Primiparity at Very Advanced Maternal Age (≥45 years)

Glasser, Saralee; Segev-Zahav, Aliza; Fortinsky, Paige; Gedal-Beer, Debby; Schiff, Eyal; Lerner‐Geva, Liat

doi:10.1016/j.fertnstert.2011.02.031

Cited by 29 publications

(39 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well established that women of very advanced maternal age (¸45 years) are at increased risk of both maternal and neonatal complications [8,9,19,20]. Most of the outcome data, however, pertain to assisted conceptions and pregnancies resulting from spontaneous conceptions have been largely understudied in this age group.…”

Section: Discussionmentioning

confidence: 99%

“…Advancing maternal age has been shown to be associated with adverse obstetric outcomes, such as gestational diabetes and pre-eclampsia, as well as adverse perinatal outcomes, such as caesarean section (CS) delivery [4,5]. Advanced maternal age was often referred to as maternal age of 35 years or older [6,7] but the term "elderly gravida" may now have little relevance-there is now growing literature that provides data on pregnancy outcomes in women aged 45 or older [8,9]. Much of this does not distinguish between spontaneous or artiWcial conception: this distinction is important because assisted reproductive techniques (ART) may themselves impact upon the outcomes of the pregnancy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal and neonatal outcomes of spontaneously conceived pregnancies in mothers over 45 years: a review of the literature

Wong-Taylor

Lawrence

Cowen

et al. 2012

Arch Gynecol Obstet

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal and neonatal outcomes of spontaneously conceived pregnancies in mothers over 45 years: a review of the literature

Wong-Taylor

Lawrence

Cowen

et al. 2012

Arch Gynecol Obstet

View full text Add to dashboard Cite

show abstract

“…This new trend is driven, in part, by developments in assisted reproductive technologies (ART), such as oocyte donation. These new technologies offer childbearing options for women in the 5th and 6th decades of life [5,7,8]. At present, approximately 0.1–0.2% births in Australia are to women aged 45 years or older [1] and this trend is likely to continue as newer technologies emerge.…”

Section: Introductionmentioning

confidence: 99%

“…Current evidence also suggests that adverse pregnancy outcomes among women aged 45 years or older are in excess of those experienced by women of less advanced maternal age (35–39 years) [8,13,14]. However, despite this pattern of increased risk, some questions remain unanswered.…”

Section: Introductionmentioning

confidence: 99%

Very advanced maternal age and morbidity in Victoria, Australia: a population based study

Carolan

Davey

Biró

et al. 2013

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundIn Australia, approximately 0.1% of births occur to women 45 years or older and this rate has been increasing in recent years. There are however, few population based studies examining perinatal outcomes among this age group. The aim of this study was to determine the maternal and perinatal outcomes of pregnancies in women aged 45 years or older compared to women aged 30–34 years.MethodsData on births at 20 or more weeks’ gestation were obtained from the Victorian Perinatal Data Collection for the years 2005 and 2006. We examined selected maternal and perinatal outcomes for women of very advanced maternal age (VAMA) aged 45 years or older (n = 217) and compared them to women aged 30–34 years (n = 48,909). Data were summarised using numbers and percentages. Categorical data were analysed by Chi-square tests and Fisher’s exact test. Comparisons are presented using unadjusted odds ratios, 95 percent confidence intervals (CIs) and p-values.ResultsWomen aged 45 years and older had higher odds of gestational diabetes (OR 2.05; 95% CI 1.3–3.3); antepartum haemorrhage (OR 1.89; 95% CI 1.01–3.5), and placenta praevia (OR 4.88; 95% CI 2.4–9.5). The older age-group also had higher odds of preterm birth between 32–36 weeks (OR 2.61; 95% CI 1.8–3.8); low birth-weight (<2,500 gr) (OR 2.22; 95% CI 1.5–3.3) and small for gestational age (OR 1.53; 95% CI 1.0–2.3). Stratified analysis revealed that VAMA was most strongly associated with caesarean section in primiparous women (OR 8.24; 95% CI 4.5, 15.4) and those using ART (OR 5.75; 95% CI 2.5, 13.3), but the relationship persisted regardless of parity, ART use and plurality. Low birthweight was associated with VAMA only in first births (OR 3.90; 95% CI 2.3, 6.6), while preterm birth was more common in older women for both first (OR 3.13; 95% CI 1.8, 5.3) and subsequent (OR 2.08; 95% CI 1.2, 3.5) births, and for those having singleton births (OR 2.11; 95% CI 1.3, 3.4), and those who did not use ART (OR 2.10; 95% CI 1.3, 3.4). Preterm birth was very common in multiple births and following ART use, regardless of maternal age.ConclusionsThis study demonstrates that women aged 45 years and older, in Victoria, Australia, have higher rates of pregnancy and perinatal complications, compared to women aged 30–34 years.

show abstract

“…7 In a group of primiparous pregnant women from Israel with advanced maternal age, the percentage of cesarean sections was 92.4% for the subgroup aged 45 to 49 years and 100% for the subgroup aged 50 to 65 years. 14 In our study, we could not analyze this particular subgroup due to the small number of patients older than 45 years (3 patients).…”

mentioning

confidence: 93%

Childbearing after 40 Years: A Challenge of the Modern Obstetrics

Stamatian¹,

Mureşan²,

Rotar³

et al. 2014

Donald School Journal of Ultrasound in Obstetrics and Gynecology

View full text Add to dashboard Cite

Aim: Age at delivery has increased in the past decades, leading to a continuous growth of the number of women planning a pregnancy after the age of forty. Because delivering after this age is associated with an increased rate of maternal compli cations, the objective of this study was to analyze the delivery related issues in women ≥40 years of age. Materials and methods:This was a retrospective study con ducted in the 1st Clinic of Obstetrics and Gynecology, Cluj Napoca in a 3year period. One hundred and fortytwo patients ≥40 years of age that delivered between 2010 and 2012 were included in the analysis. Results:The frequency of deliveries after the age of 40 was 2.42% of all the deliveries. Eighty percent of nulliparous and 51.72% of multiparous women delivered by cesarean section. A significantly higher percentage of primiparous women deli vered by cesarean section compared to secundiparous women (p = 0.0007). Fetal weight was significantly higher in multiparous than in primiparous women in the CS group (p = 0.01). No differences were observed between the Apgar scores according to the delivery mode or parity in the study group.Conclusion: Delivery after 40 years of age is associated with an increased number of obstetrical interventions.

show abstract

Primiparity at Very Advanced Maternal Age (≥45 years)

Cited by 29 publications

References 42 publications

Maternal and neonatal outcomes of spontaneously conceived pregnancies in mothers over 45 years: a review of the literature

Maternal and neonatal outcomes of spontaneously conceived pregnancies in mothers over 45 years: a review of the literature

Very advanced maternal age and morbidity in Victoria, Australia: a population based study

Childbearing after 40 Years: A Challenge of the Modern Obstetrics

Contact Info

Product

Resources

About