Pro-inflammatory chemokines CCL2, chemerin, IP-10 and RANTES in human serum during an oral lipid tolerance test

Schmid, Andreas; Bala, Margarita; Leszczak, S.; Ober, I.; Buechler, Christa; Karrasch, Thomas

doi:10.1016/j.cyto.2016.02.010

Cited by 15 publications

(10 citation statements)

References 52 publications

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“…20 In humans, short-term high dose LA consumption reduced circulating pro-inflammatory cytokine levels. 21 However, we did not detect an association between plasma LA levels and markers of tumor necrosis factor pathway activation. For AA, there is firm evidence for a pro-inflammatory effect, 6 and we found a positive association with GDF-15 levels.…”

Section: Inflammation Lipid and Glucose Metabolismcontrasting

confidence: 71%

Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation

Skaare

Svensson

Jenssen

et al. 2018

Journal of Renal Nutrition

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Section: Inflammation Lipid and Glucose Metabolismcontrasting

confidence: 71%

Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation

Skaare

Svensson

Jenssen

et al. 2018

Journal of Renal Nutrition

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“…A significant reduction of circulating IP-10 concentration was observed as a consequence of triglyceride ingestion [71]. In our study, IP10 gene expression negatively correlated with T2D and dyslipidemia parameters.…”

Section: Discussionsupporting

confidence: 54%

Dyslipidemia rather than Type 2 Diabetes Mellitus or Chronic Periodontitis Affects the Systemic Expression of Pro- and Anti-Inflammatory Genes

Nepomuceno

Villela

Corbi

et al. 2017

Mediators of Inflammation

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A high percentage of type 2 diabetes mellitus (T2D) patients are also affected by dyslipidemia and chronic periodontitis (CP), but no studies have determined the gene expression in patients that are simultaneously affected by all three diseases. We investigated the systemic expression of immune-related genes in T2D, dyslipidemia, and CP patients. One hundred and fifty patients were separated into five groups containing 30 individuals each: (G1) poorly controlled T2D with dyslipidemia and CP; (G2) well-controlled T2D with dyslipidemia and CP; (G3) normoglycemic individuals with dyslipidemia and CP; (G4) healthy individuals with CP; (G5) systemic and periodontally healthy individuals. Blood analyses of lipid and glycemic profiles were carried out. The expression of genes, including IL10, JAK1, STAT3, SOCS3, IP10, ICAM1, IFNA, IFNG, STAT1, and IRF1, was investigated by RT-qPCR. Patients with dyslipidemia demonstrated statistically higher expression of the IL10 and IFNA genes, while IFNG, IP10, IRF1, JAK1, and STAT3 were lower in comparison with nondyslipidemic patients. Anti-inflammatory genes, such as IL10, positively correlated with parameters of glucose, lipid, and periodontal profiles, while proinflammatory genes, such as IFNG, were negatively correlated with these parameters. We conclude that dyslipidemia appears to be the primary disease that is associated with gene expression of immune-related genes, while parameters of T2D and CP were correlated with the expression of these important immune genes.

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“…It is worth noting that postprandial levels of triglyceride can be affected by many factors, for example, type of diet, time after a meal, and comorbidity. Therefore, an oral lipid tolerance test, 28 similar to the oral glucose tolerance test, is expected to have higher clinical significance compared to a random nonfasting triglyceride test. This hypothesis needs to be investigated in the future.…”

Section: Discussionmentioning

confidence: 99%

Fasting status modifies the association between triglyceride and all‐cause mortality: A cohort study

Fang

Wang

2022

Health Science Reports

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Background and Aims: Both fasting and non-fasting levels of triglyceride have been shown positively associated with all-cause mortality. It is unknown whether fasting status modifies this association. This study aimed to address this question.Methods: This study included 34,512 US adults (27,036 fasting and 7476 nonfasting participants). All-cause mortality was ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios of triglyceride for mortality.Results: This cohort was followed up for a mean of 13.0 years. During the follow-up, 8491 all-cause deaths were recorded. A 1-natural-log-unit increase in triglyceride was associated with an 8% higher multivariate-adjusted risk of all-cause mortality.Interaction analyses showed that fasting status interacted with triglyceride in predicting all-cause mortality. Sub-analyses showed that a 1-natural-log-unit increase in triglyceride was associated with a 17% higher multivariate-adjusted risk of all-cause mortality in the nonfasting subcohort; however, there lacked such an association in the fasting sub-cohort. Similarly, high (200-499 mg/dL) and very high levels of triglyceride (≥500 mg/dL) were associated with higher all-cause mortality risks compared with low normal triglyceride (<100 mg/dL) only in the nonfasting subcohort. Conclusion:This study found that, compared to fasting triglyceride, nonfasting triglyceride was more sensitive in predicting all-cause mortality. This study supports the initiatives by some guidelines to recommend the use of nonfasting triglycerides for risk assessment.

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Pro-inflammatory chemokines CCL2, chemerin, IP-10 and RANTES in human serum during an oral lipid tolerance test

Cited by 15 publications

References 52 publications

Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation

Plasma n-6 Polyunsaturated Fatty Acid Levels and Survival in Renal Transplantation

Dyslipidemia rather than Type 2 Diabetes Mellitus or Chronic Periodontitis Affects the Systemic Expression of Pro- and Anti-Inflammatory Genes

Fasting status modifies the association between triglyceride and all‐cause mortality: A cohort study

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