Pro- and antioxidant activity of chromium(III), iron(III), molybdenum(III) or nickel(II) and their mixtures

Terpiłowska, Sylwia; Siwicki, Andrzej K.

doi:10.1016/j.cbi.2018.10.028

Cited by 41 publications

(26 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Roczniak et al [4] also noted that there is~50% more Ni concentration in the meniscus compared to the tibia and femur. It has been shown that Mo and Ni may contribute to lipid peroxidation and oxidative stress [41,42] which, according to recent studies, is significantly related to OA progression [43]. Nickel is probably absorbed through transport with interaction of Fe found in the hemoglobin and participates in oxygen transport [44,45].…”

Section: Discussionmentioning

confidence: 99%

Impact of Varied Factors on Iron, Nickel, Molybdenum and Vanadium Concentrations in the Knee Joint

Kot

Kosik-Bogacka

Ziętek

et al. 2020

IJERPH

View full text Add to dashboard Cite

The aim of this study was to determine the concentrations of iron, nickel, molybdenum, and vanadium in the knee joint. We also examined the relationships between the concentrations of these metals in the knee joint and the influence of varied factors on the concentration of Fe, Ni, Mo, and V. The study of these trace elements is important, because these elements are used alone and in combination in diet supplements, and they are components of biomaterials implanted in medicine. The study materials, consisting of the spongy bone, cartilage, meniscus, anterior cruciate ligament (ACL), and infrapatellar fat pad, were obtained from 34 women and 12 men from northwestern Poland. The concentrations of Ni, Fe, Mo, and V were determined using spectrophotometric atomic absorption in inductively coupled argon plasma (ICP-AES). We found significantly higher Mo concentrations in the ACL of women than men. There was a significant difference in the Mo concentration in the spongy bone between patients from cities with fewer than 100,000 inhabitants and patients from cities with more than 100,000 residents. Iron concentrations in the spongy bone were higher in non-smoking patients and those who did not consume alcohol. Vanadium concentrations were higher in the infrapatellar fat pads in abstainers. In patients who had not undergone arthroscopy surgery, V concentration was lower in cartilage. The concentrations of V in the cartilage and infrapatellar fat pad were higher in osteoporotic patients than in non-osteoporotic patients. There were significant differences in Fe concentrations in the meniscus, with the lowest in osteoporotic patients. We noted lower Mo concentrations in the spongy bone of patients with rheumatoid arthritis. Furthermore, we noted some new interactions among metals in the studied structures of the knee joint. The results reported in this study show the influence of gender, place of residence, smoking, consumption of alcohol, arthroscopy surgery, osteoporosis, and rheumatoid arthritis on the Fe, Ni, Mo, and V concentrations in the studied structures of the knee joint.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of Varied Factors on Iron, Nickel, Molybdenum and Vanadium Concentrations in the Knee Joint

Kot

Kosik-Bogacka

Ziętek

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…The enhancement of their anticancer potential, for the reacting free ligands, could be related to their various structural features and would be attributable to redox-active molybdenum (VI) ions. [77,78] In general, the viability of HCT-116, MCF-7 and HepG2 cells, which treated with the test current reagents, decreased in a concentration-dependent manner, however, the anticancer activity of those studied reagents (MoO 2 -complexes and their free ligands) was less than the standard drug, vinblastine (Table S3). All the probed reagents were more cytotoxic against the MCF-7 cell line (b) and MoO 2 L1 presented the lowest IC 50 values.…”

Section: Anticancer Activity Evaluationmentioning

confidence: 95%

Bis‐dioxomolybdenum (VI) oxalyldihydrazone complexes: Synthesis, characterization, DFT studies, catalytic epoxidation potential, molecular modeling and biological evaluations

