Primary urethral transitional cell carcinoma with scrotal metastases

Perera, ND

doi:10.4038/cmj.v47i3.3439

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Lookingbill et al ., in a study of 4020 patients with cancer, found the overall incidence of cutaneous metastasis to be about 10%; however, they identified only one patient who developed cutaneous metastasis to the scrotum (incidence of 0.02%). We were able to identify 29 men who developed cutaneous metastasis to the scrotum from an internal malignancy …”

Section: Scrotal Metastasesmentioning

confidence: 99%

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Cutaneous scrotal metastasis: origins and clinical characteristics of visceral malignancies that metastasize to the scrotum

Hoyt¹,

Cohen²

2013

Int J Dermatology

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Cutaneous metastases occur in about 10% of patients with cancer, occasionally presenting as the initial sign of internal malignancy. Most often cutaneous metastases are an indicator of advanced cancer and are associated with a poor prognosis. The scrotum is a rare site of cutaneous metastasis, and metastatic tumor to the scrotum can be mistaken for other skin lesions. We reviewed the published literature regarding patients who developed cutaneous metastasis to the scrotum. We summarized the clinical characteristics of these men, including primary tumor sites, age at diagnosis, treatment regimens, interval between diagnosis of primary tumor and subsequent metastasis, and outcomes. We extensively searched the PubMed medical database for papers on visceral malignancies with metastasis to the scrotum. We limited our definition to solid organ tumors; thus lymphomas, sarcomas, and melanomas of the scrotum were excluded. We identified 29 patients who developed scrotal metastases from visceral cancers. The colon/rectum (34%), prostate (28%), and lung (14%) were the most frequent sites of tumor origin. The prognosis for these patients is poor: mean patient survival was only four months after diagnosis of metastatic skin lesions. Cutaneous metastasis to the scrotum is a rare manifestation of internal malignancies that most often represents an advanced and/or progressive cancer associated with a poor prognosis. Treatment is often unsuccessful, and the mean patient survival following scrotal metastasis is <4 months.

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Section: Scrotal Metastasesmentioning

confidence: 99%

“…Rarely, solid organ tumors may metastasize to the scrotum. To our knowledge, cutaneous metastasis of visceral cancers to the scrotum has been described in 29 men . We review the embryology and anatomy of the scrotum and discuss characteristics of patients who developed cutaneous metastasis to the scrotum.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous scrotal metastasis: origins and clinical characteristics of visceral malignancies that metastasize to the scrotum

Hoyt¹,

Cohen²

2013

Int J Dermatology

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“…A review of the literature could only identify sporadic cases of paratesticular metastasis, the primaries being from malignant melanoma, anal carcinoma, renal cell carcinoma [7] , transitional cell carcinoma [8,9] , gastric and colorectal carcinoma [10–12] , desmoplastic small cell tumor [13] , signet ring cell carcinoma [14] , adenocarcinoma of prostate [15] . Among those we found only four cases of primary lung carcinoma: two presented as painful scrotal wall thickening (carcinoma en Cuirasse) [16,17] , the third one was described as a left scrotal mass in the inner layers of the scrotal wall, separate from the left testicle, epididymis and spermatic cord [18] , the fourth case was a metastatic scrotal tumor from a lung adenocarcinoma with a micropapillary component [19] .…”

Section: Discussionmentioning

confidence: 99%

Scrotal wall metastasis from a primary lung adenocarcinoma

Coussa-Koniski

Maalouf

Raad

et al. 2015

Respiratory Medicine Case Reports

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This a case of a 77 years old male heavy smoker, known to have Combined Pulmonary Fibrosis and Emphysema complicated by a primary invasive adenocarcinoma of the lung with bone metastasis, who presented with a two weeks history of right inguino-scrotal pain and swelling.Imaging studies revealed a right paratesticular formation that appeared to involve the epididymis and the scrotal wall.A biopsy of the mass showed morphological and Immunophenotypic features in favor of metastasis of an adenocarcinoma of the lung.Based on our literature review, there are only few published cases about scrotal wall metastasis of a lung primary.

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“…Renal cell carcinoma, 3 transitional cell carcinoma, 4,5 gastric carcinoma, 6 adenocarcinoma of prostate, 7 desmoplastic small cell tumour, 8 colorectal carcinoma 9 and signet ring cell carcinoma 10 are some of the other malignancies with reported metastases to the scrotal wall. Metastatic disease should always be suspected in scrotal swellings which are atypical in presentation and refractory to treatment.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma En Cuirasse of Scrotum–-Metastatic Malignancy from a Lung Primary

Rajasundaram

Montague

Lupton

2009

Cancer�Growth�Metastasis

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A 69 year old male who presented with painful, swollen and infl amed scrotum is presented as a unique case report. He was initially treated as a case of infection and was subject to further investigation due to poor response to antibiotics. CT scan showed thickened scrotal wall and an incision biopsy revealed metastatic 'carcinoma en cuirasse' of the scrotal wall with the primary foci in the lung. There has been one other such case reported in literature, presenting as generalised swelling of scrotum with the whole of the scrotal wall being involved.

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Primary urethral transitional cell carcinoma with scrotal metastases

Cited by 3 publications

References 5 publications

Cutaneous scrotal metastasis: origins and clinical characteristics of visceral malignancies that metastasize to the scrotum

Cutaneous scrotal metastasis: origins and clinical characteristics of visceral malignancies that metastasize to the scrotum

Scrotal wall metastasis from a primary lung adenocarcinoma

Carcinoma En Cuirasse of Scrotum–-Metastatic Malignancy from a Lung Primary

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