Proanthocyanidin prevents methotrexate-induced intestinal damage and oxidative stress

Güleç, Mustafa; Erdem, Onur; Öztaş, Emin; Kesik, Vural; Balamtekin, Necati; Vurucu, Sebahattin; Kul, Mustafa; Kısmet, Erol; Köseoğlu, Vedat

doi:10.1016/j.etp.2009.02.120

Cited by 44 publications

(44 citation statements)

References 15 publications

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“…It was shown that PAs increased glutathione peroxidase levels and decreased the jejunal damage caused by MTX treatment. 36 A similar result was proven by Yüncü et al in an experimental study performed with the supplementation of vitamin A which had antioxidant properties. 37 In our animal model, the attenuating of villi damaged was noteworthy in the intestinal mucosa after the use of GE.…”

supporting

confidence: 69%

The Effectiveness of Grape Extract in Rats with Methotrexate Induced Intestinal Mucositis

Yılmaz¹,

Dağlıoğlu²,

Bayram³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To investigate histopathologically whether grape extract (Vitis Vinifera L), a potent free radical scavenger and can ameliorate the methotrexate -induced intestinal mucositis. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Wistar albino male rats were assigned to 3 groups: Group 1 (n=7) control group: An equal volume of distilled water that used for grape extract was given throughout the 15 days and physiological saline was administered intraperitoneally on the 10th day. Group 2 (n=10) methotrexate group: Rats received an equal volume of distilled water. A single dose of 20 mg/kg methotrexate was given intraperitoneally on the 10th day. Group 3 (n=10) methotrexate-grape extract group: The same dose of methotrexate was applied intraperitoneally on the 10 th day. For milliliters grape extract solution was administered for 15 consecutive days. Complete blood counts were analyzed from each rat. R Re es su ul lt ts s: : The control group showed normal intestinal structure. Group 2 had villus shortening and fusion with variable degrees of epithelial atrophy (p=0.001). The number of crypt cells was decreased and crypt loss was prominent (p=0.007). Inflammatory infiltration and decreased goblet cell number in both villi and crypts were distinctive (p<0.001). Villous and crypt injury, and inflammatory infiltration was less in group 3. In addition, goblet cells were increased. The difference was significant between group 2 and 3 for the jejunum damage (p=0.021). Hemoglobin levels increased in group 3. C Co on nc cl lu us si io on n: : Present study suggested that grape extract could be useful in the ameliorating intestinal damage caused by methotrexate. Its effect could be attributed to its antioxidant properties. Grape extract may have a clinical application in cancer chemotherapy.K Ke ey y W Wo or rd ds s: : Methotrexate; mucositis; grape seed extract; intestinal diseases Ö ÖZ ZE ET T A Am ma aç ç: : Potansiyel bir serbest radikal yok edici olan üzüm ekstresinin (Vitis Vinifera L) metotreksat ile oluşturulmuş ince bağırsak mukozitini histopatolojik olarak iyileştirip iyileştirmediğini araştırmak. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Wistar albino erkek sıçanlar 3 gruba ayrıldı. Grup 1 (n=7) kontrol grup: Üzüm ekstresi ile aynı miktarda olan distile su 15 gün boyunca kullanıldı ve 10. günde serum fizyolojik intraperitoneal olarak verildi. Grup 2 (n=10) metotreksat grubu: Sıçanlar aynı miktar distile su aldılar. Tek doz 20 mg/kg metotreksat 10. günde verildi. Grup 3 (n=10) Metotreksatüzüm ekstresi grubu: Aynı doz metotreksat 10. günde intraperitoneal olarak uygulandı. Dört mililitre üzüm ekstresi solüsyonu 15 gün boyunca alındı. Tam kan sayımı her bir sıçandan analiz edildi. B Bu ul lg gu ul la ar r: : Kontrol grup normal ince bağırsak yapısını gösterdi. Grup 2 değişik derecelerde epitel atrofisi ile birlikte villüs kısalması ve füzyonuna sahipti (p=0.001). Kript hücrelerinin sayısı azalmış ve kript kaybı belirgindi (p=0.007). Hem villüs...

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supporting

confidence: 69%

The Effectiveness of Grape Extract in Rats with Methotrexate Induced Intestinal Mucositis

Yılmaz¹,

Dağlıoğlu²,

Bayram³

et al. 2012

Turkiye Klinikleri J Med Sci

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“…Our results were parallel to some studies which indicated, the after MTX intoxication, significant depletion of the GSH level and also significant decreases in activities of SOD, CAT and GPx was evidenced, corroborating the state of oxidative stress. 23,32,33 MDA is one of the most commonly markers of lipid peroxidation. Lipid peroxidation is a wellknown mechanism of cellular injury in the human body.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effects of Hydroalcoholic Extract of Lavandula officinalis L. on Methotrexate-Induced Oxidative Stress in Rats

Kalantar¹,

Shirali²,

Hasanvand³

et al. 2017

Pharm Sci

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“…Proanthocyanidins are believed to be the key bioactive constituents in GSE (47). Administration of proanthocyanidin decreased the jejunal damage and malondialdehyde level, which were caused by MTX treatment and increased superoxide dismutase and glutathione peroxidase levels in rats (48,49).…”

Section: Probioticsmentioning

confidence: 99%

A review of complementary therapies for chemotherapy induced gastrointestinal mucositis

Kuchay

2016

DD&T

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Proanthocyanidin prevents methotrexate-induced intestinal damage and oxidative stress

Cited by 44 publications

References 15 publications

The Effectiveness of Grape Extract in Rats with Methotrexate Induced Intestinal Mucositis

The Effectiveness of Grape Extract in Rats with Methotrexate Induced Intestinal Mucositis

Ameliorative Effects of Hydroalcoholic Extract of Lavandula officinalis L. on Methotrexate-Induced Oxidative Stress in Rats

A review of complementary therapies for chemotherapy induced gastrointestinal mucositis

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