Primary tumor of thoracic vertebra: chondrosarcoma

Keskin, Fatıh; Kalkan, Havva; Kaciran, Burkay K.; Erdi, Mehmet Fatih; Karataş, Yaşar; Kalkan, Erdal

doi:10.1016/j.spinee.2015.08.054

Cited by 2 publications

(1 citation statement)

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“…Chondrosarcomas typically occur in adults, and when located posteriorly in the chest, they may invade spinal nerves leading to neurological symptoms and pain. Surgery is the mainstay of treatment and prognosis is influenced by tumour size, grade and location [119].…”

Section: Cartilage Tumoursmentioning

confidence: 99%

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Ghigna

Montpréville

2021

Eur Respir Rev

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The diagnosis of a mediastinal mass may be challenging for clinicians, since lesions arising within the mediastinum include a variety of disease entities, frequently requiring a multidisciplinary approach. Age and sex represent important information, which need to be integrated with imaging and laboratory findings. In addition, the location of the mediastinal lesion is fundamental; indeed, we propose to illustrate mediastinal diseases based on the compartment of origin. We consider that this structured approach may serve as hint to the diagnostic modalities and management of mediastinal diseases. In this review, we present primary mediastinal tumours in the evolving context of new diagnostic and therapeutic tools, with recently described entities, based on our own experience with >900 cases encountered in the past 10 years.

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Section: Cartilage Tumoursmentioning

confidence: 99%

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Ghigna

Montpréville

2021

Eur Respir Rev

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TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma

Tang

Guo

et al. 2016

Tumor Biol.

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The present study demonstrated that T cell factor 1 (TCF-1) protein, a component of the canonical Wnt/β-catenin signaling pathway, can regulate the expression of runt-related transcription factor 2 (runx2) gene and Sry-related HMG box 9 (sox9) gene, which may participate in the differentiation of chondrosarcoma. Dedifferentiated chondrosarcoma (DDCS) is a special variant of conventional chondrosarcoma (CCS), associated with poor survival and high metastasis rate. However, little is known about the mechanism of its occurrence; thus, no effective treatment is available except surgery. Earlier, high expression of runx2 and low expression of sox9 were found in DDCS compared with CCS. Using Western blot to detect clinical tissue samples (including 8 CCS samples and 8 DDCS samples) and immunohistochemistry to detect 85 different-grade chondrosarcoma specimens, a high expression of TCF-1 in DDCS tissues was found compared with CCS tissues. This difference in expression was related to patients’ prognosis. Results of luciferase, chromatin immunoprecipitation, and gel electrophoresis mobility shift assays demonstrated that TCF-1 protein could bind to the promoter of runx2 gene directly and sox9 gene indirectly. Hence, it could regulate expression of runx2 gene positively and sox9 gene negatively. Furthermore, in vitro and in vivo experiments showed that TCF-1 protein was closely related to the phenotype and aggressiveness of chondrosarcoma. In conclusion, this study proved that TCF-1 participates in the dedifferentiation of DDCS, which may be mediated by runx2 gene and sox9 gene. Also, TCF-1 can be of important prognostic value and a promising therapeutic target for DDCS patients.

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Primary tumor of thoracic vertebra: chondrosarcoma

Cited by 2 publications

References 0 publications

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

Mediastinal tumours and pseudo-tumours: a comprehensive review with emphasis on multidisciplinary approach

TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma

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