Primary vaginal cancer: role of MRI in diagnosis, staging and treatment

Gardner, Carly S.; Jalan, Sunil; Klopp, Ann H.; Devine, Catherine; Sagebiel, Tara; Viswanathan, Chitra; Bhosale, Priya

doi:10.1259/bjr.20150033

Cited by 59 publications

(60 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is thus recommended that women diagnosed with primary vaginal cancer are referred to a tertiary unit whenever possible. Accordingly, outcomes are influenced by the experience of the medical team in treating this type of rare tumor …”

Section: Management Of Invasive Cancer Of the Vaginamentioning

confidence: 99%

“…As extrapolated from cervical cancer, MRI is more sensitive in detecting tumor size, as well as paravaginal or parametrial involvement . In primary vaginal tumors, clinical assessment may be difficult and MRI may be a useful tool in individual cases owing to its superior soft tissue resolution …”

Section: Role Of Imaging Techniques In Diagnosis Staging and Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Cancer of the vagina

Adams

Cuello

2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Diagnosis of a primary vaginal cancer is rare because most of these lesions will be metastatic from another primary site. Although cancer of the vagina is more common in postmenopausal women, an increase in young women being diagnosed with primary vaginal cancer has been reported, especially in countries with a high HIV prevalence. This will be associated with persistence of high‐risk HPV infection. The emphasis should be on primary prevention with prophylactic HPV vaccination. Once there is a suspicion of a primary vaginal cancer, this should be confirmed histologically with biopsy. Staging has been done clinically, similar to cervical cancer; however, there is a role for imaging in assisting with staging as this is often a difficult assessment. Treatment should be individualized and depends on stage as well as histologic subtype. It is prudent to refer cases to centers of excellence with experience in dealing with this rare gynecological cancer.

show abstract

Section: Management Of Invasive Cancer Of the Vaginamentioning

confidence: 99%

Section: Role Of Imaging Techniques In Diagnosis Staging and Treatmentmentioning

confidence: 99%

Cancer of the vagina

Adams

Cuello

2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…For ovarian cancer mucinous cystadenocarcinoma was observed in 14 cases (53.846%) and serous cystadenocarcinoma in 5 cases (19.2%) which has not come in accordance with Matz et al [8]. For vaginal and vulvar cancers, Squamous cell carcinoma was recorded as 2 cases (100%) in concordance with N. Murakami et al and CS Gardner et al [13,14]. For endometrium cancer, Adenocarcinoma was in 7 cases (70%) which is in accordance with Chen et al [11].…”

Section: Discussionmentioning

confidence: 52%

“…Complex hyperplasia represents a proliferative lesion with severe glandular complexity and crowding [11,12]. The incidence of primary vaginal cancer increases with age [13]. The precursors for vaginal cancer, vaginal intraepithelial neoplasia (VAIN) and invasive vaginal cancer, have a strong association with HPV infection and previous history of cervical neoplasia.…”

Section: Introductionmentioning

confidence: 99%

Elucidative Histopathological Study in Female Cancer Patients

Tarannum¹,

Manaswini²,

Ch³

et al. 2020

eijs

View full text Add to dashboard Cite

Aims: Because of the high incidence of cancer in females, we need to identify an accurate therapy to deal with the treatment of different types and stages of cancer. Histopathology acts as an important step to foresee the stage in which the cancer is present, its risk of metastasis, and the health outcomes after completion of treatment. Histopathology grading acts as an important criterion to determine the treatment pattern to be adopted, the prognosis in patients and other possible future risks. Hence conducting novel histopathologcial studies in major female cancers is necessary in determining the treatment plan to be chosen for the patient. Study design: Retrospective Observational study Place and Duration of Study: St. Ann’s Cancer Hospital, Warangal, Telangana, India. The patient’s histopathological reports were collected between March and August 2018. Methodology: The study sample included 275 non-pregnant female patients aged above 20 years and diagnosed with different cancers based on histopathology. Histopathological observations were taken by collecting parameters that included specimen submitted, lymphadenopathy specimen, macroscopic appearance, macroscopic tumour site, coexistent pathology, histological tumour grade, lymphovascular invasion, and distant metastasis.Results: The histopathologcial study concludes that regional lymph nodes (55.2%) were more common than other lymph nodes. Mostly, tumours demonstrated swollen and ulcerative appearance (48%), with grading as G0 stage (57.45%) having better prognosis and good quality of life. The most commonly observed types of tumours were as follows; In Breast Cancer: infiltrating ducal carcinoma (61. 9%), in Cervix Cancer: squamous cell carcinoma (83.92%), in Ovarian Cancer: mucinous cystadenocarcinoma (53.84%), in Vaginal Cancer, and in Vulvar Cancer: squamous cell carcinoma (100%).Conclusion: Knowing the type of tumour to develop, the threat it poses to health, and the mechanisms that mediate its development are important factors in the management of the disease. This detailed information may aid the implementation of more accurate preventive measures in a population by selecting the proper treatment plan and understanding the risk of future chances of reoccurrence and metastasis.

show abstract

“…Vaginal tumors are generally best seen on T2 imaging. 9 Despite the fact that the majority of available evidence is for squamous cell carcinoma and adenocarcinoma, the positron emission tomographycomputed tomography (PET-CT) value appears to be useful to address metastization, mainly in advanced stages. 10,11 The guided biopsy performed may have a role in cancer dissemination, but this appear to be very unlikely.…”

Section: Discussionmentioning

confidence: 99%

When an Unexpected Diagnosis Occurs: a Vaginal Premenopausal Sarcoma

Marcos-Figueiredo

Moreira

Morim³

et al. 2018

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

Vaginal cancer is a rare entity. The evidence on its management resides mostly in clinical cases or small case series. Of the histological types, the most frequent is the squamous cell carcinoma, followed by adenocarcinoma. But what to do when identifying an even more infrequent sarcoma in a premenopausal woman? In this study, we describe the case of a 53-year-old woman presenting with metrorrhagia for two months, who was evaluated after an intense episode. A necrotic and ulcerative vaginal swelling was documented and then submitted to biopsy, which revealed a vaginal sarcoma. The patient was referred to radiation therapy with 50 Gy (aiming to control the symptoms and to cause tumor reduction for posterior pelvic exenteration with intraoperative radiotherapy) and developed an extra-pelvic metastization at the end of the treatment, which caused a fast negative outcome. Despite the initial poor prognosis, a chemo-irradiation or primary surgery regimen might have achieved (although with greater side effects) a better survival. This case-report entails a discussion about the strategies to manage vaginal sarcoma in advanced stage and in premenopausal women. Palabras ClaveResumo O cancro vaginal é uma doença rara. A evidência para a sua abordagem reside fundamentalmente em casos clínicos ou pequenas séries de casos. Dentre os tipos de cancro histológicos, o mais frequente é o carcinoma espinocelular, seguido do adenocarcinoma. Mas o que fazer em presença de um sarcoma ainda mais raro numa mulher pré-menopáusica? No presente estudo, descrevemos o caso de uma mulher de 53 anos apresentando metrorragia por dois meses, avaliada após um episódio intenso. Foi então documentada uma tumefacção vaginal necrótica e ulcerativa, submetida a biópsia, que revelou um sarcoma vaginal. A paciente foi encaminhada para radioterapia

show abstract

Primary vaginal cancer: role of MRI in diagnosis, staging and treatment

Cited by 59 publications

References 78 publications

Cancer of the vagina

Cancer of the vagina

Elucidative Histopathological Study in Female Cancer Patients

When an Unexpected Diagnosis Occurs: a Vaginal Premenopausal Sarcoma

Contact Info

Product

Resources

About