2017
DOI: 10.3389/fphys.2017.00204
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Pro-angiogenic Role of Insulin: From Physiology to Pathology

Abstract: The underlying molecular mechanisms involve in the regulation of the angiogenic process by insulin are not well understood. In this review article, we aim to describe the role of insulin and insulin receptor activation on the control of angiogenesis and how these mechanisms can be deregulated in human diseases. Functional expression of insulin receptors and their signaling pathways has been described on endothelial cells and pericytes, both of the main cells involved in vessel formation and maturation. Consequ… Show more

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Cited by 53 publications
(62 citation statements)
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References 108 publications
(153 reference statements)
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“…As a result, glucose homeostasis is deregulated and ectopic lipid is over accumulated in liver, leading to a vicious cycle in obese and diabetic patients. In agreement with a pro‐tumorigenesis effect by hyperinsulinemia, insulin signaling stimulates cell growth, differentiation and migration . On the other hand, high glucose levels associated with obesity further promote cancer cell metabolism .…”
Section: Adipokinesmentioning
confidence: 84%
“…As a result, glucose homeostasis is deregulated and ectopic lipid is over accumulated in liver, leading to a vicious cycle in obese and diabetic patients. In agreement with a pro‐tumorigenesis effect by hyperinsulinemia, insulin signaling stimulates cell growth, differentiation and migration . On the other hand, high glucose levels associated with obesity further promote cancer cell metabolism .…”
Section: Adipokinesmentioning
confidence: 84%
“…Angiogenesis is a key process in cancer initiation and metastasis. Endothelial cells and pericytes are two key cell types that participate in vessel formation and maturation and both endothelial cells and pericytes express the insulin receptor (166). Insulin, through insulin-receptor network signaling regulates endothelial cell migration, proliferation, and production of VEGF vascular growth factors (Figure 6) (166).…”
Section: Angiogenesismentioning
confidence: 99%
“…Endothelial cells and pericytes are two key cell types that participate in vessel formation and maturation and both endothelial cells and pericytes express the insulin receptor (166). Insulin, through insulin-receptor network signaling regulates endothelial cell migration, proliferation, and production of VEGF vascular growth factors (Figure 6) (166). Emerging evidence highlights an important role for insulin signaling in deregulation of normal angiogenesis [see Escudero et al for a review of this topic (166)].…”
Section: Angiogenesismentioning
confidence: 99%
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“…However, the effects of exogenous insulin on atherosclerosis progression have not been sufficiently studied. Experimental studies demonstrate direct in vitro effects of insulin on angiogenesis, as well as on endothelial and arterial smooth muscle cell proliferation [13,14] . Nevertheless, this contention remains controversial, and there is no definitive settlement on the role of insulin in atherogenesis [15][16][17] .…”
Section: Introductionmentioning
confidence: 99%