Prior statin and short‐term outcomes of primary intracerebral hemorrhage: From a large‐scale nationwide longitudinal registry

Abstract

Introduction:The relationship between statins and intracerebral hemorrhage outcomes is unclear. Aim:We aimed to compare the in-hospital mortality and evacuation of intracranial hematoma rates in patients with primary intracerebral hemorrhage between prior statin users and nonusers. Results:The final study population included 66,263 patients. Multivariable logistics analyses showed that prior statin use was not associated with in-hospital mortality for primary intracerebral hemorrhage (adjusted odd ratio 0.78, 95% CI 0.61-1.01), but reduced the proportion of patients undergoing evacuation of intracranial hematoma (adjusted odd ratio 0.70, 95% CI 0.61-0.82). Propensity score matching analyses yielded similar results. Conclusion:Prior statin use was not associated with in-hospital mortality but did reduce evacuation of intracranial hematoma rates.

Higher fasting blood glucose was associated with worse in‐hospital clinical outcomes in patients with primary intracerebral hemorrhage: From a large‐scale nationwide longitudinal registry

“…Moreover, several clinical factors were associated with outcomes of ICH. Prior statin was associated with reduced proportion of evacuation of intracranial hematoma without increasing mortality during in‐hospitalization 26 . The cost‐effectiveness ratio of anticoagulant therapy is still uncertain in ICH and more investigations are warranted, 27,28 as well as the role of platelets and onset time that have been studied in subarachnoid hemorrhage 29 and ischemic stroke 30 …”