Prkra Mutation Alters circRNA Expression During Embryonic External Ear Development

Abstract

: The changes in circRNA expression profile in the mouse external ear tissue during embryonic development to E15.5 and E17.5 can provide clues for the study of the regulation of external ear embryonic development. To understand the changes in gene regulation and expression of circRNA involved in mouse external ear embryonic development, a Prkra Little ear mouse model was used, and the changes in circRNA expression profiles were detected using next-generation sequencing. The changes in the expression of circRNA in the experimental group compared with those in the control group were identified using the find_circ and CiRi2 software, and the differentially expressed circRNAs were annotated via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. The results show that the development of mouse external ear embryos is regulated by circRNA expression.

Changes in Transcriptome-Associated Co-Expression Profile of Embryonic External Ear Development After Prkra Gene Mutation

“…This study was approved by the Medical Ethics Committee of the same hospital (Registration No. 2018-14) 3…”