. Even after conventionally fractionated definitive radiation therapy (with or without chemotherapy), median survival is 11-28 months [9][10][11] . Until recently, few data about the effect of sabr on thymic carcinoma have been available.…”

Section: Figurementioning

confidence: 99%

Stereotactic Ablative Radiotherapy with CyberKnife for Advanced Thymic Carcinoma: A Case Report

et al. 2015

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Thymic carcinoma is a rare but lethal mediastinal cancer. The optimal treatment for advanced thymic carcinoma is not yet established. This report is the first known of stereotactic ablative radiotherapy (sabr) with CyberKnife (Accuray, Sunnyvale, CA, U.S.A.) as definitive therapy for thymic carcinoma.The patient, a 70-year-old woman with thymic carcinoma, invasion into neighboring organs, and pleural metastases-underwent CyberKnife sabr at 40 Gy in 5 fractions for two lesions, one in the thymus and one in the right paraspinal pleura. After 61 months of observation, a partial response was observed in the irradiated fields. However, disease progression in the non-irradiated pleura was noted. The patient underwent salvage CyberKnife sabr for the four initially nonirradiated pleural lesions. Computed tomography images obtained 10 months after the salvage therapy revealed a partial response.The patient is living, with progression-free irradiated lesions and no radiation-related toxicity. CyberKnife sabr is feasible for patients who are unable to undergo either surgery or conventionally fractionated radiation therapy.

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Primary thymic carcinoma

Cited by 108 publications

References 24 publications

Thymic carcinoma: involvement of great vessels indicates poor prognosis

Thymic carcinoma: involvement of great vessels indicates poor prognosis

Review of the literature about Thymic Carcinomas

Stereotactic Ablative Radiotherapy with CyberKnife for Advanced Thymic Carcinoma: A Case Report

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