Principles of Wound Management and Wound Healing in Exotic Pets

Mickelson, Megan A.; Mans, Christoph; Colopy, Sara A.

doi:10.1016/j.cvex.2015.08.002

Cited by 48 publications

(38 citation statements)

References 33 publications

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“…During the wound healing process, type III collagen is replaced by type I collagen, which provides tensile stiffness. Collagen fibers remodel by aligning with the body's tension lines and gaining strength through cross-linking [7][8][9][10]. In this final stage of healing, an attempt to recover the normal tissue structure occurs, and the granulation tissue is gradually remodeled, forming scar tissue [10,11].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Quantification of the Effectiveness of Topical Low-Dose Photodynamic Therapy in Wound Healing Using Two-Photon Microscopy

et al. 2022

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The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm2). A second-harmonic-generation-to-auto-fluorescence aging index of the dermis (SAAID) was analyzed by two-photon microscopy. SAAID measured at 60–80 μm depths was shown to be a suitable quantitative parameter to monitor wound healing. A comparison of SAAID in healthy and wound tissues during phototherapy showed that both light doses were effective for wound healing; however, healing was better at a dose of 4 J/cm2.

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Section: Introductionmentioning

confidence: 99%

In Vivo Quantification of the Effectiveness of Topical Low-Dose Photodynamic Therapy in Wound Healing Using Two-Photon Microscopy

et al. 2022

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“…Synthetic biodegradable polymers normally applied in wound regenerations include polyxylitol, polyethylene oxide (PEO), polyhydroxyl butyrate, polyvinylalcohol (PVA) and polyurethane [11]. Their hydrophilic nature grants significant utilitarian injury repair qualities, for example, dampness ingestion limit and water absorption capacity, which permit support of a sodden injury condition while maintaining a strategic distance from the assortment of overabundance exudates [12]. The engineered polymeric wound covering materials can be created utilizing different procedures, for example, electrospinning and hydrogel synthesis [9].…”

Section: Introductionmentioning

confidence: 99%

Ficus carica extract impregnated amphiphilic polymer scaffold for diabetic wound tissue regenerations

Feng

Yu²,

Zhang³

et al. 2021

Artificial Cells, Nanomedicine, and Biotechnology

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Diabetes associated injury healing and other tissue irregularities are viewed as a significant concern. The purpose of the study is to design the wound regeneration activity of Ficus carica extract (FFE) loaded amphiphilic polymeric scaffold of poly(xylitol-g-adipate-co-glutamide) (PXAG)-polyhydroxybutyrate (PHB) for potential diabetic affected wound regeneration. The PXAG copolymer was prepared by the condensation method, and the polymeric scaffolds of PXAG-PHB, PXAG-PHB/FFE were developed through the ultra-sonication process and magnetic stirrer processes. The chemical structure, crystalline nature, thermal stability, size, surface charge and surface morphology of PXAG-PHB and PXAG-PHB/FFE polymeric scaffolds were investigated. The PXAG-PHB/FFE exhibits 99.0% free radical scavenging activity which was determined by the DPPH method. The inhibition zones by the PXAG-PHB/FFE indicate it had a higher antibacterial activity with the Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) pathogens. The PXAG, PXAG-PHB and PXAG-PHB/FFE polymeric scaffolds exhibited good viability against diabetic induced wound cells (WS1) in 100 lg/mL concentrations up to 72 h incubation. Since the synthesized PXAG-PHB/FFE polymeric scaffolds possess excellent thermal stability, bioactivity, biocompatibility and antioxidant activity along with potent antimicrobial activity, they play a potential role in diabetic wound tissue regenerations.

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“…Comparison with a standard therapy has been advocated for all clinical studies assessing O 3 as a new therapy in human patients [ 3 ]. In reptiles, there are neither previous studies evaluating O 3 therapy nor any well-defined standard topical treatments to manage wound healing by second intention [ 20 24 ]. A decision was made not to have a control group given no treatment whatsoever, because vegetable oils, such as sunflower oil, may promote cutaneous wound healing [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of topical ozonated sunflower oil on second intention wound healing in turtles: a randomised experimental study

et al. 2021

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Background Ozone is an antimicrobial agent that in experimental and case-control studies has been found to exert a positive effect on wound healing. Wild and pet chelonians frequently present insidious wounds exhibiting secondary infections and/or delayed healing. Objectives Evaluate the effects of topical ozonated sunflower oil on second-intention healing of acute experimental skin wounds in red-eared sliders ( Trachemys scripta elegans ). Methods Randomised within-subject controlled study; Group 1 (n = 24) was used to assess clinical healing features; Group 2 (n = 12) was used for histological evaluation in which two sets of wounds were biopsied at 2, 7, 14, 21, 28 and 42 days over the course of the cicatrisation process. A single 6 mm diameter wound was made on each rear limb and topical ozonated (950 peroxide value) and non-ozonated sunflower oil were applied daily for one week on treated and contralateral control wounds, respectively. Results Mean wound size was significantly lower in the ozone-treated group at day 28 ( p < 0.0001) with differences of clinical relevance (74.04% vs. 93.05% reduction of initial wound size). Histologically, the acute inflammatory reaction was enhanced in treated wounds, with significantly higher numbers of heterophils ( p = 0.0016), lymphocytes ( p < 0.001) and fibroblasts ( p < 0.001). Conclusions Daily topical application of ozonated sunflower oil over the course of one week improved the healing of acute, full-thickness skin wounds in chelonians. This clinical outcome was histologically correlated with an enhanced acute inflammatory reaction, as well as the production and remodelling of collagen fibres.

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Principles of Wound Management and Wound Healing in Exotic Pets

Cited by 48 publications

References 33 publications

In Vivo Quantification of the Effectiveness of Topical Low-Dose Photodynamic Therapy in Wound Healing Using Two-Photon Microscopy

In Vivo Quantification of the Effectiveness of Topical Low-Dose Photodynamic Therapy in Wound Healing Using Two-Photon Microscopy

Ficus carica extract impregnated amphiphilic polymer scaffold for diabetic wound tissue regenerations

Effect of topical ozonated sunflower oil on second intention wound healing in turtles: a randomised experimental study

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