Adam

Ahmed

Elhady

et al. 2020

Applied Organom Chemis

View full text Add to dashboard Cite

Two cis‐bis‐dioxomolybdenum oxalylsalicylidenedihydrazone complexes (MoO2L1 and MoO2L2) were synthesized via the complexation of dioxomolybdenum (VI) acetylacetonate with oxalylsalicylidenedihydrazone (H2L1) and p‐sodium sulfonate oxalylsalicylidenedihydrazone (H2L2) bis‐Schiff base chelating ligands, respectively. The structures of the newly synthesized complexes were confirmed by 1H‐ and 13C‐NMR, IR, ultraviolet–visible and mass spectra, as well as elemental analyses (EA) and conductivity measurements. The spectrophotometric continuous variation method revealed the formation of 2: 1 (metal: ligand molar ratios). DFT studies were applied for the ligands and their Mo‐chelates. Interestingly, the bis‐MoO2(VI) oxalyldihydrazone complexes showed remarkable catalytic sufficiency towards the selective (ep)oxidation of 1,2‐cyclooctene, benzyl alcohol and thiophene using H2O2 or tert‐butyl hydroperoxide (tBuOOH) at 85 °C. Under aqueous conditions, the MoO2L2 (with p‐sodium sulfonate substituent) exhibited superior that of the MoO2L1 (without p‐NaSO3―group), highlighting the role of sodium sulfonate substituent in the catalytic progress of the Mo‐chelate. The ligands (H2L1 and H2L2) and their corresponding Mo‐complexes (MoO2L1 and MoO2L2) were assessed for their antitumor and antimicrobial activities. Furthermore, the antioxidant activity was also evaluated using the 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) and superoxide dismutase (SOD) assays. The binding nature between the Mo‐complexes and calf thymus DNA (ctDNA) was also studied within spectroscopic and hydrodynamic techniques.

show abstract

“…Antioxidant activity of chromium(III) is correlated to the dose applied as shown in several experiments. Incubation of BALB/3 T3 clone A31 cells and HepG2 cells with chromium(III) chloride concentration higher than 400 μM would induce the formation of oxidative stress, while lower optimized concentration (M = 100-200 μM) would increase superoxide dismutase and catalase antioxidant activities [7]. In vitro study on the effect of chromium(III) and chromium(VI) on catalase activity also showed this dose-dependent activity in which treatment of cell-free catalase using chromium(III) (dose range 1-5 × 10 −5 mol/L) and chromium(VI) (dose range 1-4 × 10 −5 mol/L) separately increased the catalase activity [158].…”

Section: Cutaneous Ageing (Anti-ageing)mentioning

confidence: 99%

“…Various studies have shown that numerous acute and chronic adverse effects can be caused by any dermal or systemic exposure of chromium species in human organ systems [6]. The toxicity and biological activity of chromium seem to be correlated directly with the concentration of corresponding chromium species [7]. In this case, chromium species have its optimum concentration to produce beneficial effects.…”

Section: Introductionmentioning

confidence: 99%

Dermatologic Toxicities and Biological Activities of Chromium

Jumina¹,

Harizal²

2021

Trace Metals in the Environment - New Approaches and Recent Advances

View full text Add to dashboard Cite

Chromium is a versatile metal with various industrial applications and biological activities. However, as a transition metal, this element forms several species, i.e. oxidation states of −4 to +6, with different degrees of toxicities that affect ecosystems and organisms including human beings. The skin is the outermost organ that usually interacts directly with chromium species in nature. These contact and interaction induce the formation of several acute and chronic negative effects including contact dermatitis, skin cancer, allergy, etc. In this chapter, toxicity and biological activity of several chromium species, such as chromium zero-valent, trivalent, hexavalent, will be reviewed to obtain better comprehension in chromium toxicity. Sources and routes of exposure, toxicity and possible treatment, and biological activity on the skin are arranged and explained systematically.

show abstract

Pro- and antioxidant activity of chromium(III), iron(III), molybdenum(III) or nickel(II) and their mixtures

Cited by 41 publications

References 25 publications

Impact of Varied Factors on Iron, Nickel, Molybdenum and Vanadium Concentrations in the Knee Joint

Impact of Varied Factors on Iron, Nickel, Molybdenum and Vanadium Concentrations in the Knee Joint

Bis‐dioxomolybdenum (VI) oxalyldihydrazone complexes: Synthesis, characterization, DFT studies, catalytic epoxidation potential, molecular modeling and biological evaluations

Dermatologic Toxicities and Biological Activities of Chromium

Contact Info

Product

Resources

About