Pristimerin suppresses colorectal cancer through inhibiting inflammatory responses and Wnt/β-catenin signaling

Zhao, Qun; Bi, Yunbo; Zhong, Jing; Ren, Ziting; Liu, Yingxiang; Jia, Junjun; Yu, Mengting; Tan, Yan; Zhang, Qiufang; Lei, Yu

doi:10.1016/j.taap.2019.114813

Cited by 41 publications

(31 citation statements)

References 74 publications

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“…21 Increasing studies demonstrated that abnormal expression of genes was associated with tumorigenesis and progression of cancers, including miRNAs. 22,23 For instance, miR-205 was found involved in the angiogenesis and progression of thyroid cancer. 24 Numerous studies have also demonstrated that aberrant expression of miRNAs was involved in the development and progression of colon cancer, such as miR-183 25 and miR-137.…”

Section: Discussionmentioning

confidence: 99%

<p>Upregulation of MiR-1274a is Correlated with Survival Outcomes and Promotes Cell Proliferation, Migration, and Invasion of Colon Cancer</p>

Ren

Yang

et al. 2020

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Purpose: Colon cancer has become one of the primary causes of cancer-related mortality in recent years. MicroRNAs (miRNAs) play important roles in the regulation of target genes expression. Some of these molecules are aberrantly expressed in colon cancer. The aim of this study was to investigate the potential role of miR-1274a in colon cancer. Patients and Methods: The expression levels of miR-1274a in colon cancer tissues and cell lines were detected using RT-qPCR. The association between miR-1274a expression and clinical features was analyzed by the χ 2 test. Then the Kaplan-Meier method and multivariate Cox regression analysis were used to explore the clinical prognostic significance of miR-1274a in colon cancer. Finally, the effects of miR-1274a on cell growth, migration, and invasion were investigated with the CCK-8 assay, colony formation assay, transwell migration, and invasion assays, respectively. Results: The expression of miR-1274a was increased in colon cancer tissues and cell lines. The miR-1274a expression was associated with lymph node metastasis, vascular invasion, and TNM stage. Patients with high miR-1274a expression had a poor overall survival time compared with those with low miR-1274a expression. Upregulated miR-1274a promoted cell proliferation, migration, and invasion of colon cancer cells, while inhibition of miR-1274a suppressed these cellular activities by targeting FOXO4. Conclusion: Our study suggested that miR-1274a might function as an oncogene in human colon cancer and be a potential prognostic biomarker and therapeutic target for the treatment of colon cancer.

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Section: Discussionmentioning

confidence: 99%

<p>Upregulation of MiR-1274a is Correlated with Survival Outcomes and Promotes Cell Proliferation, Migration, and Invasion of Colon Cancer</p>

Ren

Yang

et al. 2020

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“…The scoring of stool consistency and occult blood was performed as previously described 26 . The disease activity index (DAI) was determined based on the combined score.…”

Section: Methodsmentioning

confidence: 99%

MLKL inhibits intestinal tumorigenesis by suppressing STAT3 signaling pathway

Zhao¹,

Cheng²,

Guo³

et al. 2021

Int. J. Biol. Sci.

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Mixed lineage kinase domain-like protein (MLKL) plays an important role in necroptosis, but the role and mechanism of MLKL in intestinal tumorigenesis remain unclear. Here, we found that hematopoietic- and nonhematopoietic-derived MLKL affected intestinal inflammation, but nonhematopoietic-derived MLKL primarily inhibited intestinal tumorigenesis. Loss of MLKL enhanced intestinal regeneration and the susceptibility to intestinal tumorigenesis in Apc min/+ mice by hyperactivating the Janus kinase 2 (JAK2)/ signal transducer and activator of transcription 3 (STAT3) axis. Furthermore, MLKL deficiency increased interleukin-6 (IL-6) production in dendritic cells. Administration of anti-IL-6R antibody therapy reduced intestinal tumorigenesis in Apc min/+ Mlkl -/- mice. Notably, low MLKL expression in human colorectal tumors, which enhanced STAT3 activation, was associated with decreased overall survival. Together, our results reveal that MLKL exhibits a suppressive effect during intestinal tumorigenesis by suppressing the IL-6/JAK2/STAT3 signals.

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“…It has been extensively investigated mainly by its inhibitory activity against cancer cell growth. Pristimerin inhibited Wnt/β-catenin signaling via GSK3β activation and Wnt gene suppression in colorectal cancer cells [337]. In addition, Yousef and colleagues demonstrated pristimerin anticancer activity on colon tumor cells associated to NF-κB signaling inhibition during the carcinogenic process [338,339].…”

Section: Pristimerinmentioning

confidence: 99%

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

et al. 2020

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Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9-tetrahydrocannabinol (Δ9-THC)—as well as the G-protein-coupled cannabinoid receptors (CBR), named cannabinoid receptor type-1 (CB1R) and cannabinoid receptor type-2 (CB2R), both part of the now known endocannabinoid system (ECS). Cannabinoids is a vast term that defines several compounds that have been characterized in three categories: (i) endogenous, (ii) synthetic, and (iii) phytocannabinoids, and are able to modulate the CBR and ECS. Particularly, phytocannabinoids are natural terpenoids or phenolic compounds derived from Cannabis sativa. However, these terpenoids and phenolic compounds can also be derived from other plants (non-cannabinoids) and still induce cannabinoid-like properties. Cannabimimetic ligands, beyond the Cannabis plant, can act as CBR agonists or antagonists, or ECS enzyme inhibitors, besides being able of playing a role in immune-mediated inflammatory and infectious diseases, neuroinflammatory, neurological, and neurodegenerative diseases, as well as in cancer, and autoimmunity by itself. In this review, we summarize and critically highlight past, present, and future progress on the understanding of the role of cannabinoid-like molecules, mainly terpenes, as prospective therapeutics for different pathological conditions.

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Pristimerin suppresses colorectal cancer through inhibiting inflammatory responses and Wnt/β-catenin signaling

Cited by 41 publications

References 74 publications

<p>Upregulation of MiR-1274a is Correlated with Survival Outcomes and Promotes Cell Proliferation, Migration, and Invasion of Colon Cancer</p>

<p>Upregulation of MiR-1274a is Correlated with Survival Outcomes and Promotes Cell Proliferation, Migration, and Invasion of Colon Cancer</p>

MLKL inhibits intestinal tumorigenesis by suppressing STAT3 signaling pathway

Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant

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