Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis

Wang, Yanhong; Ge, Bin; Yang, Xiaolai; Zhai, Jing; Yang, Lining; Wang, Xiaoxia; Liu, Xia; Jin-cheng, Shi; Wu, Yongjie

doi:10.1016/j.intimp.2011.05.024

Cited by 95 publications

(65 citation statements)

References 37 publications

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“…In resting stage, NF-kB normally localizes to the cytoplasm, where it is bound by IkB proteins. During inflammatory stimulus, IkB is phosphorylated by IkB kinase, subsequently degraded by proteasome, then get released and translocates into the nucleus, where it triggers the transcription of multiple genes involved in inflammatory cascade (Wang et al, 2011). The present study confirms that B. sensitivum could inhibit the activation and nuclear translocation of NF-kB subunits p50 and p65.…”

Section: Discussionsupporting

confidence: 81%

Modulating effect ofBiophytum sensitivumextract on rats with acetic acid-induced ulcerative colitis

Sakthivel

Guruvayoorappan

2014

Pharmaceutical Biology

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Context: Traditionally, Biophytum sensitivum (L.) DC (Oxalidaceae) is used in Indian medicine to treat diseases include stomachache, convulsions, cramps, inflammation, and ulcer. Objective: The present study examines the effect of aerial parts of B. sensitivum (methanol extract) on a murine model of ulcerative colitis (UC). Materials and methods: UC was induced by intracolonic injection of 3% acetic acid in Wistar rats. B. sensitivum (50 or 100 mg/kg b wt) or reference drug sulfasalazine (100 mg/kg b wt) was administrated intra-peritoneally for 5 consecutive days before induction of colitis. Results: In the present study, we demonstrated for the first time that the administration of B. sensitivum (50 mg/kg b wt) was found to inhibit colitis by lowering macroscopic score (up to 3.66 ± 0.77) and also showed significant reduction (p50.01) in lactate dehydrogenase (LDH) and myeloperoxidase (MPO) activities. Furthermore, a significant reduction (p50.01) in mucosal content of lipid peroxidation (LPO), glutathione (GSH), superoxide dismutase (SOD), and nitric oxide (NO) confirms that B. sensitivum could significantly inhibit colitis. The study showed significant reduction (p50.01) in colonic tumor necrosis factor-a (TNF-a), interleukin-1-b (IL-1b), and IL-6 levels as well as the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) after treatment compared with the colitis control group. The histopathological study also confirms the foregoing findings. Treatment with B. sensitivum was also able to inhibit the activation and translocation of transcription factors, nuclear factor (NF)-kB subunits (p65/p50). Conclusion: These results suggest that B. sensitivum exhibits protective effect against acetic acid-induced UC.

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Section: Discussionsupporting

confidence: 81%

Modulating effect ofBiophytum sensitivumextract on rats with acetic acid-induced ulcerative colitis

Sakthivel

Guruvayoorappan

2014

Pharmaceutical Biology

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“…Enzymatic antioxidants such as the GSH-Px, the SOD and the CAT constitute the antioxidant system and these defense systems protect the cells against oxidative stress. Using an antioxidant agent, Xing et al and Wang et al observed a higher the GSH-Px levels in the treatment groups compared to TNBS groups in their TNBS colitis studies [32,33]. In our study, the GSH-Px level was also higher in the RSV treated group compared to TNBS and TNBS+DMSO groups (p < 0.05).…”

Section: Discussionsupporting

confidence: 65%

“…Then, the CAT and the GSHPx enzymes try to convert hydrogen peroxide to water to prevent the ROS injury in the cell. In the literature, a number of studies have shown a higher activity for the SOD and the CAT enzymes in TNBS colitis in rats [32][33][34][35]. On the contrary, Beno et al found the lower activities for the SOD and the CAT enzymes in colonic mucosa of 17 patients with idiopathic proctocolitis after 5-aminosalicylic acid treatment compared to activities of the same enzymes before the treatment [36].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats

Yıldız¹,

Yildiz²,

Ulutaş³

et al. 2015

EMI

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Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disease in humans constituting a major health concern today whose prevalence has been increasing over the world. Production of reactive oxygen species (ROS) and disturbed capacity of antioxidant defense in IBD subjects have been reported. Antioxidants may play a significant role in IBD treatment. This study aimed at evaluating ameliorative effects of intraperitoneal resveratrol pretreatment on trinitrobenzene sulphonic acid (TNBS)-induced colitis in rats. Thirty five Wistar-Albino female rats were divided equally into five groups. Inflammation was induced by the intrarectal administration of TNBS under anesthesia. Intraperitoneal administration of resveratrol (RSV) at a concentration of 10mg/kg/day for 5 days before the induction of colitis significantly reduced microscopy score and malondialdehyde (MDA) levels and increased glutathione peroxidase (GSH Px) activity compared to TNBS and vehicle groups. Also an insignificant increase in catalase (CAT) activity was observed in the RSV treated group compared to TNBS and vehicle groups. In this paper, the most recent patent on the identification and treatment of IBD was indicated. In conclusion, antioxidant RSV proved to have a beneficial effect on TNBS colitis in rats. In light of these advantageous results, the RSV can be considered as adjuvant agent in IBD treatments.

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“…Furthermore, both luteolinidin and apigeninidin in sorghum belong to phytoalexin due to their responsibilities of anti-fungal invasion and/or anti-stressful activities [13,25]. Dietary sorghum 3-deoxyanthocyanidins have been also associated with human health benefits such as prevention of obesity and diabetes through antioxidant and anti-inflammatory mechanisms [26].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic Diversity of Anthocyanins in Sorghum Accessions with Various Pericarp Pigments

Su¹,

Rhodes²,

Xu³

et al. 2017

J Nutr Food Sci

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Anthocyanins, a sub-class of flavonoids, are natural pigments known to have functional health benefits. Sorghum is a rich source of various phytochemicals including anthocyanins. This study was to identify and quantify the profiles of anthocyanins by HPLC-DAD in the selected 25 sorghum accessions with various phenotypic pericarp pigments. The predominant anthocyanins found in sorghums were 3-deoxyanthocyanidins including the unique leuteolinidin and apigeninidin analogs. The high levels of total anthocyanins were found in the red pericarp PI297139 and the brown pericarp PI221723, followed by the brown pericarp PI35038 and the yellow pericarp PI229838. There were moderate to low levels of anthocyanins observed in all the other accessions except for the white pericarp that generally contained least to undetectable amount. Although anthocyanins appeared to be associated with the pericarp color in the sorghum accessions with the highest contents in each pericarp pigment category, a distinguishable diversity of anthocyanin contents was presented among and between the phenotypic pericarp colors, suggesting other colorful phytochemicals such as carotenoids might be contributed. Establishing a database of anthocyanin profile and diversity in sorghum accessions with various pericarp pigments may lead to the development of novel functional sorghum products with active anthocyanin-enriched health benefits.

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Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis

Cited by 95 publications

References 37 publications

Modulating effect ofBiophytum sensitivumextract on rats with acetic acid-induced ulcerative colitis

Modulating effect ofBiophytum sensitivumextract on rats with acetic acid-induced ulcerative colitis

Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats

Phenotypic Diversity of Anthocyanins in Sorghum Accessions with Various Pericarp Pigments

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