Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration

Gómez, Mercedes; Esparza, José L.; Nogués, María Rosa; Giralt, Mireia; Cabré, María; Domingo, José L.

doi:10.1016/j.freeradbiomed.2004.10.009

Cited by 95 publications

(73 citation statements)

References 40 publications

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“…A number of studies have shown that animals exposed to AlCl 3 have increased Al concentrations in liver, plasma, urinary, kidney [14], testis and serum [15], hippocampus [16], and brain [17,18]. In the present study, there has been a significant increase in liver Al level after AlCl 3 exposure.…”

Section: Discussionsupporting

confidence: 59%

Effects of Ellagic acid and Hesperetin on Levels of Some Elements in Livers of Aluminum-Induced Rats

Özkaya¹,

Ciftci²,

Dayangac³

et al. 2013

Turk J Bioch

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Section: Discussionsupporting

confidence: 59%

Effects of Ellagic acid and Hesperetin on Levels of Some Elements in Livers of Aluminum-Induced Rats

Özkaya¹,

Ciftci²,

Dayangac³

et al. 2013

Turk J Bioch

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“…Increased activities of GPx and Cu-Zn SOD/Mn-SOD in the rat brain after exogenous administration of melatonin has been reported [38]. Gomez et al [39] observed increased levels of each of Cu-ZnSOD, MnSOD, GPx and CAT in the hippocampi of rats after melatonin administration.…”

Section: Discussionmentioning

confidence: 85%

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

et al. 2012

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This study aimed to elucidate the mechanisms of melatonin to manage neurological damage in Alzheimer's disease (AD) induced in ovariectomized rats. Forty adult female rats were enrolled in our study and were classified as; gonad intact control, ovariectomized control group, ovariectomized rats received melatonin, ovariectomized rats injected with AlCl 3 to induce AD and ADinduced rats treated with melatonin. Hydrogen peroxide (H 2 O 2 ), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), acetylcholinesterase (AchE) and acetylcholine (Ach) were estimated in the brain tissues of the different groups. Treatment of AD-induced rats with melatonin produced marked improvement in the most studied biomarkers which was confirmed by histological investigation of the brain. In Conclusion, melatonin significantly ameliorates the neurodegeneration characteristic of AD in experimental animal model due to its antioxidant, antiapoptotic, neurotrophic and anti-amyloidogenic activities.

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“…Generally speaking, melatonin provides protective cellular effects, especially for mitochondria, and it prevents the damage of proteins, lipids, and DNA (Zhang and Zhang, 2014). In vivo experiments pointed out that melatonin increases gene expression of multiple antioxidative genes in neuronal tissues, including those of CuZnSOD, MnSOD, GPx, catalase, and glutathione reductase (Kotler et al, 1998;Esparza et al, 2005;Gomez et al, 2005).…”

Section: Antioxidative Effects Of Melatoninmentioning

confidence: 99%

Prooxidant effects of melatonin: a brief review

Munik¹,

Ekmekçioğlu²

2015

Turk J Biol

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IntroductionMelatonin, chemically N-acetyl-5-methoxytryptamine, was primarily isolated from bovine pineal glands and its structure was first identified in 1958 (Lerner et al., 1958). This indolamine was later discovered to be also present or synthesized in extrapineal tissues such as the retina, gastrointestinal tract, Harderian gland, testes, and lymphocytes (Reiter et al., 2013). Due to the fact that melatonin possesses hydrophilic and lipophilic characteristics, its lipophilic ability enables it to penetrate all biological membranes, including the blood-brain barrier (Reiter et al., 1997). Generally, melatonin derives from the essential amino acid tryptophan by a multistep enzymatic reaction chain, including tryptophan 5-hydroxylation, decarboxylation, N-acetylation, and O-methylation. Furthermore, melatonin can be synthesized via O-methylation of serotonin and subsequent N-acetylation of 5-methoxytryptamine, or by O-methylation of tryptophan, followed by decarboxylation and N-acetylation (Hardeland et al., 1993). From a functional perspective, melatonin is characterized as a hormone involved in the regulation of the circadian rhythm of several biological functions and it also plays an important role in immunoregulation, reproduction, sleep, and inflammatory responses (Hardeland and Fuhrberg, 1996;Reiter et al., 2000). MT 1 and MT 2 are two well-characterized G protein-coupled plasma membrane melatonin receptors, which are activated by melatonin and regulate multiple cellular and physiological functions, including neuronal activity, arterial vasoconstriction, cell proliferation, immune responses, reproduction, and metabolic functions (Stankov and Reiter, 1990;Dubocovich and Markowska, 2005;Ekmekçioğlu, 2006Ekmekçioğlu, , 2014. In addition, melatonin has high-affinity binding for nuclear receptors ROR/RZR, which operate as transcriptional activators, and it also interacts with other intracellular proteins, like quinone reductase-2 (or MT 3 ) and calmodulin (Reppert et al., 1994;Wiesenberg et al., 1998). For the regulation of gene expression, it has been proposed that ROR/RZR work in cooperation with the plasma membrane receptors MT 1 /MT 2 (Carrillo-Vico et al., 2005). Regarding the regulation of the cellular redox status, melatonin possibly interacts with quinone reductase, even though the detailed role of this interaction remains poorly understood .Melatonin and calmodulin possess low-affinity interaction, which may relate to their antioxidant actions, as well as other signaling processes (Luchetti et al., 2010). Various studies describe melatonin and its derivatives as broad-spectrum antioxidants, related to their ability to Abstract: Melatonin acts classically through the widely expressed G protein-coupled membrane receptors MT 1 and MT 2 , respectively. The functional role of the MT receptors is not fully clear with multiple effects, such as effects on the circadian, reproductive, immune, cardiovascular, and intestinal systems, being suggested. In addition to receptor-mediated effects, melatonin also acts ...

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Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration

Cited by 95 publications

References 40 publications

Effects of Ellagic acid and Hesperetin on Levels of Some Elements in Livers of Aluminum-Induced Rats

Effects of Ellagic acid and Hesperetin on Levels of Some Elements in Livers of Aluminum-Induced Rats

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

Prooxidant effects of melatonin: a brief review

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