Coexistence of primary thyroid diffuse large B cell lymphoma and papillary thyroid carcinoma: a case report and literature review

Chen, Ling; Liu, Yihui; Dong, Chao

doi:10.1177/0300060519869133

Cited by 9 publications

(10 citation statements)

References 16 publications

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“…A summary of these reports is shown in Table 3. [15][16][17][18][19][20][21][22][23][24][25] Consistent with previous findings, all the 8 patients in our study were female and had papillary thyroid cancers. The phenomenon that these DPM occurs more frequently in women may be related to the fact that thyroid cancer is more common in women than man.…”

Section: Discussionsupporting

confidence: 91%

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Synchronous double primary lymphoma and thyroid cancer

Zhu²,

Xiao³

et al. 2021

Medicine

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Synchronous double primary malignancies of lymphoma and thyroid cancer are rare. In this retrospective study, we investigated the pathology, clinical characteristics, and treatment outcomes of patients with synchronous lymphoma and thyroid cancer. Of the 1156 newly diagnosed lymphoma patients treated in our hospital between January 1, 2016 and February 1, 2021, 8 cases had lymphoma complicated with thyroid cancer. The clinical data and treatment strategies of 8 cases with synchronous lymphoma and thyroid cancer were retrospectively analyzed. The median age of patients was 56 (25–64) years. All the 8 patients were female and papillary thyroid cancer. Only 1 patient had peripheral T-cell lymphoma, and the other 7 were B-cell lymphoma. Seven of 8 patients had normal free triiodothyronine and free thyroxine at the time of diagnosis. Seven thyroid cancer patients received total thyroidectomy and levothyroxine and the remaining 1 patient has a plan for surgery. At the last follow-up, 7 patients with B-cell lymphoma are alive; the patient with peripheral T-cell lymphoma complicated with thyroid cancer died due to lymphoma progression. Synchronous lymphoma and thyroid cancer are more predominant in women. Histologically, B-cell lymphomas and papillary thyroid cancer subtypes are more common. Attention should be paid to the presence of thyroid nodules in the diagnosis of lymphoma. Biopsy or ultrasound-guided fine needle aspiration of the suspicious thyroid nodule should be performed to exclude thyroid malignancy.

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Section: Discussionsupporting

confidence: 91%

“…To our knowledge, rarely has any study to date investigated the association between synchronous thyroid cancer and lymphoma, most of previous reports are case reports. A summary of these reports is shown in Table 3 [15–25] . Consistent with previous findings, all the 8 patients in our study were female and had papillary thyroid cancers.…”

Section: Discussionsupporting

confidence: 88%

Synchronous double primary lymphoma and thyroid cancer

Zhu²,

Xiao³

et al. 2021

Medicine

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“…A study published by Ling Chen et al stated that Hashimoto's thyroiditis was present in 81.25% of patients, which included all patients with mucosa-associated lymphoid tissue (MALT) lymphoma. The study also stated that the incidence of Hashimoto's thyroiditis differed significantly among the four lymphoma groups: MALT, DLBL, MALT + DLBL, and small lymphocytic lymphoma (P=0.014) (11). Although most cases have Hashimoto's thyroiditis in the background, it has been reported that MALT lymphoma can also develop as de novo without the presence of the former (12).…”

Section: Discussionmentioning

confidence: 83%

“…The diagnosis of extranodal marginal zone lymphoma may be delayed due to poor systemic symptoms. The occurrence of B symptoms and cytopenia is very rare in this disease (11,12). Hematological tests along with few additional tests are required for patients with MALT lymphoma that are standard for patients with NHL required at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of Primary Mucosa-Associated Lymphoid Tissue Lymphoma of Thyroid and Papillary Thyroid Microcarcinoma in a Background of Hashimoto’s Thyroiditis

DÜGER¹,

Çalapkulu²,

UÇAN³

et al. 2020

Turk J Endocrinol Metab

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Papillary thyroid carcinoma (PTC) is the most common endocrine cancer; however, extranodal marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) of the thyroid gland is quite rare. The comorbid condition of both cancers is an infrequent event. In the present study, we report a 65-year-old woman, who underwent a thyroid ultrasound examination due to palpable thyroid nodules. The reports of the thyroid ultrasound revealed thyroiditis and the presence of multiple nodules on both lobes. Although the results revealed that biopsies were benign, total thyroidectomy was performed due to the presence of multiple nodules that may become difficult for the subsequent follow-up. Histopathological analysis exhibited the presence of papillary thyroid microcarcinomas in two foci, Hashimoto's thyroiditis accompanied with MALT lymphoma. No metastasis was found in postoperative computed tomography scans. However, bone marrow biopsy indicated uniform marginal zone lymphoma. From the result, it can be concluded that PTC and primary thyroid lymphoma may be associated with Hashimoto's thyroiditis, and for both the diseases multimodal approach is required.

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“…The onset of PTL from HT, which is rare, usually follows a chronic transformation over many years; however, some cases have been reported in literature to occur within 18 months after the diagnosis of HT [47]. The occurrence of double malignancies, papillary thyroid carcinoma (PTC), and PTL in HT patients is ever rarer, and in literature, only few cases have been reported in the world so far-from China [48][49][50], Italy [51], Korea [52], and Peru [53].…”

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confidence: 99%

The Risk of Developing Lymphoma among Autoimmune Thyroid Disorder Patients: A Cross-Section Study

et al. 2022

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Background. Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are the most common types of autoimmune thyroid diseases (AITD), and both are characterized by the infiltration of lymphocytes into the thyroid gland. Moreover, autoimmune diseases like HT have a higher risk of developing lymphoma. This study is aimed at assessing the prevalence and association of lymphoma in patients with AITD. Methods. This cross-sectional study was conducted in King Abdulaziz Medical City, Jeddah, Saudi Arabia. Data were gathered from the medical records of patients aged 18 years or older who developed AITD. A total number of 140 medical records were collected, and 72 patients were included after applying in exclusion criteria. Data on the subtype, clinical-stage, treatment modality, patient status, remission, and relapse were collected for patients who developed lymphoma. Results. Among 72 patients who developed AITD, HT was diagnosed in 58 (80.6%) patients and GD in 14 (19.4%). Five (7%) patients were diagnosed with lymphoma all of whom had a history of HT. The subtypes of lymphoma were diffuse large B-cell lymphoma (DLBCL 3; 4.2%), follicular lymphoma 1 (1.4%), and Hodgkin’s lymphoma 1 (1.4%). Conclusion. The prevalence of PTL in patients with AITD, specifically HT, was 7%. Most patients developed NHL, with DLBCL being the most common subtype. The onset of lymphoma in this study was lower than reported in the literature. All patients with PTL had HT in their backgrounds. Further national studies are warranted to explore the relationship between the two diseases to provide more insight into the comprehension of this association.

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Coexistence of primary thyroid diffuse large B cell lymphoma and papillary thyroid carcinoma: a case report and literature review

Cited by 9 publications

References 16 publications

Synchronous double primary lymphoma and thyroid cancer

Synchronous double primary lymphoma and thyroid cancer

Coexistence of Primary Mucosa-Associated Lymphoid Tissue Lymphoma of Thyroid and Papillary Thyroid Microcarcinoma in a Background of Hashimoto’s Thyroiditis

The Risk of Developing Lymphoma among Autoimmune Thyroid Disorder Patients: A Cross-Section Study

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