Primary thyroid diffuse large B-cell lymphoma coexistent with papillary thyroid carcinoma: A case report

Xie, Shuang; Liu, Wei; Xiang, Yuyan; Dai, Yinghuan; Ren, Jun

doi:10.1002/hed.23917

Cited by 16 publications

(19 citation statements)

References 20 publications

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“…5 Although the coexistence of PTL and PTC is rare, there have been a few previous reports. 6,7 The current patient had two independent malignant tumors each with unique characteristics, as confirmed by histological and pathological examinations and consistent with the diagnostic standards of primary cancers. We compared the clinical characteristics of the current and previously reported cases (Table 1).…”

Section: Discussionsupporting

confidence: 80%

Coexistence of primary thyroid diffuse large B cell lymphoma and papillary thyroid carcinoma: a case report and literature review

Chen

Liu

Dong³

2019

J Int Med Res

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Primary thyroid lymphoma (PTL) is a very rare type of thyroid malignant tumor. PTL coexisting with papillary thyroid carcinoma (PTC) is even scarcer and can be easily overlooked. We present our experience of the diagnosis and treatment of a 37-year-old woman with primary thyroid diffuse large B cell lymphoma complicated with PTC. We also considered this case in the context of previous reports. The results indicated that the incidence of concurrent Hashimoto’s disease varied among patients with different lymphoma subtypes, with the highest incidence in patients with mucosa-associated lymphoid tissue lymphoma. Furthermore, thyroid cancer and thus the combination of PTL and PTC were more common in women.

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Section: Discussionsupporting

confidence: 80%

Coexistence of primary thyroid diffuse large B cell lymphoma and papillary thyroid carcinoma: a case report and literature review

Chen

Liu

Dong³

2019

J Int Med Res

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“…The other 30% comprises mucosa associated lymphoid tissue (MALT) lymphomas, which are indolent in most cases and have a better response to systemic treatment (5,6). Some cases of association between HT and both PTC and MALT lymphomas have been described (7)(8)(9), while a DLBCL in the context of coexisting HT and PTC is very rare (10).…”

Section: Introductionmentioning

confidence: 99%

Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis

Trovato

Giuffrida

Seminara³

et al. 2017

Arch. Endocrinol. Metab.

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SUMMARYPapillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. On the contrary, primary thyroid lymphoma (PTL) is a rare disease, accounting for 2% to 5% of all thyroid malignancies. Despite several cases in which both PTC and PTL arise in the setting of Hashimoto's thyroiditis (HT), the coexistence of both tumors in HT patients is very rare. Herein we report the case of a 66-year-old woman with long-standing nodular HT under replacement therapy, who presented with a fast, painless enlargement in the right anterior side of the neck. Thyroid ultrasonography demonstrated increased growth of a hypoechoic nodule in the right lobe measuring 32 x 20 mm. A total thyroidectomy was performed, and histology revealed a diffuse large B-cell lymphoma (DLBCL) on a background of florid HT. Moreover, a unifocal papillary microcarcinoma, classical variant (7 mm, pT1aNxMx), was discovered. The patient was then treated with chemotherapy for the PTL, but she did not undergo radioactive iodine ablation treatment for the microPTC as per guidelines. Two years after surgery, the patient had no evidence of recurrence of either malignancy. This rare case highlights the importance of monitoring HT patients with nodular lesions, especially if they have long-standing disease. In addition, PTL should be considered for differential diagnosis in elder HT patients who present with sudden thyroid enlargement. Arch Endocrinol Metab. 2017;61(6):643-6

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“…The coexistence of both malignancies in the same patient has only rarely been reported. [ 1 2 3 4 5 6 7 8 9 10 ] Although there have been numerous reports of lymphoma involving the thyroid gland, there are only a few case reports of primary thyroid lymphoma (PTL) diagnosed by FNAB due to the diagnostic difficulty. Unfortunately, many of these cases were misdiagnosed on cytology.…”

Section: Discussionmentioning

confidence: 99%

“…Although the risk of papillary thyroid carcinoma (PTC) is higher in patients with lymphocytic thyroiditis, there have been very few reports of these malignancies coexisting in the same patient. [ 1 2 3 4 5 6 7 8 9 10 ] Here, we report a case of diffuse large B-cell lymphoma (DLBCL) of the thyroid coexisting with PTC in an elderly female patient diagnosed initially with high-grade non-Hodgkin's lymphoma (NHL). A differential diagnosis of lymphocytic thyroiditis was made using a fine-needle aspiration biopsy (FNAB) and was subsequently confirmed by histologic examination.…”

Section: Introductionmentioning

confidence: 99%

Cytodiagnosis of primary thyroid lymphoma coincident with unnoticed papillary thyroid carcinoma: A case report and review of the literature

Gozde

Sarbay

Özpek

2018

J Cytol

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Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, whereas primary thyroid lymphoma is very rare. Here, we report a case in which a right-sided nodule measuring 4.3 × 2.2 cm was examined using fine-needle aspiration biopsy. This revealed abundant monomorphic non-cohesive large lymphoid cells without thyroid follicular cells, on which basis acytodiagnosis of lymphoma coincident with lymphocytic thyroiditis was made. Subsequent histologic examination revealed CD45−, CD20+, and Bcl-6 + and cytokeratin-, CD3-, CD5-, and CD30-negative tumor cells arranged diffusely in the whole thyroid coexisting with a separate PTC nodule sized 1.3 × 1.0 cm in the right lobe. The key point exemplified by this case is that a cytodiagnosis of this extremely rare coexistence of PTC and lymphoma can be made by adequate sampling of both nodules preoperatively. In our case, only one nodule formation was sampled, and therefore the coexisting PTC was not detected with cytology preoperatively.

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Primary thyroid diffuse large B-cell lymphoma coexistent with papillary thyroid carcinoma: A case report

Abstract: This rare case highlights the importance for physicians to keep PTL in mind for differential diagnosis in patients with sudden thyroid enlargement and who have clinical history of Hashimoto thyroiditis.

Cited by 16 publications

References 20 publications

Coexistence of primary thyroid diffuse large B cell lymphoma and papillary thyroid carcinoma: a case report and literature review

Coexistence of primary thyroid diffuse large B cell lymphoma and papillary thyroid carcinoma: a case report and literature review

Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis

Cytodiagnosis of primary thyroid lymphoma coincident with unnoticed papillary thyroid carcinoma: A case report and review of the literature

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