Primary Vesicoureteral Reflux: Experimental Studies of its Etiology

Tanagho, Emil A.; Hutch, John A.; Meyers, Frederick H.; Rambo, Oscar N.

doi:10.1016/s0022-5347(17)63742-x

Cited by 134 publications

(43 citation statements)

References 7 publications

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“…An experimental study in dogs has con®rmed VUR after unilateral sympathectomy. 8 However it is unlikely that the sympathetic nerves themselves actively control VUR. 9 No development of VUR after sympathectomy has been reported.…”

Section: Discussionmentioning

confidence: 99%

Vesicoureteral reflux in the early stage of spinal cord injury: a retrospective study

Suzuki

Ushiyama

2001

Spinal Cord

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Study design: A retrospective study. Objectives: To investigate the risk factors of vesicoureteral re¯ux in the early stage of spinal cord injury. Setting: Japan. Methods: Urological evaluation, including cystography and urodynamic study was performed in patients in the early stage of spinal cord injury. The patients were divided into two groups. Group 1 included 13 patients with vesicoureteral re¯ux. Group 2 included 97 patients without vesicoureteral re¯ux. We compared Group 1 and Group 2 regarding bladder deformation, the level of spinal cord injury, bladder behaviour, bladder compliance, high urethral closure pressure and method of urine evacuation. Results: The patients injured between Th10 and L2 showed a signi®cantly higher incidence of vesicoureteral re¯ux than those injured in other areas (P50.01). Furthermore, bladder compliance among patients with vesicoureteral re¯ux tended to be low. Other factors showed no di erences between patients with and without vesicoureteral re¯ux.

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Section: Discussionmentioning

confidence: 99%

Vesicoureteral reflux in the early stage of spinal cord injury: a retrospective study

Suzuki

Ushiyama

2001

Spinal Cord

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“…The persistence of this membrane may be an intrinsic epithelial defect which causes a so-called stenotic ureterocele. Others have suggested a mesenchymal defect as the primary defect in ureteroceles [Weiss, 1988] because abnormal differentiation of muscle fibers had been observed with various techniques [Tanagho et al, 1965;Tokunaka et al, 1981]. Again, others have stressed pathologic innervation as the prime pathogenetic factor [Friedrich et al, 1987].…”

Section: Discussionmentioning

confidence: 99%

Hypoplastic thymus and T-cell reduction in EECUT syndrome

et al. 1997

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We report on a patient with EEC/EECUT syndrome and concomitant hypoplasia of the thymus and reduction of T cells in secondary lymphatic organs. The patient was born prematurely at 35 weeks of gestational age and exhibited ectodermal dysplasia, ectrodactyly, cleft palate and urinary tract abnormalities. On the left side, a large ureterocele was present. On the right side, an atretic ureter was found. Both conditions had led to intrauterine hydronephrosis, renal dysplasia, oligohydramnios, pulmonary hypoplasia, and death of the child. Ureteral malformations are thought to be of epithelial origin. Autopsy showed only small rudiments of thymic tissue containing single epithelial cells, but were completely devoid of Hassall corpuscules. Again, this clearly points to an ectodermal defect. Although there was severe reduction of T cells in secondary lymphatic organs, the thymic defect would not have necessarily led to immunological deficiency; perhaps this is the reason that an epithelial defect in the thymus of patients with EEC syndrome has not yet been reported. With regard to an updating of the diagnosis of the EEC/EECUT syndrome, an "EEC/EECUT plus" syndrome is suggested.

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“…In fact. Tanagho et al [1965] showed that disruption of the tri gone (in dogs) causes VUR. In this sequence of ideas, according to Weiss and Biancani [1983], the UVJ at high pressure could be related to a myogenic or a neurohumoral mechanism producing trigone tension.…”

Section: Discussionmentioning

confidence: 99%

Pressure Evaluation of the Antireflux Ability of the Rat Ureterovesical Junction

Vercesi

Constantinou

1986

Urol Int

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The bladder pressure necessary to cause vesicoureteral reflux (VUR) was measured in 16 female rats. Under general anesthesia, the ureters were exposed via an abdominal incission and a pressure catheter was placed near the ureterovesical junction. Values of bladder distension and bladder pressure increase to cause VUR were obtained by injecting isotonic saline in one ureter until VUR in the opposite ureter was detected as a sudden pressure increase. After 5 min the same procedure was done on the contralateral side. This procedure was repeated eight times in each rat with a 15-min intermission. The bladder pressure at which VUR occurred was measured through a uretral catheter. Two groups were studied: G1, control, and G2, administration of intravenous metoclopramide (0.007 mg/l00 g body weight) four times.

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Primary Vesicoureteral Reflux: Experimental Studies of its Etiology

Cited by 134 publications

References 7 publications

Vesicoureteral reflux in the early stage of spinal cord injury: a retrospective study

Vesicoureteral reflux in the early stage of spinal cord injury: a retrospective study

Hypoplastic thymus and T-cell reduction in EECUT syndrome

Pressure Evaluation of the Antireflux Ability of the Rat Ureterovesical Junction

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