Primary Treatment and Prognostic Factors of Carcinosarcoma of the Ovary, Fallopian Tube, and Peritoneum

Lu, Chien-Hsing; Chen, I-Hui; Chen, Yi Jen; Wang, Kung-Liahng; Qiu, Jian Tai; Lin, Hao; Lin, Wu-Chou; Liou, William W.; Huang, Yu-Fang; Lin, Yu Tzu; Tee, Yi-Torng; Hung, Yao-Ching

doi:10.1097/igc.0000000000000083

Cited by 20 publications

(14 citation statements)

References 23 publications

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“…[98][99][100] However, in view of the paucity of studies, the ICCR recommends that it would be useful to record the percentage of the epithelial and mesenchymal elements as well as the subtypes of the epithelial and mesenchymal components. However, the panel recognises that on occasions it may be difficult or even impossible to classify the epithelial and mesenchymal subtypes given that overlapping and mixed patterns not infrequently occur in this tumour type.…”

Section: Carcinosarcoma Subtypesmentioning

confidence: 99%

“…This is a recommended rather than a required element and collection of these data may be informative for the future regarding the prognosis and management of these neoplasms. [98][99][100] Tumour grade Mucinous carcinoma. There is also little evidence for grading mucinous carcinomas, although oncologists often ask for a tumour grade.…”

Section: Carcinosarcoma Subtypesmentioning

confidence: 99%

See 1 more Smart Citation

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

et al. 2015

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Section: Carcinosarcoma Subtypesmentioning

confidence: 99%

Section: Carcinosarcoma Subtypesmentioning

confidence: 99%

Data set for reporting of ovary, fallopian tube and primary peritoneal carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

et al. 2015

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“…Some reviews have been published on the primary treatment and prognostic factors of Müllerian carcinosarcomas ( 9 , 10 ). Based on these reviews, platinum-based chemotherapy is the mainstay of adjuvant systemic treatment, and the addition of paclitaxel or ifosfamide to platinum is recommended as first-line treatment.…”

Section: Discussionmentioning

confidence: 99%

Primary peritoneal carcinosarcoma arising from the Douglas pouch: A case report

Koyanagi

Ando

et al. 2018

mol clin onc

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Primary peritoneal carcinosarcoma is extremely rare and only few cases have been reported in the literature to date. We herein present a case of carcinosarcoma of the Douglas pouch in a 73-year-old Japanese woman. The patient complained of fever and lower abdominal pain, and a large pelvic mass (>10 cm in diameter) was detected, with rectal invasion. Laparotomy was performed and revealed a left ovarian abscess and a Douglas pouch mass; however, there was no obvious tumor involvement of the bilateral ovaries or uterus. The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and tumor debulking, with a reduction rate of ~30%. Sigmoid colostomy was also performed due to the deep and wide rectal invasion. Histologically, the tumor was composed of a mixture of ovarian high-grade serous carcinoma and spindle-cell sarcoma mimicking leiomyosarcoma. Immunohistochemically, the serous carcinoma component was positive for cytokeratin (CK)7, Wilms' tumor-1 and p53 (null type), while CDX-2 and CK20 were negative. The spindle-cell sarcoma component was positive for vimentin and α-smooth muscle actin. The present case was diagnosed as carcinosarcoma of the homologous type derived from the peritoneum in the Douglas pouch. The patient received several courses of combination chemotherapy with paclitaxel, carboplatin and bevacizumab, and achieved complete remission. The principal treatment for such cases is surgery, and several chemotherapeutic regimens, including paclitaxel and carboplatin, or cisplatin and ifosfamide, have been reported. The accumulation of more clinical cases is crucial for understanding the clinicopathological characteristics of these rare tumors and establishing effective therapeutic strategies.

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“…Bilateral ovarian tumours and metastatic tumours larger than 2cms were significantly associated with a poorer overall survival. 8 Regarding our case, the factors which contributed for the good prognosis were early stage disease, unilateral ovarian tumour, no pelvic lymph node metastasis, omentectomy, no residual implants after surgery and platinum based treatment.…”

Section: Discussionmentioning

confidence: 99%