2021
DOI: 10.1186/s12866-021-02254-7
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Priming with intranasal lactobacilli prevents Pseudomonas aeruginosa acute pneumonia in mice

Abstract: Background Increasing resistance to antibiotics of Pseudomonas aeruginosa leads to therapeutic deadlock and alternative therapies are needed. We aimed to evaluate the effects of Lactobacillus clinical isolates in vivo, through intranasal administration on a murine model of Pseudomonas aeruginosa pneumonia. Results We screened in vitro 50 pulmonary clinical isolates of Lactobacillus for their ability to decrease the synthesis of two QS dependent-vir… Show more

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Cited by 23 publications
(20 citation statements)
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“…The preventive approach may provide a microbiological barrier to hinder lung colonization by pathogenic bacteria through exclusion or competition mechanisms (Figure 1). In line with this view, priming with intranasal administration of lactobacilli has been demonstrated to prevent P. aeruginosa acute pneumonia in mice [65], while preventive treatments with S. salivarius and S. oralis have proved its efficacy in reducing recurrent otitis media in children [67][68][69]. On the other hand, a therapeutic approach carried out during or after antibiotic therapy could take advantage of the antibiotic-mediated reduction in the pathogenic load and consequent increase in the availability of adhesion sites in the lung while contributing to the repopulation of the pulmonary ecosystem with beneficial bacteria.…”
Section: Timing Of the Interventionmentioning
confidence: 75%
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“…The preventive approach may provide a microbiological barrier to hinder lung colonization by pathogenic bacteria through exclusion or competition mechanisms (Figure 1). In line with this view, priming with intranasal administration of lactobacilli has been demonstrated to prevent P. aeruginosa acute pneumonia in mice [65], while preventive treatments with S. salivarius and S. oralis have proved its efficacy in reducing recurrent otitis media in children [67][68][69]. On the other hand, a therapeutic approach carried out during or after antibiotic therapy could take advantage of the antibiotic-mediated reduction in the pathogenic load and consequent increase in the availability of adhesion sites in the lung while contributing to the repopulation of the pulmonary ecosystem with beneficial bacteria.…”
Section: Timing Of the Interventionmentioning
confidence: 75%
“…The lactobacilli strains also differed for their growth ability and acidification properties in artificial saliva [74]. As reported above, high degree of variability in the antivirulence potential against P. aeruginosa was also reported among Lactobacillus strains isolated from CF respiratory samples [65]. In another study, 57 Lactobacillus strains isolated from milk and yogurt samples were tested for their ability to inhibit the growth and biofilm formation of 80 P. aeruginosa strains [75].…”
Section: Open Questions For Respiratory Delivery Of Probiotics In Cf ...mentioning
confidence: 88%
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