Prior statin therapy is associated with milder course and better outcome in acute pancreatitis – A cohort study

Prior statin use and the outcomes in patients with first-attack acute pancreatitis: A retrospective cohort study

“…Therefore, these findings could not conclude that statins were beneficial in patients with AP. In another cohort study, the pancreatitis-associated mortality rate was higher in the no-statin group after matching, and the statin group presented a lower Ranson's score and Acute Physiology And Chronic Health Evaluation (APACHE) II score in patients with severe AP [6].…”

“…Regarding the cut-off value for evaluating the severity of AP, we defined severe pancreatitis when Ranson's score was ≥3 and the CTSI was ≥3 [12][13][14]. In one study, treatment of AP was possible in patients with a low CTSI (0-2) and high CTSI (7-10), but it was questionable for patients with an intermediate CTSI (3)(4)(5)(6) [13]. Therefore, we decided to include patients with an intermediate and high CTSI to evaluate the role of statin.…”

“…There was no relevant information to discuss the relationship between the therapeutic effects of statins on patients with AP and the etiology of AP from the subgroup analysis. Another prospective cohort study from 2013 also showed that prior statin treatment may reduce the pancreatitis-related mortality in AP [6]. It did not mention the dose-response relationship between statin use and the risk of AP.…”

Chronic use of statins and risk of post-ERCP acute pancreatitis (STARK): Study protocol for an international multicenter prospective cohort study

“…3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG co-A) reductase inhibitors (statins) are effective and commonly used worldwide as a treatment for dyslipidemia [5], and increasing evidence shows that statins also have anti-inflammatory effects [5,6]. Earlier reports suggested a potential association of statins to an increased risk of AP, however, several recent studies have demonstrated that the use of statins may actually be a protective factor against AP [7][8][9][10][11]. A meta-analysis of randomized controlled trials suggested that the use of statins is associated with a lower risk of pancreatitis [9].…”

Simvastatin is associated with reduced risk of acute pancreatitis: findings from a regional integrated healthcare system

“…Several case reports suggest an increased risk of AP with use of statins, in particular simvastatin 3–6 However, more recent literature suggests a possible protective effect 78 As statins are now among the most widely prescribed medications worldwide, understanding the potential link between these medications and AP is of significant clinical importance.…”