Primordial Proteins and HIV

Sommer, Andrei P.; Pavláth, Attila E.

doi:10.1021/pr049795p

Cited by 14 publications

(54 citation statements)

References 34 publications

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“…31 The effect of the substrate material on pattern formation has been demonstrated on Cybernox (Sitram, France), a quasicrystalline material used for the production of nonstick fry pans; on it the employed apatite nanosuspension formed crystalline rings. 42 Arrows point to individual nanoparticles. Bars ) 5 µm.…”

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confidence: 99%

Superadhesion: Attachment of Nanobacteria to Tissues − Model Simulation

Sommer

Çehreli

Akça

et al. 2004

Crystal Growth & Design

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Adhesion is common in the bacterial world and is partially mediated by slime. Nanobacteria (NB) seem to attach by slime as well as by the protecting nanocrystalline apatite shell, securing their survival in hostile milieus. Identification of NB in the human heart has brought the particles into the focus of material scientists. In view of the size distribution of the apatite nanovesicles (80-300 nm), simulation of their interaction with tissues can be performed via nanosuspensions and mirror-polished titanium substrates. Due to its wide biocompatibility, titanium is an ideal body tissue substitute. Here we show in a model simulation that the apatite nanovesicles are likely to perform also an anchoring function, specific to the mineral apatite. Anchoring may prevent solitary NB from elimination from the body, and enforce existing toxic potentials. The capacity of the apatite nanoparticles to bind to tissues in aqueous liquids, and the pronounced tendency of NB to form mineralized biofilms, indicate that NB could affect intracardiac fluid forces. Adhesion and protection represent a unique combination, which may stimulate the design of novel drug release systems based on apatite nanovesicles.

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confidence: 99%

Superadhesion: Attachment of Nanobacteria to Tissues − Model Simulation

Sommer

Çehreli

Akça

et al. 2004

Crystal Growth & Design

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“…However, due to a slime envelope, acting presumably also as a chemical barrier, before integration into the mineral shell, the collected components are transiently stored in the slime. 22 Growth implies the diffusion of the collected material across the slime film. The picture emerging from this process is a calcium phosphate gradient, perpendicular to the slime barrier.…”

Section: Primordial Proteinsscollection and Carrier Proteinsmentioning

confidence: 99%

“…4,19 The possibility that calcium phosphate, stored in the slime film coating NB, might be involved in the transfection of lymphocytes with viral nucleic acids seems realistic. 22 Slime could have been synthesized external to cells, or even upon entry. It should be explicitly pointed out that without the collection, storage, and carrier function of the primordial proteins, calcium phosphate would have only a small chance to infiltrate eukaryotic cells in vivo.…”

Section: Primordial Proteinsscollection and Carrier Proteinsmentioning

confidence: 99%

“…Due to the predominantly short proteins, slime coating NB will have a pronounced fluidity. 22 This indicates a spread of the slime on the nuclear membrane, exceeding the dimensions of the NB, thereby increasing the likelihood that viral DNA, prior to traversing the membrane, could contact fields with elevated levels of calcium phosphate. The spread of the slime could be limited by the residence time of the NB at the membrane, which may even cross the nuclear membrane, creating channels facilitating the entrance of viral DNA.…”

Section: Challenges For Clinical Studies and Laboratory Experimentsmentioning

confidence: 99%

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Primordial Proteins and HIVPart II

Sommer

2005

J. Proteome Res.

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Nanobacteria are suspected to be responsible for a number of diseases, i.e., kidney stones, heart disease, ovarian cancer, peripheral neuropathy, and reduced bone mineral density. Being protected by a mineral shell consisting of apatite, the nanovesicles can enter eukaryotic cells. Depending on the host's stress level, nanobacteria may carry a substantial layer of a protein based slime, instrumental in collecting calcium phosphate from the environment. Calcium phosphate is known to mediate the uptake of nucleic acids by eukaryotic cells. Surprisingly, a pathogenic effect of nanobacteria in HIV can be derived primarily from the trafficking of calcium phosphate in HIV infected cells, performed by primordial proteins. The inescapable conclusion is that nanobacteria could promote genetic diversity in HIV.

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“…Therefore, it seems reasonable to suspect NB as a common factor in diseases recurrent in populations as different as astronauts and patients infected with HIV. In HIV, NB may also play an active role, amplifying HIV infectivity, as indicated by the internalization of NB by cells, calcium phosphate in a slime layer coating NB and transfection of nucleic acids into cells (i.e., lymphocytes) mediated by calcium phosphate [1] .…”

Section: Introductionmentioning

confidence: 99%

Nanobacteria, HIV and Magic Bullets – Update of Perspectives 2005

Sommer¹,

Milánkovits

Mester

2006

Chemotherapy

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In 1997 a Finnish group speculated on the presence of nanobacteria in vaccines. In 2001, a report on the identification of nanobacteria in a number of vaccines attracted much attention. Experiments indicated that viable nanobacteria are excreted via urine. Their extreme survivability suggests that prior to discussing any possible contamination of vaccines, sources and routes of natural infection need to be examined. In view of 30,000,000 HIV infections in sub-Saharan Africa, the recently reported occurrence of nanobacteria in HIV-infected patients deserves concern. Clearly, it could indicate the origin of a giant reservoir and dissemination cycle. Here we discuss novel therapeutic strategies to prevent or reduce nanobacterial infection. In regard of the rapid progress in this field, we start with a brief introductory summary, and analyze possible implications.

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Primordial Proteins and HIV

Cited by 14 publications

References 34 publications

Superadhesion: Attachment of Nanobacteria to Tissues − Model Simulation

Superadhesion: Attachment of Nanobacteria to Tissues − Model Simulation

Primordial Proteins and HIVPart II

Nanobacteria, HIV and Magic Bullets – Update of Perspectives 2005

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