Principles of Accelerated Corneal Collagen Cross-Linking

Mazzotta, Cosimo; Raiskup, Frederik; Baiocchi, Stefano; Scarcelli, Giuliano; Friedman, Marc D.; Traversi, Claudio

doi:10.1007/978-3-319-61137-2_1

Cited by 2 publications

(1 citation statement)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mazzotta et al 74 demonstrated by means of comparative corneal OCT and IVCM scans that the DL depth achievable after the 9mW/cm 2 A-CXL protocol with 5.4J/cm 2 fluence and 10 minutes of continuous light UV-A exposure was at 310 ± 30 µm depth on average measured from the epithelial surface, Figure 4 g -h, nearer to S-CXL 3mW/cm 2 Dresden protocol (350 µm measured from the epithelial surface), Figure 4 i -l. In a recent study Hashemi et al 60 documented that A-CXL with 18mW/cm 2 UV-A power showed less topographic flattening compared with conventional CXL. Refractive and visual results of the A-CXL by using continuous light and pulsed light treatment at 30mW/cm 2 gave similar results compared to conventional 3mW/cm2 CXL after 12-months follow-up.…”

Section: -Dmentioning

confidence: 99%

The meaning of the demarcation line after riboflavin-UVA corneal collagen crosslinking

Mazzotta

Wollensak

Raiskup³

et al. 2019

Expert Review of Ophthalmology

Self Cite

View full text Add to dashboard Cite

Since at least two decades, corneal cross-linking by riboflavin and UV-A irradiation stands as an established treatment option of progressive corneal ectasia. More than ten years ago, the histological evaluation of animal corneas and later of human corneas by means of in vivo biomicroscopy and scanning laser confocal microscopy demonstrated in corneas treated with cross-linking procedure the occurrence of a demarcation line running almost parallel to the corneal surface. The feature is a direct consequence of the cross-linking-induced photooxidative modification of the stromal tissue due to riboflavin stromal concentration, light distribution within the corneal stroma, riboflavin activation, oxygen availability and diffusion in the corneal stroma, radicals release, and UV-A exposure time. In this study, the general role of the demarcation line observed after a corneal cross-linking process, in particular its mechanical relevance, clinical consequences, and other various findings in the numerous nowadays available modalities of this treatment, are reviewed objectively.

show abstract

Section: -Dmentioning

confidence: 99%

The meaning of the demarcation line after riboflavin-UVA corneal collagen crosslinking

Mazzotta

Wollensak

Raiskup³

et al. 2019

Expert Review of Ophthalmology

Self Cite

View full text Add to dashboard Cite

show abstract

A wireless battery-free eye modulation patch for high myopia therapy

Zhong,

Yi,

Gou

et al. 2024

Nat Commun

View full text Add to dashboard Cite

The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch consists of piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. The system can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator plays a key role in precisely shortening the axial length by driving the posterior sclera inward. This ensures accurate scene imaging on the retina for myopia eye. The drug microneedle array delivers riboflavin to the posterior sclera, and μ-LEDs’ blue light induces collagen cross-linking, reinforcing sclera strength. In vivo experiments demonstrate that the patch successfully reduces the rabbit eye’s axial length by ~1217 μm and increases sclera strength by 387%. The system operates effectively within the body without the need for batteries. Here, we show that the patch offers a promising avenue for clinically treating high myopia.

show abstract

Principles of Accelerated Corneal Collagen Cross-Linking

Cited by 2 publications

References 90 publications

The meaning of the demarcation line after riboflavin-UVA corneal collagen crosslinking

The meaning of the demarcation line after riboflavin-UVA corneal collagen crosslinking

A wireless battery-free eye modulation patch for high myopia therapy

Contact Info

Product

Resources

About