(Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease

Yoshida, Akihiro; Kanamori, Hiromitsu; Naruse, Genki; Minatoguchi, Shingo; Iwasa, Motoh; Yamada, Yoshihisa; Mikami, Atsushi; Kawasaki, Masanori; Nishigaki, Kazuhiko; Minatoguchi, Shinya

doi:10.1016/j.cardfail.2019.02.009

Cited by 12 publications

(10 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, human peripheral blood mononuclear cells exposed to pharmacological doses of renin produce proinflammatory cytokines IL-6, TNF-α and IFNγ independently from the Ang-II-AT1R pathway [119]. Actually, besides its enzymatic role, PRR triggers macrophage infiltration in glomerulonephritis [132] and chronic kidney disease-associated heart failure [133]. More investigations are needed to explore the role of PRR in monocyte/macrophage recruitment and polarization in DN.…”

Section: Local Components Of the Ras In Monocytes/macrophagesmentioning

confidence: 99%

Regulation of Monocytes/Macrophages by the Renin–Angiotensin System in Diabetic Nephropathy: State of the Art and Results of a Pilot Study

Moratal

Laurain

Naïmi

et al. 2021

IJMS

View full text Add to dashboard Cite

Diabetic nephropathy (DN) is characterized by albuminuria, loss of renal function, renal fibrosis and infiltration of macrophages originating from peripheral monocytes inside kidneys. DN is also associated with intrarenal overactivation of the renin–angiotensin system (RAS), an enzymatic cascade which is expressed and controlled at the cell and/or tissue levels. All members of the RAS are present in the kidneys and most of them are also expressed in monocytes/macrophages. This review focuses on the control of monocyte recruitment and the modulation of macrophage polarization by the RAS in the context of DN. The local RAS favors the adhesion of monocytes on renal endothelial cells and increases the production of monocyte chemotactic protein-1 and of osteopontin in tubular cells, driving monocytes into the kidneys. There, proinflammatory cytokines and the RAS promote the differentiation of macrophages into the M1 proinflammatory phenotype, largely contributing to renal lesions of DN. Finally, resolution of the inflammatory process is associated with a phenotype switch of macrophages into the M2 anti-inflammatory subset, which protects against DN. The pharmacologic interruption of the RAS reduces albuminuria, improves the trajectory of the renal function, decreases macrophage infiltration in the kidneys and promotes the switch of the macrophage phenotype from M1 to M2.

show abstract

Section: Local Components Of the Ras In Monocytes/macrophagesmentioning

confidence: 99%

Regulation of Monocytes/Macrophages by the Renin–Angiotensin System in Diabetic Nephropathy: State of the Art and Results of a Pilot Study

Moratal

Laurain

Naïmi

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…l Cardiac dysfunction and dilatation of the left ventricle was observed 8 weeks after partial nephrectomy l A treatment reversed cardiac dilatation and significantly improved cardiac dysfunction [19] 3.1 Evaluating Kidney Size and Anatomy B-Mode, as introduced in Measurement concepts (2. ), is used to locate the kidneys in the abdomen, observe the surrounding tissue and anatomical structure and to obtain organ size.…”

Section: Assess Cardiac Dimensions and Functionmentioning

confidence: 99%

“…Moving through the whole organ in in both imaging planes in 2D allows to systematically screen for changes inside and also in the surroundings (e.g., ascites in the peritoneum). In addition, ultrasound imaging also may be used to study cardiovascular disease linked to chronic kidney disease [19].…”

Section: Assess Cardiac Dimensions and Functionmentioning

confidence: 99%

Ultrasound and Photoacoustic Imaging of the Kidney: Basic Concepts and Protocols

Meyer

Fuchs

Meier

2021

Methods in Molecular Biology

View full text Add to dashboard Cite

Noninvasive, robust, and reproducible methods to image kidneys are provided by different imaging modalities. A combination of modalities (multimodality) can give better insight into structure and function and to understand the physiology of the kidney. Magnetic resonance imaging can be complemented by a multimodal imaging approach to obtain additional information or include interventional procedures. In the clinic, renal ultrasound has been essential for the diagnosis and management of kidney disease and for the guidance of invasive procedures for a long time. Adapting ultrasound to preclinical requirements and for translational research, the combination with photoacoustic imaging expands the capabilities to obtain anatomical, functional, and molecular information from animal models. This chapter describes the basic concepts of how to image kidneys using different and most appropriate modalities.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

show abstract

“…Kidney disease was associated with high incidence of cardiovascular complications [73]. Nephrectomy causes water and sodium excretion disorders, resulting in increased blood volume, extracellular fluid volume, ventricular pressure, and volume overload; this ultimately leads to cardiac disease.…”

Section: Unilateral Nephrectomy Modelmentioning

confidence: 99%

“…e 5/6 nephrectomy model is considered a classic model for studying cardiovascular complications of kidney disease. Recent studies have shown that cardiac hypertrophy, impaired cardiac function, and increased myocardial fibrosis occurred 8 weeks after nephrectomy in mice [73,76]. In experimental CKD mice, myocardial fibrosis occurred 4 weeks after nephrectomy with lower mortality rate (about 20%) [77].…”

Section: Unilateral Nephrectomy Modelmentioning

confidence: 99%

Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload

Ding

Wang

Jia

et al. 2020

International Journal of Hypertension

View full text Add to dashboard Cite

Myocardial fibrosis is characterized by excessive deposition of myocardial interstitial collagen, abnormal distribution, and excessive proliferation of fibroblasts. According to the researches in recent years, myocardial fibrosis, as the pathological basis of various cardiovascular diseases, has been proven to be a core determinant in ventricular remodeling. Pressure load is one of the causes of myocardial fibrosis. In experimental models of pressure-overload-induced myocardial fibrosis, significant increase in left ventricular parameters such as interventricular septal thickness and left ventricular posterior wall thickness and the decrease of ejection fraction are some of the manifestations of cardiac damage. These morphological and functional changes have a serious impact on the maintenance of physiological functions. Therefore, establishing a suitable myocardial fibrosis model is the basis of its pathogenesis research. This paper will discuss the methods of establishing myocardial fibrosis model and compare the advantages and disadvantages of the models in order to provide a strong basis for establishing a myocardial fibrosis model.

show abstract

(Pro)renin Receptor Blockade Ameliorates Heart Failure Caused by Chronic Kidney Disease

Cited by 12 publications

References 48 publications

Regulation of Monocytes/Macrophages by the Renin–Angiotensin System in Diabetic Nephropathy: State of the Art and Results of a Pilot Study

Regulation of Monocytes/Macrophages by the Renin–Angiotensin System in Diabetic Nephropathy: State of the Art and Results of a Pilot Study

Ultrasound and Photoacoustic Imaging of the Kidney: Basic Concepts and Protocols

Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload

Contact Info

Product

Resources

About