Proanthocyanidins from Barley Bran Potentiate Retinoic Acid-induced Granulocytic and Sodium Butyrate-induced Monocytic Differentiation of HL60 Cells

Determination of γ-Aminobutyric Acid and Free Amino Acid Contents in Barley Seeds and Amounts Produced by Water Soaking Treatment

“…Deguchi et al (1999) focused on purple pigment, hordeumin, from barley branfermented broth and reported its antimutagenicity (Deguchi et al, 2000a) and radical scavenging activity (Deguchi et al, 2000b). Barley proanthocyanidins, abundant in bran, have been reported to potentiate retinoic acid-induced granulocytic and sodium butyrate-induced monocytic differentiation of HL60 cells (Tamagawa et al, 1998), and have inhibitory effects on hyaluronidase activity, soybean lipoxygenase activity, and complementary activity (Tamagawa et al, 1999). γ-Aminobutyric acid (GABA) is a non-protein amino acid and serves as a major transmitter inhibitor in mammalian systems (Nathan et al, 1994).…”

Proliferation and Differentiation of Hematopoietic Cells and Preservation of Immune Functions

“…In addition to that, Phyco-CM increased also the NBT reducing activity of HL-60 cells. Tamagawa et al (1998) reported that NBT reducing activity was used as a marker of HL-60 cell differentiation into granulocytes and monocytes. Fontana et al (1981) suggested that HL-60 cells were able to commit themselves to the development of two different program of hematopoietic differentiation, that is, either myeloid or macrophage depending on cytokine or stimulant.…”

Tannins and Tannin Agents

“…In the review of Chung et al (1998), the authors indicate that the incidences of certain cancers have been related to consumption of tannin-rich foods, while other reports indicate that carcinogenic activity might rather be related to components associated with tannins. Vice versa, CTs have also been shown to prevent the growth of human cancer cells in vitro (Tamagawa and Fukushima, 1998;Ye and Krohn, 1999). In addition, the health-promoting role of tannins has been increasingly studied and it has been shown that tannins are able to reduce the levels of serum lipids and blood pressure as well as to improve brain health (Jerez et al, 2007).…”