It is known that cows high milk productivity is associated with decrease in resistance to various diseases, including bovine leukosis, in resistance formation to which the BoLA-DRB3 gene plays role, whose alleles are associated with resistance (R-alleles *7, *11, *23, *28), sensitivity (S-alleles *8, *16, *22, *24) or are defined as neutral (N) in relation to the disease. Researchers also established association of BoLA-DRB3-alleles *8, *11, *23 with an increased milk yield volume, and the *22 allele - with reduced milk yield volume. The aim of research was to study associative communication of servicing bulls BoLA-DRB3 genotypes groups with their breeding value by female ancestor’s dairy productivity indicators. As a result, we studied associative communication of servicing bulls BoLA-DRB3 genotypes groups with their breeding value by female ancestor’s dairy productivity indicators with identification of reduced milk productivity with genetic resistance to bovine leukemia virus infection and bovine leukosis disease relationship, as well as observation of positive correlation between increased milk productivity and genetic predisposition to increased milk yield volumes. The obtained information will be taken into account in breeding during dairy herds reproduction with genetic resistance to bovine leukosis.