Primitive neuro-ectodermal tumor of the lung in an adult

Gaude, Gajanan S; Pr, Malur; Kangale, R; Anurshetru, Shivappa Basavaraj

doi:10.4103/0970-2113.53233

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…Although the use of cardiopulmonary bypass may slightly increase the risk of blood metastases, the benefits of achieving complete resection far outweigh the potential risk [ 9 ]. Therefore, complete resection should be considered as the first choice [ 10 ]. It is important to emphasize the necessity of pericardial patch repair because simultaneous excision of the affected pericardial tissue and lung may lead to cardiac torsion or heart hernia.…”

Section: Discussionmentioning

confidence: 99%

Operative treatment of pulmonary primitive neuroectodermal tumor: a case report and literature review

Zhang,

Shang,

et al. 2024

J Cardiothorac Surg

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Background Pulmonary primitive neuroectodermal tumor (PNET), a member of the Ewing sarcoma family of tumors, is a rare malignancy that is associated with a grim prognosis. To date, fewer than 30 cases of pulmonary PNET have been reported. In this case report, we present the clinical details of a 12-year-old girl with pulmonary PNET who underwent surgical treatment. We also conducted an analysis and summary of other relevant studies and the surgical outcomes. Case presentation In May 2018, a 12-year-old girl was admitted with symptoms of cough and blood-tinged phlegm. A computed tomography scan revealed a large mass, measuring 12.9 cm × 8.1 cm, in the right middle and lower lungs. A percutaneous lung biopsy confirmed poorly differentiated tumor cells with a nested growth pattern. Immunohistochemical staining demonstrated positive expression of CD99, CD56, Vimentin, and Synaptophysin. The patient was diagnosed with pulmonary PNET. Following three cycles of neoadjuvant chemotherapy, a substantial reduction in tumor volume was observed. Subsequently, the patient underwent a surgical procedure involving pneumonectomy and partial resection of the left atrium with the assistance of cardiopulmonary bypass. The patient was discharged 37 days after surgery. During a three-year follow-up period, she exhibited no signs of tumor recurrence and has successfully returned to school. Conclusions This case highlights the successful management of an advanced PNET with neoadjuvant chemotherapy, pneumonectomy, and partial resection of the left atrium employing cardiopulmonary bypass. The patient remained disease-free after three years. Our analysis of surgically treated cases indicates that neoadjuvant chemotherapy can contribute to improved prognoses for PNET patients. It is crucial to emphasize that complete surgical excision remains the cornerstone of treatment, underscoring the importance of surgeons considering radical surgical approaches whenever feasible for patients with pulmonary PNETs.

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Section: Discussionmentioning

confidence: 99%

Operative treatment of pulmonary primitive neuroectodermal tumor: a case report and literature review

Zhang,

Shang,

et al. 2024

J Cardiothorac Surg

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Peripheral Neuroectodermal Tumour (Pnet) Lung Diagnosed by Fnac: A Rare Case Report

Chari¹,

Singh²,

Nayak³

2014

jemds

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We report a rare case of peripheral neuro-ectodermal tumor (PNET) in lung diagnosed by USG-guided FNAC in lung of a 19 year old male, who presented with cough, hemoptysis and pleuritic chest pain. CT chest showed a homogeneous mass in left posterior segment of lung with areas of necrosis. CT abdomen and bone scan studies were normal. Fine needle aspiration (FNA) revealed cellular smears comprised of small round blue cells arranged in rosettes, sheets, blue cells having fine chromatin, scant cytoplasm in an inflammatory background. Biopsy was advised for evaluation of small round blue cell to further typing and confirmation for further management. CTguided trucut biopsy revealed lesion with small round blue cells had round nuclei, fine chromatin with scant cytoplasm arranged in sheets, rosettes in thin fibrous septae. Immunohistochemistry (IHC) showed malignant cells were positive for CD 99, synaptophysin and chromogranin and negativity for CD45 and Cytokeratin.

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Rare Primary Pulmonary Primitive Neuroectodermal Tumor: A Case Report and Literature Review

Wang

Dong

et al. 2021

OTT

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Primitive neuro-ectodermal tumor of the lung in an adult

Cited by 3 publications

References 8 publications

Operative treatment of pulmonary primitive neuroectodermal tumor: a case report and literature review

Operative treatment of pulmonary primitive neuroectodermal tumor: a case report and literature review

Peripheral Neuroectodermal Tumour (Pnet) Lung Diagnosed by Fnac: A Rare Case Report

Rare Primary Pulmonary Primitive Neuroectodermal Tumor: A Case Report and Literature Review

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