Pro-oxidant and anti-oxidant status in patients of sickle cell anaemia

Abstract

The role of oxidant damage to red cells in sickle cell anaemia has been of interest in recent years. Although, available reports suggest that sickle cell erythrocytes are susceptible to endogenous free radical mediated oxidant damage there remains discrepancy in the status of antioxidant enzymes and antioxidant vitamins in these patients. In view of this, 107 cases of sickle cell anaemia (36 'SS' and 71 'AS' pattern-as confirmed by haemoglobin electrophoresis) were subjected to analysis of malondialdehyde, ascorbic acid, superoxide dismutase and albumin. The results were compared with 54 age and sex matched healthy controls. The results indicate a marked increase in lipid peroxidation and superoxide dismutase levels in both 'SS' and 'AS' types of sickle cell anaemia as compared to controls. Although no difference was observed in the levels of albumin in these groups the levels of ascorbic acid were significantly depleted in sickle cell anaemia patients. The results are indicative of enhanced lipid peroxidation along with imbalance in the pro-oxidant and antioxidant status in patients of sickle cell anaemia.

Increased oxidative stress alters nucleosides metabolite levels in sickle cell anemia

“…In our study, the serum levels of TBARS levels was significantly elevated in SCA patients. This is in agreement with previous studies where index of lipid peroxidation was reported to be increased in SCA patients [61][62][63]. RBCs are particularly susceptible to peroxidative damage because they contain hemoglobin, which has one of the powerful catalysts (Fe 2+ ) for initiation of peroxidative reaction [64].…”

Association of Inflammatory Biomarker C-Reactive Protein, Lipid Peroxidation and Antioxidant Capacity Marker with HbF Level in Sickle Cell Disease Patients from Chattisgarh

“…In the present study data showed that there were increases in oxidative stress and inflammatory markers in SCD patients with painful episode (VOC) and in steady state. Some previous studies among sickle cell patients found similar results with steady state [18][19][20], and in sickle cell crises [21][22][23]. No information to the best of our knowledge is available on the level of inflammatory and oxidative stress markers in SCD patients in Chattisgarh.…”

Evaluation of Albumin, Zinc and Vitamin C in Surgical Wound Patients

“…In the same vein, it regulates nitric oxide synthase that generates the nitric oxide, a potent vasodilator that plays a key role in controlling the cardiovascular system. It also decreases the activity of (NADPH) oxidase and (ROS) production, and regulates the antioxidant enzyme including superoxide dismutase and glutathione (Titus et al, 2004). …”

“…Vitamin C is needed for healing wounds, and for repairing and maintaining bones and teeth. It also helps the body absorb iron from nonheme sources (Titus et al, 2004). …”